Catalog No.
Product Name
Application
Product Information
Citations
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K+ Channel Blocker
Dendrotoxin-I (DTX-I) is a potent inhibitor of voltage-gated potassium channels, specifically targeting the KV1.1, KV1.2, and KV1.6 subunits with IC50 values ranging from 0.13 to 50 nM. This neurotoxin exhibits significant biological activity that can influence neuronal excitability and synaptic transmission. Dendrotoxin-I is primarily utilized in research applications related to cancer and neurobiology, providing insights into ion channel function and their roles in disease mechanisms. -
Antitumor Agent
Chlorotoxin is a 36 amino acid peptide derived from the venom of the Israeli scorpion, Leiurus quinquestriatus, known for its antitumor properties. By functioning as a chloride channel blocker, Chlorotoxin inhibits the proliferation of cancer cells and modulates ion channel activity. This compound is valuable for cancer research, particularly in studies investigating tumor biology and the development of targeted therapies. -
Na+ Channel Activator
Brevetoxin-3 (PbTx-3) is a potent allosteric activator of voltage-gated Na+ channels. It demonstrates high affinity for site 5 on these channels, effectively inhibiting their inactivation and prolonging the mean open time. This compound is valuable for research into airway hyperresponsiveness and lung inflammation, as repeated exposure has been shown to induce these conditions. Brevetoxin-3 serves as a critical tool for studying sodium channel modulation and its implications in respiratory pathophysiology. -
SERCA Inhibitor
2,5-Di-tert-butylhydroquinone is a potent inhibitor of Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), demonstrating an IC50 of 400 nM. This compound disrupts the gating function of Glu309, thereby preventing calcium ions from accessing their binding site. Additionally, 2,5-Di-tert-butylhydroquinone influences the activity of key enzymes such as 5-lipoxygenase and COX-2, with IC50 values of 1.8 μM and 14.1 μM, respectively. It is utilized in research focused on cellular calcium regulation and inflammatory processes. -
Calcium Channel Antagonist
Ginsenoside Ro functions as a calcium channel antagonist, exhibiting an effective antiplatelet activity with an IC50 of 155 µM. This compound notably reduces the production of thromboxane A2 (TXA2) while minimally affecting the activities of cyclooxygenase-1 (COX-1) and thromboxane synthase (TXAS). Ginsenoside Ro is valuable in research related to cardiovascular diseases and platelet aggregation studies. -
Calcium Channels Antagonist
L-Phenylalanine, a competitive antagonist of the α2δ subunit of voltage-dependent calcium channels, exhibits a Ki of 980 nM. It also interacts with glycine- and glutamate-binding sites on N-methyl-D-aspartate receptors (NMDARs), with a KB value of 573 μM. This essential amino acid plays a significant role in various biological processes and is frequently utilized in research concerning neuropharmacology and receptor interactions, as well as in the synthesis of food flavors and pharmaceuticals. -
hERG Channel Blocker
Tannic acid is identified as a novel hERG channel blocker, exhibiting an IC50 of 3.4 μM. This compound has significant implications in cardiovascular research, particularly in studying drug-induced long QT syndrome and cardiac arrhythmias. Its capacity to modulate ion channel activity makes it a valuable tool in pharmacological studies focused on cardiac safety and ion channel function. -
Sodium Channel Activator
3-Deoxyaconitine is a diterpenoid alkaloid identified as a sodium channel activator. It exhibits significant biological activity by modulating ion channel dynamics, making it a valuable tool for research into neuronal signaling and pain pathways. This compound can be utilized in studies focusing on the physiological and pharmacological roles of sodium channels. -
Calcium Channel Activator
Gomisin J is a lignan derived from Schisandra chinensis that primarily acts as a calcium channel activator. It enhances nitric oxide bioavailability through eNOS activation and regulates lipid metabolism via the AMPK pathway. Additionally, Gomisin J exhibits anti-inflammatory effects by inhibiting fetuin-A and NF-κB, while its activation of Nrf2/HO-1 boosts antioxidant capacity. This compound is relevant for studies focused on hypertension, non-alcoholic fatty liver disease, and cerebral ischemia-reperfusion injury. -
Calcium Channel Antagonist
Praeruptorin E serves as a calcium channel antagonist and is the primary bioactive constituent derived from Peucedanum praeruptorum, commonly known as Bai-Hua Qian Hu. This compound exhibits a pD2′ value of 5.2, indicating its efficacy in inhibiting calcium influx in target cells. Its biological activity makes it a valuable tool for research applications exploring calcium signaling pathways and related physiological processes. -
