Catalog No.
Product Name
Application
Product Information
Citations
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Antitumor Compound
S 16317 is an orally active dihydropyridine derivative that demonstrates low affinity for calcium channels (Ki: 0.55 μM). It effectively inhibits P-glycoprotein-mediated efflux of doxorubicin (ADR), thus potentially reversing multidrug resistance in tumor cells. This compound is particularly relevant for research in cancer biology and the development of novel therapeutic strategies against resistant tumors. -
Calcium Channel Inhibitor
TTA-P1 is a potent inhibitor of human T-type calcium channels, exhibiting state-independent characteristics. This compound is crucial for studying various physiological processes such as neuronal burst firing, hormone secretion, and cell proliferation. TTA-P1 is particularly valuable for research related to absence epilepsy and other neurological disorders linked to calcium signaling. -
N-type Calcium Channel Antagonist
Huwentoxin XVI is a selective antagonist of N-type calcium channels, demonstrating a potent inhibitory effect with an IC50 of approximately 60 nM. Derived from the Chinese tarantula Ornithoctonus huwena, it serves as an analgesic and exhibits no activity against voltage-gated T-type calcium channels, potassium channels, or sodium channels. This specificity makes Huwentoxin XVI valuable in research aimed at understanding pain mechanisms and the role of calcium channels in various physiological processes. -
T-type Calcium Channel Antagonist
TTA-A8 is a potent T-type calcium channel antagonist, demonstrating an IC50 value of 31.3 nM in the FLIPR depolarization assay. This compound exhibits favorable pharmacokinetic properties, making it an ideal candidate for research applications focused on epilepsy and sleep disorders. Its short-acting profile allows for detailed studies into the physiological roles of T-type calcium channels in related conditions. -
Broad-Spectrum Antiepileptic Agent
JNJ-26990990 is a broad-spectrum antiepileptic agent that primarily targets voltage-gated sodium channels and N-type calcium channels. It exhibits significant anticonvulsant activity, making it suitable for the study of various seizure models. Although it shows minimal inhibition of human carbonic anhydrase-II with an IC50 of 110 μM, its primary applications lie in the investigation of epilepsy and related neurological disorders. -
Antihypertensive Agent
Vatanidipine hydrochloride is an orally active dihydropyridine (DHP) calcium channel blocker that primarily functions as an antihypertensive agent. It exhibits vasodilatory effects, resulting in reduced vascular resistance, and additionally inhibits the release of noradrenaline from sympathetic nerve endings. This dual action makes Vatanidipine hydrochloride valuable in research related to hypertension and cardiovascular health. -
Calcium Channel Inhibitor
Agelenin is a polypeptide composed of 35 amino acids, functioning primarily as a calcium channel inhibitor. Isolated from the Agelena opulenta spider, this compound exhibits structural similarity to insect-specific calcium channel inhibitors, making it a valuable tool for studying calcium signaling pathways. Research applications include investigations into neuromuscular transmission and calcium-dependent cellular processes. -
Sodium/Calcium Channel Blocker
KT 2-230 is a sodium and calcium channel blocker that exhibits significant anti-inflammatory properties. This compound is utilized in research applications focused on neuropathic pain and various inflammatory conditions. Its ability to modulate ion channel activity makes it a valuable tool for studying the underlying mechanisms of synaptic transmission and neuroprotection. -
L-/T-type Calcium Channel Inhibitor
HM12 is a covalent inhibitor targeting L-/T-type calcium channels, specifically Cav1.2 and Cav3.2, while demonstrating selectivity for N-type channels. This compound induces irreversible inhibition that remains effective post-washout, making it a valuable tool for investigating calcium channel dynamics. HM12 is applicable in research focused on various diseases, including hypertension, pain, and epilepsy, facilitating the exploration of calcium channel modulation in therapeutic contexts. -
Ca2+ Channel α2δ Ligand
PD-0299685 is a potent ligand for the Ca2+ channel α2δ subunit. This compound exhibits significant potential in the study of refractory genito-urinary pain conditions, including interstitial cystitis and bladder pain syndrome. Its ability to modulate calcium channel activity makes it a valuable tool in pain research and related therapeutic investigations. -
Calcium Antagonists
KT-362 free acid is an intracellular calcium antagonist that exhibits antiarrhythmic and vasodilatory properties. It antagonizes norepinephrine-induced vasoconstriction by reducing inositol phospholipid hydrolysis, leading to decreased intracellular calcium mobilization. This reagent is suitable for investigating the mechanisms of contraction and relaxation in vascular smooth muscle, particularly the roles of intracellular calcium dynamics and inositol phospholipid pathways in vascular contraction. -
Calcium Channel Blocker
RS-5773 is a calcium channel blocker that acts as a congener of diltiazem. This compound exhibits antianginal properties and is distinguished by its minimal impact on hypotension and atrioventricular conduction, making it suitable for cardiovascular research. RS-5773 can be utilized in studies focused on calcium dynamics in cardiac function and related therapeutic applications. -
Ca2+-Channel Antagonist
