Tetromycin B is a potent cysteine protease inhibitor, demonstrating Ki values of 0.62, 1.42, 32.5, and 1.59 μM against rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. This compound effectively inhibits the growth of Trypanosoma brucei in vitro with an IC50 of 30.87 μM. Additionally, Tetromycin B exhibits cytotoxic effects on HEK293T kidney cells and J774.1 macrophages, with IC50 values of 71.77 μM and 20.2 μM, respectively, highlighting its potential utility in research applications targeting parasitic infections.
Tetromycin B is a potent cysteine protease inhibitor, demonstrating Ki values of 0.62, 1.42, 32.5, and 1.59 μM against rhodesain, falcipain-2, cathepsin L, and cathepsin B, respectively. This compound effectively inhibits the growth of Trypanosoma brucei in vitro with an IC50 of 30.87 μM. Additionally, Tetromycin B exhibits cytotoxic effects on HEK293T kidney cells and J774.1 macrophages, with IC50 values of 71.77 μM and 20.2 μM, respectively, highlighting its potential utility in research applications targeting parasitic infections.
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