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Catalog No.
Product Name
Application
Product Information
Citations
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serotonin transporter (SER) inhibitor
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. -
Serotonin transporter inhibitor
Imipramine Hydrochloride is a tricyclic antidepressant. Inhibits the serotonin and norepinephrine transporters but has little effect on the dopamine transporter. -
serotonin reuptake inhibitor
Azaphen is a potent inhibitor of the reuptake of serotonin. -
serotonin uptake inhibitor
Paroxetine Mesylate is a serotonin uptake inhibitor that is effective in the treatment of depression. -
serotonin-norepinephrine reuptake inhibitor
Nitroxazepine is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor. -
dual NE/DA transporter inhibitor
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. -
Serotonin reuptake inhibitor (SSRI)
Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM. -
triple reuptake inhibitor
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. -
triple reuptake inhibitor
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. -
noradrenalin transporters inhibitor
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
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Serotonin Transporter Inhibitor
Lubazodone hydrochloride is a selective serotonin transporter inhibitor that primarily modulates serotonin levels in the central nervous system. Its biological activity is associated with antidepressant effects, making it a valuable compound for research into the treatment of depression and related mood disorders. This reagent can aid in the exploration of serotonin dynamics and its implications in various neurobiological studies. -
Serotonin Reuptake Inhibitor
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter, resulting in increased serotonergic neurotransmission. This compound is utilized for its antidepressant properties and is effective in the treatment of major depressive disorder and anxiety-related conditions. Research applications include studies on mood regulation and neurotransmitter dynamics. -
Serotonin Transporter Inhibitor
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter. It is primarily used in the treatment of obsessive-compulsive disorder and depression by increasing serotonin levels in the synaptic cleft. This compound is valuable in research applications exploring mood regulation, anxiety disorders, and the neural mechanisms underlying depression. -
SERT Inhibitor
SERT-IN-2 is a potent serotonin transporter (SERT) inhibitor, demonstrating an IC50 of 0.58 nM. This compound exhibits significant anti-depressive activity and shows a high bioavailability of 83.28% in rat models. Additionally, SERT-IN-2 possesses the ability to cross the blood-brain barrier, making it a valuable tool for research into mood disorders and related pharmacological studies. -
Serotonin Reuptake Inhibitor
(S)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily utilized in the treatment of major depressive disorder and anxiety disorders. By increasing serotonin levels in the brain, it enhances mood and alleviates symptoms of depression. This compound is frequently employed in pharmacological studies related to depression, anxiety, and other mood disorders, making it valuable for researchers exploring therapeutic interventions in neuropsychology. -
NET/SERT Inhibitor
Desmethyl Sibutramine hydrochloride is a potent norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. As a secondary metabolite of Sibutramine, it plays a significant role in modulating neurotransmitter levels associated with appetite regulation. This compound is utilized in research focused on obesity and the development of appetite suppressant therapies. -
NET/SERT Inhibitor
Ampreloxetine hydrochloride is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT), with no activity against the dopamine transporter (DAT). It shows binding affinities with EC50 values of 11.7 ng/mL for NET and 50.8 ng/mL for SERT in plasma. This compound is utilized in research related to mood disorders and anxiety, offering insights into the modulation of norepinephrine and serotonin levels within the central nervous system. -
Serotonin Reuptake Inhibitor
(R)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily targeting the serotonin transporter. This compound demonstrates a modest affinity for the 5-HT2A and 5-HT2C receptors, contributing to its pharmacological profile. It is widely utilized in research related to depression, anxiety disorders, and other serotonin-related dysfunctions. -
Serotonin Transporter Inhibitor
Dapoxetine-d7 hydrochloride is a deuterium-labeled derivative of Dapoxetine hydrochloride, specifically targeting the serotonin transporter. This compound acts as a selective serotonin reuptake inhibitor (SSRI) with a short duration of action. Dapoxetine-d7 hydrochloride is employed in pharmacokinetic studies, providing insights into the metabolism and distribution of SSRIs in biological systems. -
