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CP-690550 (Tofacitinib citrate)

Catalog No.: A10241

JAK3 inhibitor

CP-690550 (Tofacitinib citrate)

CP-690550 (Tofacitinib citrate) Chemical Structure

CAS NO. 540737-29-9

CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.

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10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
Target Value
JAK3IC50: 1nM
JAK2IC50: 20nM
JAK1IC50: 112nM
ROCK2IC50: 3.4μM
LCKIC50: 3.87μM
IRKIC50: >10μM
CDK2IC50: >10μM
CDK5IC50: >10μM
EGFRIC50: >10μM
MAPK2/ERK2IC50: >10μM
JNK1/SAPK1cIC50: >10μM
SAPK2a/p38IC50: >10μM
SAPK2b/p38b2IC50: >10μM
SAPK3/p38gIC50: >10μM
SAPK4/p38dIC50: >10μM
MAPKAP-K1bIC50: >10μM
MSK1IC50: >10μM
PRAKIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
PDK-1IC50: >10μM
PKBαIC50: >10μM
SGKIC50: >10μM
p70S6KIC50: >10μM
GSK-3βIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK2IC50: >10μM
PHKIC50: >10μM
CSKIC50: >10μM
CDK2/CyclinAIC50: >10μM
PI3KIC50: >10μM
In vitro (25°C) DMSO Warmed: 94 mg/mL (186.32 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% methylcellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.11 mL 198.22 mL
0.5 mM 3.96 mL 19.82 mL 39.64 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10241
Actions Inhibitor
CAS No. 540737-29-9
Formula C16H20N6O.C6H8O7
M. Wt 504.5
Purity >98%
Synonyms CP690550, tasocitinib citrate, CP-690,550
SMILES C[[email protected]@H]1CCN(C[[email protected]@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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