• Sign In
  • FAQ
  • Create an Account
Currency
USD currency flagUSD
Toggle Nav
My Cart
Menu
Account
Settings
Currency
USD currency flagUSD
  • Home
  • Membrane Transporters-Ion Channels

Membrane Transporters-Ion Channels

Shop By
Clear All

Items 1-50 of 957

Page
per page
Set Descending Direction
Catalog No.
Product Name
Application
Product Information
Citations
  1. A10758
    PTC124 (Ataluren)

    CFTR inhibitor

    PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
    Quick View
  2. A13344
    Pico145

    TRPC1/4/5 channels inhibitor

    Pico145 is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (?)-englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8.
    Quick View
  3. A13647
    (-)-Blebbistcitin

    myosin II inhibitor

    Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.
    Quick View
  4. A15810
    7ACC1

    MCT Inhibitor?€?

    7ACC1 selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.
    Quick View
  5. A12755
    Ouabain

    a-K-ATPase inhibitor

    Ouabain is a selective Na+, K+-ATPase inhibitor.
    Quick View
  6. A12897
    CFTRinh-172

    CFTR inhibitor

    CFTRinh-172 is a voltage-independent, selective CFTR inhibitor
    Quick View
  7. A13723
    CFTR-Inhibitor-II

    CFTR inhibitor

    CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM).
    Quick View
  8. A15865
    RSL3

    Ferroptosis inhibitor

    RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.
    Quick View
  9. A14242
    Digoxin

    sodium-potassium pump inhibitor

    Digoxin is a sodium-potassium pump inhibitor.
    Quick View
  10. A16398
    Ambroxol HCl

    Sodium Channel inhibitor

    AmbroxolHCl is a potent inhibitor of the neuronal Na+ channels, inhibits TTX-resistant Na+ currents with IC50 of 35.2 uM and 22.5 μM for tonic and phasic block, inhibits TTX-sensitive Na+ currents with IC50 of 100 μM. Phase 3.
    Quick View
  11. A20445
    Nanvuranlat (JPH203)

    LAT-1 inhibitor

    JPH203 is a potent and selective L-type amino acid transporter 1 (LAT-1) inhibitor.
    Quick View
  12. A20786
    Pyr10

    TRPC3 inhibitor

    Pyr10is a novel TRPC3-selective inhibitor, IC50 of Ca2+ influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 0.72 uM and 13.08 uM.
    Quick View
  13. A12324
    Elacridar (GF120918)

    P-gp & BCRP inhibitor

    Elacridaris a prototypical BCRP inhibitor which inhibits the Bcrp1-mediated transport.
    Quick View
  14. A14186
    AZD-3965

    MCT1 inhibitor

    AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.
    Quick View
  15. A13822
    Erastin

    VDAC inhibitor

    Erastin is a cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality in cells with H-Ras mutations.
    Quick View
  16. A11584
    Tariquidar (XR9576)

    P-gp inhibitor

    Tariquidar (XR9576) is a P-glycoprotein drug efflux pump inhibitor.
    Quick View
  17. A11293
    AR-C155858

    MCT1 and MCT2 inhibitor

    AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
    Quick View
  18. A11961
    Bafilomycin A1

    ATPase inhibitor

    Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
    Quick View
  19. A10645
    Nimodipine

    Calcium Channel inhibitor

    Nimodipine is a L-type Ca2+ channel blocker.
    Quick View
  20. A20092
    EIPA

    TRPP3 channel inhibitor

    EIPA (L593754; MH 12-43) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA (L593754; MH 12-43) also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
    Quick View
  21. A16103
    GsMTx4

    MSCs Inhibitor

    GsMTX4 is a 34 amino acid peptidyl toxin isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family.
    Quick View
  22. A11080
    PSC-833 (Valspodar)

    MDR1/P-gp Inhibitor

    PSC-833 is a kind of P-glycoprotein (P-gp) modulator that inhibits P-gp-mediated multidrug-resistance (MDR).
    Quick View
  23. A10724
    Phlorizin (Phloridzin)

    SGLT1/SGLT2 inhibitor

    Phlorizin is a competitive inhibitor of SGLT1 and SGLT2; this reduces renal glucose transport, lowering the amount of glucose in the blood.
    Quick View
  24. A10669
    Oligomycin A

