Tetrazine-PEG4-amine hydrochloride functions as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) functionalized molecules. It is essential for the development of targeted therapies, facilitating the selective delivery of cytotoxic agents to cancer cells while minimizing off-target effects.
Tetrazine-PEG4-amine hydrochloride functions as a cleavable linker in the synthesis of antibody-drug conjugates (ADCs). This compound features a tetrazine group, enabling it to participate in inverse electron demand Diels-Alder (iEDDA) reactions with trans-cyclooctene (TCO) functionalized molecules. It is essential for the development of targeted therapies, facilitating the selective delivery of cytotoxic agents to cancer cells while minimizing off-target effects.
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