Tralopyril is a potent ferroptosis inducer that selectively targets the thyroid hormone system and mitochondrial oxidative phosphorylation pathways. It promotes ferroptosis by downregulating key transcription factors such as TRHR, Nkx2.1, and TRα, thereby disrupting amino acid, energy, and lipid metabolism. Despite its primary application as an antifouling insecticide, its significant toxicity to skeletal and reproductive systems, alongside its implications for developmental damage, renders it useful in toxicological studies. Tralopyril's long half-life in vivo and broad tissue distribution highlight potential risks to both aquatic organisms and human health.
Tralopyril is a potent ferroptosis inducer that selectively targets the thyroid hormone system and mitochondrial oxidative phosphorylation pathways. It promotes ferroptosis by downregulating key transcription factors such as TRHR, Nkx2.1, and TRα, thereby disrupting amino acid, energy, and lipid metabolism. Despite its primary application as an antifouling insecticide, its significant toxicity to skeletal and reproductive systems, alongside its implications for developmental damage, renders it useful in toxicological studies. Tralopyril's long half-life in vivo and broad tissue distribution highlight potential risks to both aquatic organisms and human health.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