Bacterial Inhibitor
Methyl Paraben is a bacterial inhibitor primarily used as a preservative in various applications due to its stability and non-volatility. It has been shown to enhance histamine release and modulate cellular immune responses, in addition to blocking sodium channels. Its properties make it valuable for studies exploring microbial inhibition and the mechanisms of ischemia-reperfusion injury. -
Antimicrobial Agent
Danofloxacin mesylate is a fluoroquinolone antimicrobial agent that exerts its bactericidal activity primarily through the inhibition of bacterial DNA gyrase, a crucial enzyme for DNA replication. This compound displays a broad spectrum of effectiveness against various bacterial strains. Additionally, Danofloxacin mesylate is recognized as a substrate for ATP-dependent efflux transporters, including P-glycoprotein (P-gp) and multidrug resistance protein 2 (MRP2), making it relevant for studies on drug resistance mechanisms in bacteria. This agent is primarily utilized in veterinary medicine and research on antibiotic efficacy and resistance. -
TASK-1 Inhibitor
Doxapram hydrochloride hydrate is a TASK-1 inhibitor that enhances respiratory function by stimulating the brain's respiratory centers and peripheral chemoreceptors. This compound effectively increases both the rate and depth of breathing, while demonstrating inhibitory effects on TASK-1, TASK-3, and their heterodimeric channels with EC50 values of 410 nM, 37 μM, and 9 μM, respectively. Additionally, it inhibits Ca²⁺-activated and Ca²⁺-independent potassium currents in type I cells of the carotid body, with IC50 values of approximately 13 μM and 20 μM, respectively. Doxapram hydrochloride hydrate serves as a useful reagent for research on respiratory depression conditions, including post-anesthesia recovery, chronic obstructive pulmonary disease, and apnea of prematurity. -
Calcium Channel Inhibitor
Ethosuximide is a calcium channel inhibitor primarily targeting T-type calcium channels, specifically blocking low voltage-activated currents. This compound is extensively used in research for its anti-epileptic properties as well as its potential therapeutic effects in various neurodegenerative disease models. Ethosuximide facilitates the study of calcium signaling pathways and their involvement in neuronal excitability and degeneration. -
Dopamine Receptor Inhibitor
Fluphenazine dihydrochloride is a potent dopamine receptor antagonist primarily targeting dopamine D2 receptors in the mesolimbic, nigrostriatal, and tuberoinfundibular pathways. This phenothiazine derivative also exhibits the ability to inhibit neuronal voltage-gated sodium channels. Its key biological activities include the suppression of Methylphenidate-induced stereotyped behaviors and climbing in murine models. Fluphenazine dihydrochloride is widely utilized in research related to psychosis, diabetic peripheral neuropathy, and may also have implications for the inhibition of SARS-CoV-2. -
Sodium Channel Inhibitor
Oxybuprocaine hydrochloride is a sodium channel inhibitor that reversibly blocks sodium channels, effectively preventing the propagation of painful nerve impulses in tissues such as the cornea, conjunctiva, and sclera. This compound is primarily utilized in ophthalmology and otolaryngology for its anesthetic properties, providing localized pain relief during various medical procedures. Its ability to inhibit nerve signal transmission makes it valuable for both diagnostic and therapeutic applications in ocular and ear, nose, and throat treatments. -
Sodium Channel Inhibitor
Propafenone hydrochloride is a sodium channel inhibitor primarily used as an anti-arrhythmic agent. It effectively treats conditions related to rapid heartbeats, including atrial and ventricular arrhythmias. This compound is useful in research applications focused on cardiac rhythm disturbances and the pharmacological modulation of ion channels. -
Sodium Channel Inhibitor
Triamterene is a sodium channel inhibitor that selectively blocks epithelial Na+ channels (ENaC) in a voltage-dependent manner. It exhibits mild diuretic properties and is utilized in the management of conditions related to fluid retention. Additionally, Triamterene serves as an inhibitor of the TGR5 receptor, contributing to its diverse biological effects and applications in research related to renal and metabolic processes. -
TRP Channel Agonist
Camphor ((±)-Camphor) is recognized as a TRP channel agonist, primarily targeting TRPV3. This compound exhibits notable antiviral, antitussive, and anticancer activities, making it valuable for various research applications. Although utilized topically for its anti-infective and anti-pruritic properties, caution is advised as camphor can be toxic when ingested. Its diverse biological activities make it a significant candidate for studies related to TRPV channel modulation. -