NET/SERT Inhibitor
Desmethyl Sibutramine is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT). This compound demonstrates significant biological activity in modulating neurotransmitter levels, making it a valuable tool in obesity research and the study of appetite suppression mechanisms. Its metabolic profile and pharmacological effects contribute to its utility in understanding weight management therapies. -
Serotonin Transporter Inhibitor
Wy-45494 hydrochloride is a potent serotonin transporter inhibitor deriving from the selective norepinephrine and serotonin reuptake inhibitor venlafaxine, primarily formed via cytochrome P450 CYP3A4 metabolism. This compound demonstrates significant biological activity by inhibiting norepinephrine and serotonin reuptake, with IC50 values of 4.7 μM and 1.6 μM, respectively, in rat synaptosomal preparations. In animal studies, it effectively reverses reserpine-induced hypothermia in mice, establishing its potential utility in research related to mood disorders and neurotransmitter regulation. -
Serotonin-norepinephrine Reuptake Inhibitor
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that plays a critical role in investigating the pathophysiology of depression and related mood disorders. By modulating the levels of serotonin and norepinephrine in the synaptic cleft, Ansofaxine enhancing neurotransmitter availability and activity. This compound is valuable for research applications focused on the mechanisms of action of SNRIs in the treatment of depression and for exploring new therapeutic strategies. -
SSRI Inhibitor
Paroxetine maleate is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter (SERT). It exhibits significant efficacy in modulating serotonergic activity, making it valuable in the study of mood and anxiety disorders. Paroxetine maleate is commonly utilized in research related to generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and chronic headache conditions. -
Serotonin Transporter Inhibitor
(R)-Duloxetine hydrochloride is a selective serotonin transporter inhibitor primarily used in pharmacological studies. It demonstrates significant binding affinity and is of interest in investigations related to serotonin reuptake mechanisms. Unlike its enantiomer (S)-Duloxetine, (R)-Duloxetine has limited effectiveness as a dual reuptake inhibitor for serotonin and norepinephrine, making it a valuable compound for research on monoaminergic neurotransmission and related disorders. -
NE Reuptake Inhibitor
Tampramine fumarate is a potent and selective noncompetitive inhibitor of norepinephrine (NE) reuptake. This compound exhibits significant antidepressant activity, making it a valuable tool for studying depression and its related mechanisms. Researchers can utilize Tampramine fumarate to investigate the role of NE reuptake inhibition in neuropharmacology and the development of antidepressant therapies. -
Serotonin Transporter Inhibitor
Nitroxazepine hydrochloride is a potent serotonin transporter inhibitor functioning as a tricyclic antidepressant (TCA). It enhances serotonergic and noradrenergic neurotransmission by inhibiting the reuptake of serotonin and norepinephrine, making it a valuable compound for research into the mechanisms of depression and related mood disorders. Its role in modulating serotonin levels also provides insights into the pharmacological treatment options for various psychiatric conditions. -
Serotonin Re-uptake Inhibitor
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine, acting as a potent serotonin reuptake inhibitor, with a Ki of 13 nM. This compound is primarily utilized in research focusing on the pathophysiology and treatment of depression. Its selective inhibition of serotonin reuptake makes it an essential tool for studying serotonergic signaling and therapeutic interventions in mood disorders. -
Serotonin Reuptake Inhibitor
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that is orally active. It has been primarily investigated for its biological activity in the treatment of premature ejaculation (PE). Dapoxetine's mechanism of action enhances serotonergic signaling, contributing to increased ejaculatory control and prolonged intravaginal ejaculatory latency. This makes Dapoxetine a valuable reagent in sexual health research and studies focused on sexual dysfunction. -
Norepinephrine Reuptake Inhibitor
Tametraline is a norepinephrine reuptake inhibitor that modulates the levels of norepinephrine in the synaptic cleft. This compound exhibits significant antidepressant activity and is primarily utilized in research investigating neurological disorders, particularly depression. Its mechanism of action may provide insights into the treatment and understanding of mood-related pathologies. -
SerT Inhibitor
SERT-IN-3 is a potent inhibitor of the serotonin transporter (SerT), displaying an IC50 value of 34.4 nM in pharmacological assays. This compound plays a critical role in research applications focused on serotonin modulation, making it a valuable tool for studying neuropharmacology and potential therapeutic interventions in mood and anxiety disorders. -
