Catalog No.
Product Name
Application
Product Information
Citations
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serotonin transporter (SER) inhibitor
Vilazodone Hydrochloride (EMD 68843 Hydrochloride) is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist. -
Serotonin transporter inhibitor
Imipramine Hydrochloride is a tricyclic antidepressant. Inhibits the serotonin and norepinephrine transporters but has little effect on the dopamine transporter. -
serotonin reuptake inhibitor
Azaphen is a potent inhibitor of the reuptake of serotonin. -
serotonin uptake inhibitor
Paroxetine Mesylate is a serotonin uptake inhibitor that is effective in the treatment of depression. -
serotonin-norepinephrine reuptake inhibitor
Nitroxazepine is a tricyclic antidepressant (TCA) for the treatment of depression. Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor. -
dual NE/DA transporter inhibitor
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively. -
Serotonin reuptake inhibitor (SSRI)
Escitalopram is a selective serotonin reuptake inhibitor (SSRI) with Ki of 0.89 nM. -
triple reuptake inhibitor
Dasotraline is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. -
triple reuptake inhibitor
Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively. -
noradrenalin transporters inhibitor
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters (Ki values are 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively).
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Serotonin Transporter Inhibitor
Lubazodone hydrochloride is a selective serotonin transporter inhibitor that primarily modulates serotonin levels in the central nervous system. Its biological activity is associated with antidepressant effects, making it a valuable compound for research into the treatment of depression and related mood disorders. This reagent can aid in the exploration of serotonin dynamics and its implications in various neurobiological studies. -
Serotonin Reuptake Inhibitor
Citalopram is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter, resulting in increased serotonergic neurotransmission. This compound is utilized for its antidepressant properties and is effective in the treatment of major depressive disorder and anxiety-related conditions. Research applications include studies on mood regulation and neurotransmitter dynamics. -
Serotonin Transporter Inhibitor
Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI) that targets the serotonin transporter. It is primarily used in the treatment of obsessive-compulsive disorder and depression by increasing serotonin levels in the synaptic cleft. This compound is valuable in research applications exploring mood regulation, anxiety disorders, and the neural mechanisms underlying depression. -
SERT Inhibitor
SERT-IN-2 is a potent serotonin transporter (SERT) inhibitor, demonstrating an IC50 of 0.58 nM. This compound exhibits significant anti-depressive activity and shows a high bioavailability of 83.28% in rat models. Additionally, SERT-IN-2 possesses the ability to cross the blood-brain barrier, making it a valuable tool for research into mood disorders and related pharmacological studies. -
Antidepressant Agent
ZZL-7 is a fast-onset antidepressant agent that targets the interaction between the serotonin transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN). By disrupting this interaction, ZZL-7 demonstrates significant potential in alleviating symptoms associated with major depressive disorder (MDD). Its ability to effectively cross the blood-brain barrier makes it a valuable tool for neuroscience research focused on the mechanisms underlying depression and the development of novel therapeutic strategies. -
Serotonin Reuptake Inhibitor
(S)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily utilized in the treatment of major depressive disorder and anxiety disorders. By increasing serotonin levels in the brain, it enhances mood and alleviates symptoms of depression. This compound is frequently employed in pharmacological studies related to depression, anxiety, and other mood disorders, making it valuable for researchers exploring therapeutic interventions in neuropsychology. -
NET/SERT Inhibitor
Desmethyl Sibutramine hydrochloride is a potent norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. As a secondary metabolite of Sibutramine, it plays a significant role in modulating neurotransmitter levels associated with appetite regulation. This compound is utilized in research focused on obesity and the development of appetite suppressant therapies. -
NET/SERT Inhibitor
