TJN-331 is a potent, orally active inhibitor of TGF-β1, targeting the TGF-β signaling pathway. This compound demonstrates significant therapeutic potential by ameliorating anti-glomerular basement membrane nephritis in rat models, reducing extracapillary proliferation in glomeruli. Additionally, TJN-331 inhibits mesangial expansion in experimental IgA nephropathy in ddY mice, making it a valuable tool for researching nephritis and IgA nephropathy.
TJN-331 is a potent, orally active inhibitor of TGF-β1, targeting the TGF-β signaling pathway. This compound demonstrates significant therapeutic potential by ameliorating anti-glomerular basement membrane nephritis in rat models, reducing extracapillary proliferation in glomeruli. Additionally, TJN-331 inhibits mesangial expansion in experimental IgA nephropathy in ddY mice, making it a valuable tool for researching nephritis and IgA nephropathy.
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