Repellent Agent
Vanillyl butyl ether serves as a repellent agent primarily through its modulation of TRPV1 and TRPM8 channels in mammalian systems. This compound exhibits notable activity against pests such as Tribolium castaneum, T. confusum, and L. bostrychophila, demonstrating its potential in pest control applications. Additionally, it acts as a mild warming agent, promoting enhanced blood circulation while retaining its eco-friendly and non-toxic profile. -
Antiarrhythmic Agent
Mexiletine hydrochloride is an orally active antiarrhythmic agent that primarily functions by inhibiting sodium channels, with an IC50 value of 75±8 μM for tonic block and 23.6±2.8 μM for use-dependent block. This compound has demonstrated efficacy in the management of myotonia and neuropathic pain, making it a valuable tool in both cardiovascular and neurological research. Its ability to modulate ion channel activity allows for insights into the mechanisms of arrhythmias and other related disorders. -
Antiarrhythmic Agent
Disopyramide phosphate is a class IA antiarrhythmic agent that primarily targets cardiac sodium channels, effectively blocking the fast inward sodium current. This compound prolongs cardiac action potentials, making it suitable for the treatment of both ventricular and atrial arrhythmias. In addition, disopyramide phosphate inhibits HERG-encoded potassium channels and exhibits significant negative inotropic effects, contributing to its complex pharmacological profile in heart rhythm management. Its diverse biological activities make it valuable for research in electrophysiology and cardiac pharmacology. -
Voltage-operated Sodium Channels Blocker
Mebeverine hydrochloride is a musculotropic agent acting primarily as a voltage-operated sodium channels blocker. It effectively inhibits intestinal peristalsis and reduces intracellular calcium accumulation, making it valuable for research on gastrointestinal motility disorders. Its ability to modulate sodium channels also supports studies related to excitability in smooth muscle tissues. -
Sodium Channel Inhibitor
Ropivacaine mesylate acts primarily as a sodium channel inhibitor, serving as a long-acting amide local anesthetic. It effectively blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers, making it suitable for procedures requiring spinal block anesthesia. Additionally, Ropivacaine has been identified as an inhibitor of the K2P potassium channel TREK-1, exhibiting an IC50 value of 402.7 μM in COS-7 cell membranes. This compound is relevant for research into pain management and neuronal activity modulation. -
Sodium Channel Blocker
Ajmaline is a sodium channel blocker and a class 1A anti-arrhythmic agent. It effectively inhibits HERG currents with an IC50 of 1 μM in HEK293 cells and 42.3 μM in Xenopus oocytes. This compound is utilized in research focused on ventricular tachyarrhythmia and other cardiac rhythm disorders, contributing to a better understanding of arrhythmic conditions. -
Sodium Channel Inhibitor
Mepivacaine is an amide-type local anesthetic that functions as a sodium channel inhibitor. By binding to specific voltage-gated sodium ion channels in neuronal cell membranes, Mepivacaine effectively inhibits sodium influx and membrane depolarization. This agent is primarily utilized in various research applications within the fields of pain management and anesthesia. -
Potassium Channel Inhibitor
Cloperastine hydrochloride is a potassium channel inhibitor primarily targeting hERG K+ currents. It demonstrates concentration-dependent inhibition, with an IC50 value of 27 nM. This reagent is employed in research applications focused on cardiac ion channel function and drug interactions, providing valuable insights into cardiovascular safety and pharmacology. -
Proton Pump Inhibitor
Ilaprazole sodium is a potent proton pump inhibitor that irreversibly targets H+/K+-ATPase, demonstrating a dose-dependent inhibition with an IC50 of 6 μM in rabbit parietal cell assays. This compound is primarily utilized in research focused on gastric ulcers, providing insights into gastric acid secretion regulation. Additionally, Ilaprazole sodium acts as an effective inhibitor of TOPK (T-lymphokine-activated killer cell-originated protein kinase), facilitating studies related to immune responses and cancer therapeutics. -
Antitussive Agent
Benzonatate (PEGn) is a non-narcotic antitussive agent that exerts its effects primarily through sodium channel blockade and local anesthetic activity on respiratory stretch receptors. It is commonly utilized in research involving cough reflex modulation and respiratory control mechanisms. This compound is valuable for studies aimed at understanding cough pathology and developing cough suppression therapies. -
VMAT2 Inhibitor