Ampreloxetine hydrochloride is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT), with no activity against the dopamine transporter (DAT). It shows binding affinities with EC50 values of 11.7 ng/mL for NET and 50.8 ng/mL for SERT in plasma. This compound is utilized in research related to mood disorders and anxiety, offering insights into the modulation of norepinephrine and serotonin levels within the central nervous system. -
Serotonin Reuptake Inhibitor
(R)-Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor (SSRI) primarily targeting the serotonin transporter. This compound demonstrates a modest affinity for the 5-HT2A and 5-HT2C receptors, contributing to its pharmacological profile. It is widely utilized in research related to depression, anxiety disorders, and other serotonin-related dysfunctions. -
Serotonin Transporter Inhibitor
Dapoxetine-d7 hydrochloride is a deuterium-labeled derivative of Dapoxetine hydrochloride, specifically targeting the serotonin transporter. This compound acts as a selective serotonin reuptake inhibitor (SSRI) with a short duration of action. Dapoxetine-d7 hydrochloride is employed in pharmacokinetic studies, providing insights into the metabolism and distribution of SSRIs in biological systems. -
Methylphenidate Analogue
rel-HDMP 28 hydrochloride is a methylphenidate analogue that selectively targets the serotonin transporter (SERT), exhibiting an inhibition constant (Ki) of 105 nM. This compound demonstrates potential in research applications focused on modulating serotonergic activity and understanding its implications in neuropsychiatric disorders. Its selective binding profile makes it a valuable tool for pharmacological studies related to serotonin reuptake inhibition. -
SERT Enhancer
Adoxosidic acid acts as a serotonin transporter (SERT) enhancer, contributing to the modulation of serotonin levels in the brain. Derived from the plant N. jatamansi, it is utilized in antidepressant research to explore its potential therapeutic effects on mood disorders. This compound serves as a valuable tool for investigating the mechanisms underlying serotonin reuptake and its implications in depression treatment. -
NET/SERT Inhibitor
Desmethyl Sibutramine is an orally active inhibitor of the norepinephrine transporter (NET) and serotonin transporter (SERT). This compound demonstrates significant biological activity in modulating neurotransmitter levels, making it a valuable tool in obesity research and the study of appetite suppression mechanisms. Its metabolic profile and pharmacological effects contribute to its utility in understanding weight management therapies. -
Serotonin Transporter Inhibitor
Wy-45494 hydrochloride is a potent serotonin transporter inhibitor deriving from the selective norepinephrine and serotonin reuptake inhibitor venlafaxine, primarily formed via cytochrome P450 CYP3A4 metabolism. This compound demonstrates significant biological activity by inhibiting norepinephrine and serotonin reuptake, with IC50 values of 4.7 μM and 1.6 μM, respectively, in rat synaptosomal preparations. In animal studies, it effectively reverses reserpine-induced hypothermia in mice, establishing its potential utility in research related to mood disorders and neurotransmitter regulation. -
Serotonin-norepinephrine Reuptake Inhibitor
Ansofaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that plays a critical role in investigating the pathophysiology of depression and related mood disorders. By modulating the levels of serotonin and norepinephrine in the synaptic cleft, Ansofaxine enhancing neurotransmitter availability and activity. This compound is valuable for research applications focused on the mechanisms of action of SNRIs in the treatment of depression and for exploring new therapeutic strategies. -
SSRI Inhibitor
Paroxetine maleate is a selective serotonin reuptake inhibitor (SSRI) that primarily targets the serotonin transporter (SERT). It exhibits significant efficacy in modulating serotonergic activity, making it valuable in the study of mood and anxiety disorders. Paroxetine maleate is commonly utilized in research related to generalized anxiety disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and chronic headache conditions. -
Antidepressant
Oxaflozane is a non-tricyclic antidepressant that primarily targets serotonin receptors. It exhibits anti-cataleptic and anti-aggressive properties while also demonstrating a mild potentiation of amphetamine-induced stereotypic behaviors. This compound is useful for research on serotonin modulation and its implications in mood disorders. -
Antidepressant Agent