Monatepil maleate is a potent orally active calcium channel antagonist that functions as a noncompetitive ACAT inhibitor. It has demonstrated the ability to decrease blood pressure and enhance plasma lipid metabolism. This compound shows promise for research applications related to hyperlipidemia and cardiovascular health. -
Calcium Antagonist
Semotiadil is a benzothiazine compound that functions as a calcium antagonist. It demonstrates significant antiplatelet activity, making it valuable for research into cardiovascular diseases and thrombotic disorders. Semotiadil can be used to explore mechanisms related to calcium signaling and its role in platelet function and aggregation. -
Calcium Channel Blocker
Nicardipine-d3 hydrochloride is a deuterium-labeled analog of Nicardipine hydrochloride, a potent calcium channel blocker. It effectively inhibits cardiac calcium channels, exhibiting an IC50 of 1 μM. This compound is utilized in research related to cardiovascular diseases, particularly for studying conditions such as chronic stable angina and hypertension management. -
Drug Derivative
PCA50941 is a 1,4-dihydropyridine derivative that primarily targets calcium channels. This compound exhibits potential biological activity in the modulation of cardiovascular function, making it useful for research in cardiovascular disease mechanisms. Its application extends to the exploration of novel therapeutic strategies in the treatment of hypertension and related cardiovascular conditions. -
Drug Impurity
Pregabalin impurity 3 is a recognized impurity associated with the drug Pregabalin, which primarily targets voltage-gated calcium channels. This compound may play a role in understanding the metabolic pathways and degradation processes of Pregabalin. Research applications of Pregabalin impurity 3 include method development for impurity analysis in pharmaceuticals and exploring potential interactions that could affect drug safety and efficacy. -
Ca2+ Inducer
D-myo-Inositol-1,3,4,5-tetrakisphosphate potassium acts as a Ca2+ inducer by enhancing extracellular calcium entry via the upregulation of voltage-gated calcium channels. This compound is instrumental in studies related to calcium signaling pathways and is often utilized in investigations of cellular processes influenced by calcium ions. It serves as a valuable reagent for researchers exploring the roles of calcium in various physiological and pathological contexts. -
Drug Impurity
Amlodipine impurity 3 is a specific impurity associated with the calcium channel blocker Amlodipine. This compound is significant for drug quality assessments and regulatory compliance in pharmaceutical research. It is utilized in the development and validation of analytical methods for the quantification and characterization of impurities in drug formulations. -
Dehydro Amlodipine Derivatives
Dehydro amlodipine fumarate is a derivative of dehydro amlodipine, primarily formed through the forced degradation of dehydro amlodipine under oxidative and acidic conditions. This compound is utilized in chemical research to study the stability and degradation pathways of dihydropyridine calcium channel blockers. It serves as a crucial intermediate in understanding the pharmacological properties and metabolic fate of calcium channel antagonists in various biological systems. -
Drug Impurity
Amlodipine impurity 6 is a specific impurity associated with Amlodipine, a calcium channel blocker. This compound is primarily utilized in analytical and quality control applications to ensure the purity of Amlodipine formulations. Its characterization is crucial for regulatory compliance and the development of safe and effective therapeutic agents. -
Drug Impurity
Amlodipine impurity 8 is a drug impurity associated with Amlodipine, a calcium channel blocker. This impurity may arise during the synthesis of Amlodipine and is important for quality control and regulatory compliance in pharmaceutical development. It can also be utilized in analytical studies to assess the purity and stability of Amlodipine formulations. -
Drug Impurity
Amlodipine Impurity 1 is a synthesized impurity associated with Amlodipine, a calcium channel blocker. It is utilized primarily in drug analysis and quality control to ensure the purity and safety of pharmaceutical formulations. This compound can serve as a reference standard in research and development, aiding in the identification and quantification of impurities in Amlodipine products. -
Drug Impurity
Clevidipine butyrate impurity 1 is a known impurity of Clevidipine butyrate, which is a calcium channel blocker used in the management of hypertension. This compound serves as a reference standard for analytical tests and quality control assessments in pharmaceutical development. Researchers can utilize this impurity to ensure the purity and safety of drug formulations containing Clevidipine butyrate. -
Auxin Transport Inhibitor
3,4,5-Triiodobenzoic acid is an auxin transport inhibitor that modulates auxin distribution in plant systems. This compound enhances specific [3H]verapamil binding in zucchini microsomes and rabbit skeletal muscle membranes, highlighting its potential role in studying calcium channel interactions. 3,4,5-Triiodobenzoic acid is valuable for research focused on smooth muscle contraction and the biochemical pathways influencing plant hormone transport. -
Ca2+ Channel Inhibitor
Ethaverine hydrochloride is a potent inhibitor of L-type calcium channels, primarily affecting cardiac tissues. It serves as a peripheral vasodilator and antispasmodic agent, demonstrating significant biological activity in relaxing smooth muscle. This compound is commonly utilized in research related to peripheral vascular disease and its associated disorders.