Valbenazine tosylate is a selective inhibitor of the vesicular monoamine transporter 2 (VMAT2), exhibiting a Ki value in the range of 110-190 nM. It is primarily employed in research related to neuropharmacology and the treatment of movement disorders, such as tardive dyskinesia. By inhibiting VMAT2, Valbenazine tosylate modulates neurotransmitter release, making it a valuable tool for studying dopaminergic signaling and associated pathologies. -
Calcium Channel Antagonist
Bepridil hydrochloride hydrate is a non-selective, long-acting calcium channel antagonist that also inhibits sodium and potassium channels. It exhibits antianginal properties and functions as a type I antiarrhythmic agent. Additionally, Bepridil hydrochloride hydrate inhibits the cardiac sodium-calcium exchanger (NCX1), making it valuable for research into cardiovascular disorders. -
Sodium Channel Inhibitor
Riluzole hydrochloride is a sodium channel inhibitor that exhibits anticonvulsant properties. It functions primarily as a use-dependent Na+ channel blocker and also has the capability to inhibit GABA uptake, with an IC50 of 43 μM. This compound is commonly utilized in neurological research applications, particularly in studies focused on epilepsy and neuroprotection. -
Calcium Channel Blocker
Amlodipine maleate is a dihydropyridine calcium channel blocker that primarily targets voltage-dependent L-type calcium channels. By inhibiting calcium influx, it serves as an effective antianginal agent and contributes to the management of hypertension. Amlodipine maleate is utilized in research applications related to cardiovascular health, hypertension, and potential anticancer effects. -
Sodium Channel Inhibitor
Ropivacaine hydrochloride is a potent sodium channel inhibitor that effectively disrupts impulse conduction by reversibly blocking sodium ion influx in nerve fibers. Additionally, it inhibits the K2P TREK-1 potassium channel with an IC50 of 402.7 μM in COS-7 cell membranes. This compound is primarily applied in the management of neuropathic pain in various in vivo research contexts. -
ENaC Blocker
Benzamil hydrochloride is a selective blocker of the epithelial sodium channel (ENaC) and serves as an inhibitor of the Na+/Ca2+ exchanger (NCX) with an IC50 of approximately 100 nM. This compound also enhances myogenic vasoconstriction and inhibits TRPP3-mediated Ca2+-activated currents at an IC50 of 1.1 μM. Benzamil hydrochloride is employed in various research applications aimed at studying ion channel regulation and cardiovascular physiology. -
Potassium Channel Inhibitor
Cloperastine fendizoate is a potent inhibitor of the hERG potassium channels, exhibiting concentration-dependent inhibition with an IC50 value of 27 nM. This compound is primarily utilized in research applications focusing on cardiac ion channel function and related arrhythmia studies. Its effects on potassium currents make it valuable for investigating the electrophysiological properties of cardiac tissues and potential therapeutic interventions. -
Sodium Channel Inhibitor
Propoxycaine hydrochloride is a sodium channel inhibitor that disrupts voltage-gated sodium channel activity, leading to a reduction in ionic flux essential for the initiation and propagation of action potentials. This compound is primarily utilized in research to investigate sensory nerve function and analgesic mechanisms, resulting in local anesthetic effects characterized by a loss of sensation. -
Potassium Channel Inhibitor
Tetraethylammonium chloride is a non-selective inhibitor of potassium channels, effectively blocking their function. This compound is recognized as a substrate for organic cation transporter 1 (OCTN1), which may be relevant in transport-related studies. Additionally, tetraethylammonium chloride exhibits potential antitumor properties, making it a valuable tool in cancer research and investigations into ion channel dynamics. -
Antiestrogen
Triphenylethylene is an antiestrogen agent that primarily functions by inhibiting L-type Ca2+ channels. This compound displays weak estrogenic activity and has been shown to relax duodenal intestinal muscle. Triphenylethylene is useful in research applications focusing on estrogen receptor modulation and the investigation of calcium channel dynamics in smooth muscle tissues. -
FTO Inhibitor
Meclofenamic acid is a highly selective inhibitor of the fat mass and obesity-associated (FTO) enzyme, which plays a crucial role in the regulation of m(6)A RNA methylation. By competing with FTO for binding to m(6)A-containing nucleic acids, it modulates RNA metabolism and influences cellular processes related to metabolism and obesity. Additionally, Meclofenamic acid exhibits non-selective blockade of gap junctions and inhibits the potassium channels hKv2.1 and hKv1.1, with IC50 values of 56.0 µM and 155.9 µM, respectively. This compound is valuable for research applications focused on obesity, metabolic regulation, and ion channel physiology. -
