CP-690550 (Tofacitinib citrate)

Catalog No.: A10241

JAK3 inhibitor

CP-690550 (Tofacitinib citrate)

CP-690550 (Tofacitinib citrate) Chemical Structure

CAS NO. 540737-29-9

CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $60.00

Special Price $48.00

50 mg

Regular Price: $220.00

Special Price $176.00

100 mg

Regular Price: $380.00

Special Price $304.00

10mM * 1mL in DMSO
$89.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

CP-690550 (Tofacitinib citrate) is an orally available, highly selective inhibitor of the Janus kinase (JAK) family of enzymes.
Targets
Target Value
JAK3IC50: 1nM
JAK2IC50: 20nM
JAK1IC50: 112nM
ROCK2IC50: 3.4μM
LCKIC50: 3.87μM
IRKIC50: >10μM
CDK2IC50: >10μM
CDK5IC50: >10μM
EGFRIC50: >10μM
MAPK2/ERK2IC50: >10μM
JNK1/SAPK1cIC50: >10μM
SAPK2a/p38IC50: >10μM
SAPK2b/p38b2IC50: >10μM
SAPK3/p38gIC50: >10μM
SAPK4/p38dIC50: >10μM
MAPKAPK2IC50: >10μM
MAPKAP-K1bIC50: >10μM
MSK1IC50: >10μM
PRAKIC50: >10μM
PKAIC50: >10μM
PKCαIC50: >10μM
PDK-1IC50: >10μM
PKBαIC50: >10μM
SGKIC50: >10μM
p70S6KIC50: >10μM
GSK-3βIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK2IC50: >10μM
PHKIC50: >10μM
CSKIC50: >10μM
CDK2/CyclinAIC50: >10μM
PI3KIC50: >10μM
In vitro (25°C) DMSO 100 mg/mL (198.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% methylcellulose 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.82 mL 99.11 mL 198.22 mL
0.5 mM 3.96 mL 19.82 mL 39.64 mL
1 mM 1.98 mL 9.91 mL 19.82 mL
5 mM 0.4 mL 1.98 mL 3.96 mL

*The above data is based on the productmolecular weight 504.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10241
Actions Inhibitor
M. Wt 504.5
Formula C16H20N6O.C6H8O7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 540737-29-9
Synonyms CP690550, tasocitinib citrate, CP-690,550
SMILES C[[email protected]@H]1CCN(C[[email protected]@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

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