    ATPase inhibitor

    Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane.
    Quick View
  25. A14011
    Tenapanor

    NHE3 inhibitor

    Tenapanor acts as an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body.
    Quick View
  26. A13372
    CHC

    MCT inhibitor

    CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas; decreases glycolytic metabolism, migration, and invasion in U251 cells.
    Quick View
  27. A10285
    Dapagliflozin (BMS512148)

    SGLT2 inhibitor

    Dapagliflozin inhibits subtype 2 of the sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney.
    Quick View
  28. A20954
    Minocycline hydrochloride

    HIF-1α inhibitor

    Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic, acting by binding to the bacterial 30S ribosomal subunit and inhibiting protein synthesis.
    Quick View
  29. A16817
    Canagliflozin hemihydrate

    SGLT2 inhibitor

    Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.
    Quick View
  30. A15236
    SEA0400

    NCX inhibitor

    SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger with IC50 of 5-33 nM (inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia).
    Quick View
  31. A11100
    Canagliflozin

    SGLT2 Inhibitor

    Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2).
    Quick View
  32. A12582
    Selinexor (KPT-330)

    CRM1 inhibitor

    KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
    Quick View
  33. A10078
    Aniracetam

    AMPA Receptor Inhibitor

    Aniracetam is an ampakine and nootropic of the racetam chemical class purported to be considerably more potent than piracetam.
    Quick View
  34. A10081
    Apigenin

    Protein kinase inhibitor

    Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

    Quick View
  35. A10155
    EGT1442

    SGLT2 inhibitor

    EGT1442 is a potent and selective SGLT2 inhibitor.
    Quick View
  36. A10365
    Esomeprazole sodium

    Proton pump inhibitor

    Esomeprazole sodium is a proton pump inhibitor which reduces acid secretion through inhibition of the H+ / K+ ATPase in gastric parietal cells.
    Quick View
  37. A10430
    Glimepiride

    Kir6.2/SUR inhibitor

    Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus.
    Quick View
  38. A10513
    Lansoprazole

    proton pump inhibitor

    Lansoprazole(AG 1749) is a proton pump inhibitor which prevents the stomach from producing acid.
    Quick View
  39. A10541
    Luteolin

    PDE4 inhibitor

    Luteolin is a PDE4 inhibitor, phosphodiesterase inhibitor, and an interleukin 6 inhibitor, affecting xylazine/ketamine-induced anesthesia in mice. Luteolin acts as a monoamine transporter activator, and is one of the few chemicals demonstrated to possess this property.
    Quick View
  40. A10672
    Omeprazole

    ATPase Inhibitors

    Omeprazole is a cell-permeable, selective proton pump inhibitor.
    Quick View
  41. A10675
    Oridonin (Isodonol)

    CFTR Inhibitor

    Oridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy.
    Quick View
  42. A10783
    Repaglinide

    Potassium Channel inhibitor

    Repaglinide is a potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell.
    Quick View
  43. A10854
    Sodium orthovanadate

    protein tyrosine phosphatases inhibitor

    Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
    Quick View
  44. A10921
    Tetrandrine (Fanchinine)

    Calcium Channel inhibitor

    Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis.
    Quick View
  45. A11102
    PF-04971729

    SGLT2 inhibitor

    PF-04971729 is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2.
    Quick View
  46. A10383
    Felodipine

    Calcium channel antagonist

    Felodipine is a 1,4-dihydropyridine antagonist and calcium channel protein inhibitor.

    Quick View
  47. A17650
    Desipramine Hydrochloride

    noradrenalin transporters inhibitor

    Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).

    Quick View
  48. A22590
    AER-271

    AQP4 inhibitor

    AER-271, a phosphonate prodrug derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke.
    Quick View
  49. A22608
    LASSBio-1135

    TRPV1 antagonist and TNF-alpha production inhibitor

    LASSBio-1135 is a dual TRPV1 antagonist and TNF-alpha production inhibitor.
    Quick View
  50. A22612
    VU590

    ROMK inhibitor

    VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney.
    Quick View

Items 1-50 of 957

Page
per page
Set Descending Direction
Shop By
Now Shopping by
  1. Actions
    Inhibitor
Clear All
Shopping Options
Category