Serotonin Transporter Inhibitor
(±)-Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor targeting the serotonin transporter. This compound exhibits significant analgesic and antidepressant properties, making it valuable in studies related to diabetic neuropathic pain, fibromyalgia, and major depressive disorder. Researchers utilize (±)-Duloxetine hydrochloride to explore its potential therapeutic effects and underlying mechanisms in various neuropathic and mood disorders. -
Serotonin Transporter Inhibitor
(S)-Venlafaxine is a potent serotonin transporter inhibitor that also affects norepinephrine reuptake. This compound is recognized for its antidepressant properties and is utilized in research to investigate mechanisms of mood disorders and neuropharmacology. Its dual inhibitory action on 5-HT and NE transporters makes it a valuable tool for studying depression and anxiety-related pathways. -
Dual Serotonin and Noradrenaline Monoamine reuptake Inhibitor
SNRI-IN-1 is a dual serotonin and noradrenaline monoamine reuptake inhibitor that demonstrates significant activity in modulating neurotransmitter levels. With a P-glycoprotein Efflux Ratio of 20, this compound is useful in studying the dynamics of monoamine transport and its implications in mood disorders and cognitive function. Research applications include investigating the effects of dual inhibition on neurotransmission and potential therapeutic benefits in conditions such as depression and anxiety. -
Serotonin-norepinephrine Reuptake Inhibitor
Duloxetine-d3 hydrochloride is a deuterium-labeled derivative of Duloxetine hydrochloride, functioning as a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. This compound is primarily utilized in research to study the pharmacokinetics and biological effects of Duloxetine in models of major depressive disorder and generalized anxiety disorder. Its stable isotope labeling enables precise tracking in metabolic studies and enhances the understanding of drug metabolism and action mechanisms. -
5-hydroxytryptamine Uptake Inhibitor
Serotonin azidobenzamidine is a selective inhibitor of 5-hydroxytryptamine (serotonin) uptake, functioning through competitive inhibition. It demonstrates significant biological activity with a Ki value of 130 nM, effectively inhibiting [3H]5-hydroxytryptamine uptake in rat cortical synaptosomes. This reagent is valuable in neuropharmacological research, aiding in the study of serotonin modulation and its effects on various physiological processes. -
Serotonin Transporter Inhibitor
(S)-Tomoxetine hydrochloride is a selective serotonin transporter inhibitor known for its ability to modulate serotonin levels in synaptic clefts. With a reported inhibition constant (Ki) of 16.8 nM, it effectively inhibits the reuptake of norepinephrine, thereby influencing neurotransmitter dynamics. This compound is utilized in research focused on neuropharmacology, mood disorders, and the mechanisms of serotonin signaling. -
Serotonin Reuptake Inhibitor
(S)-Norfluoxetine is a selective serotonin reuptake inhibitor that primarily targets the serotonin transporter. It has been shown to enhance allopregnanolone levels and decrease aggressive behavior in socially isolated murine models. This compound is valuable in research related to neuropharmacology and the understanding of mood and anxiety disorders. -
SERT Inhibitor
Nardosinonediol is a selective serotonin transporter (SERT) inhibitor. It demonstrates significant modulation of serotonin uptake, making it a valuable tool for studying serotonin-related pathways. This compound is primarily used in research focused on neuropharmacology, mood disorders, and the development of antidepressant therapies. -
Serotonin Reuptake Inhibitor
(Rac)-Dapoxetine hydrochloride is a racemic mixture of Dapoxetine hydrochloride, a selective serotonin reuptake inhibitor (SSRI) that primarily targets serotonin transporters. This compound exhibits notable efficacy in the treatment of premature ejaculation (PE) and is valuable in research aimed at understanding this condition. Its pharmacological profile positions it as a significant tool for studying serotonin-related pathways in human sexual health. -
Serotonin Reuptake Inhibitor
DA-8031 is a selective serotonin reuptake inhibitor (SSRI) with oral bioavailability. It demonstrates the ability to modulate serotonin levels, making it a valuable compound for studying conditions related to serotonin dysregulation, particularly premature ejaculation (PE). This compound serves as an important tool for research into therapeutic interventions for PE and related disorders. -
Serotonin Reuptake Inhibitor
Lubazodone is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter. It exhibits significant antidepressant activity and is utilized in the investigation of various depressive disorders. Research applications include exploring its effects on mood regulation and neurochemical pathways associated with depression.
