Catalog No.: A17252

JAK3/2/1 inhibitor


Tofacitinib Chemical Structure

CAS NO. 477600-75-2

Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.

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50 mg

Regular Price: $81.00

Special Price $64.80

100 mg

Regular Price: $140.00

Special Price $112.00

500 mg

Regular Price: $414.00

Special Price $331.20

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Biological Activity

Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively.
In vitro (25°C) DMSO Warmed: 56 mg/mL (179.27 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.01 mL 160.07 mL 320.13 mL
0.5 mM 6.4 mL 32.01 mL 64.03 mL
1 mM 3.2 mL 16.01 mL 32.01 mL
5 mM 0.64 mL 3.2 mL 6.4 mL

*The above data is based on the productmolecular weight 312.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A17252
Actions Inhibitor
CAS No. 477600-75-2
Formula C16H20N6O
M. Wt 312.37
Purity >98%
Synonyms Tasocitinib; CP-690550
SMILES O=C(CC#N)N1C[[email protected]](N(C2=C3C(NC=C3)=NC=N2)C)[[email protected]](C)CC1

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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