Anticonvulsant Agent
Methsuximide is an anticonvulsant agent that primarily targets T-type calcium channels. It is effective in managing petit mal seizures, as well as psychomotor and focal motor attacks. This compound is utilized in neurological research to investigate seizure mechanisms and the pharmacological modulation of epilepsy. Its selective action on calcium currents makes it a valuable tool for studying seizure activity and potential therapeutic interventions. -
Chemical Compound
N-Bromoacetamide is a chemical compound that functions by irreversibly modulating sodium channel inactivation at the cytoplasmic membrane. This action also leads to a reduction in the rapid inactivation of potassium currents. It is primarily utilized in research focused on ion channel dynamics and electrophysiological studies. -
Antidepressant
Depramine, a tricyclic antidepressant, primarily targets neurotransmitter reuptake mechanisms, elevating levels of norepinephrine and serotonin in the synaptic cleft. It exhibits significant biological activity through the inhibition of acetylcholinesterase, Mg2+-ATPase, and Na+/K+ ATPase. Depramine is utilized in research focused on depression and related mood disorders, facilitating studies on neurotransmitter dynamics and cellular signaling pathways involved in antidepressant efficacy. -
Local Anaesthetic
Isobutamben is an amino ester-type local anaesthetic that primarily targets sodium channels to inhibit nerve conduction. It exhibits potent analgesic effects, making it useful in various surgical and dental procedures. Its ability to provide localized pain relief positions Isobutamben as a valuable tool in both clinical and research settings focused on pain management and anaesthesia. -
Topical Anesthetic
Quinisocaine is a local anesthetic primarily targeting sodium channels to inhibit nerve signal propagation. It is utilized in the investigation of pain mechanisms and pruritus in various research contexts. This compound provides valuable insights into anesthetic mechanisms and can facilitate studies on pain management efficacy. -
T-channels Inhibitor
1-Octanol is a saturated fatty alcohol that selectively inhibits T-type calcium channels, demonstrating an IC50 of 4 μM for native T-currents. This compound serves as a valuable tool in pharmacological research aimed at understanding calcium signaling pathways. Additionally, its properties as a biofuel with diesel-like characteristics make it an interesting candidate for energy applications. -
Nav1.7 Inhibitor
Nav1.7-IN-22 is a selective inhibitor of the voltage-gated sodium channel Nav1.7. By blocking the activity of Nav1.7, this compound effectively inhibits abnormal electrical signal generation and conduction in sensory neurons. Nav1.7-IN-22 is utilized in research focused on pain mechanisms, providing insights into potential therapeutic applications for pain management. -
Stable Isotope
Norquetiapine-d8 is a stable isotope labeled version of Norquetiapine, which acts as a selective inhibitor of HCN1 channels with an IC50 of 13.9 μM. This compound effectively inhibits noradrenaline reuptake and serves as a partial agonist at the 5-HT1A receptor (Ki = 45 nM), while also antagonizing presynaptic α2 (Ki = 237 nM), 5-HT2C (Ki = 107 nM), and 5-HT7 (Ki = 76 nM) receptors. Furthermore, Norquetiapine exhibits state-dependent blockade of the human cardiac sodium channel Nav1.5 and demonstrates partial anti-inflammatory activity in LPS-injected C57BL/6 mice, making it useful for research on depression and inflammation. -
Stable Isotope
Cyclopiazonic acid-13C20 is a stable isotope-labeled derivative of Cyclopiazonic acid, a selective inhibitor of endoplasmic reticulum calcium ATPases (ECAs) and has demonstrated efficacy against human respiratory syncytial virus (RSV) with an EC50 value of 4.13 μM. This compound is shown to inhibit the antagonistic effects of serotonin receptors in rat thoracic aorta, induce p53-dependent apoptosis, and exhibit reproductive toxicity in mouse testes, as well as inhibit the biological activation of aflatoxin B. Cyclopiazonic acid-13C20 is valuable for research applications in calcium signaling, viral infections, and toxicology studies. -
Insecticide
Fenpropathrin is a synthetic pyrethroid insecticide that primarily targets insect sodium channels, resulting in prolonged depolarization and subsequent paralysis of pests. This compound demonstrates significant insecticidal activity, effectively controlling a variety of agricultural pests. Additionally, research indicates that Fenpropathrin exposure may be linked to the development of parkinsonian symptoms, making it a subject of interest in neurotoxicology studies. Its utility in both agricultural and biomedical research applications highlights its importance in understanding insecticide mechanisms and potential health impacts.