(S)-Alaproclate hydrochloride is a selective serotonin reuptake inhibitor (SSRI) with significant antidepressant properties. It exhibits a potent blockade of N-methyl-D-aspartate (NMDA) receptor currents in hippocampal neurons, with an IC50 value of 1.1 μM, and effectively inhibits K+ currents. This compound is valuable for research exploring mechanisms of depression and neuronal signaling pathways. -
Serotonin Transporter Inhibitor
(R)-Duloxetine hydrochloride is a selective serotonin transporter inhibitor primarily used in pharmacological studies. It demonstrates significant binding affinity and is of interest in investigations related to serotonin reuptake mechanisms. Unlike its enantiomer (S)-Duloxetine, (R)-Duloxetine has limited effectiveness as a dual reuptake inhibitor for serotonin and norepinephrine, making it a valuable compound for research on monoaminergic neurotransmission and related disorders. -
NE Reuptake Inhibitor
Tampramine fumarate is a potent and selective noncompetitive inhibitor of norepinephrine (NE) reuptake. This compound exhibits significant antidepressant activity, making it a valuable tool for studying depression and its related mechanisms. Researchers can utilize Tampramine fumarate to investigate the role of NE reuptake inhibition in neuropharmacology and the development of antidepressant therapies. -
Serotonin Transporter Inhibitor
Nitroxazepine hydrochloride is a potent serotonin transporter inhibitor functioning as a tricyclic antidepressant (TCA). It enhances serotonergic and noradrenergic neurotransmission by inhibiting the reuptake of serotonin and norepinephrine, making it a valuable compound for research into the mechanisms of depression and related mood disorders. Its role in modulating serotonin levels also provides insights into the pharmacological treatment options for various psychiatric conditions. -
Serotonin Re-uptake Inhibitor
(R)-Norfluoxetine is the (R)-enantiomer of Norfluoxetine, acting as a potent serotonin reuptake inhibitor, with a Ki of 13 nM. This compound is primarily utilized in research focusing on the pathophysiology and treatment of depression. Its selective inhibition of serotonin reuptake makes it an essential tool for studying serotonergic signaling and therapeutic interventions in mood disorders. -
Serotonin Reuptake Inhibitor
Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that is orally active. It has been primarily investigated for its biological activity in the treatment of premature ejaculation (PE). Dapoxetine's mechanism of action enhances serotonergic signaling, contributing to increased ejaculatory control and prolonged intravaginal ejaculatory latency. This makes Dapoxetine a valuable reagent in sexual health research and studies focused on sexual dysfunction. -
Serotonin Antagonist
Nor Mianserin Hydrochloride is a serotonin antagonist, acting primarily on serotonin receptors to modulate serotonergic signaling. This compound is utilized in research focused on disorders linked to serotonin metabolism, as well as conditions associated with histamine metabolism. Its pharmacological profile makes it a valuable tool for studying various neuropsychiatric and metabolic diseases. -
MDR Reversal Agent
Tampramine is a phenothiazine derivative that functions as a multidrug resistance (MDR) reversal agent. It demonstrates significant biological activity with effective doses (ED50) of 60 μM in both P388 and P388/ADR cell lines. Tampramine is primarily used in research to explore mechanisms of drug resistance and to enhance the efficacy of chemotherapeutic agents. -
SERT-nnos interaction Promoter
Sakura-6 is a SERT-nNOS interaction promoter that enhances the formation of the SERT-nNOS complex while concurrently decreasing the surface expression of SERT. Experimental administration of Sakura-6 into the dorsal raphe nucleus (DRN) results in the induction of depression-like behaviors in murine models. This compound is valuable for investigating the neurobiological mechanisms of serotonin transport and its implications in mood disorders. -
Norepinephrine Reuptake Inhibitor
Tametraline is a norepinephrine reuptake inhibitor that modulates the levels of norepinephrine in the synaptic cleft. This compound exhibits significant antidepressant activity and is primarily utilized in research investigating neurological disorders, particularly depression. Its mechanism of action may provide insights into the treatment and understanding of mood-related pathologies. -
SerT Inhibitor
SERT-IN-3 is a potent inhibitor of the serotonin transporter (SerT), displaying an IC50 value of 34.4 nM in pharmacological assays. This compound plays a critical role in research applications focused on serotonin modulation, making it a valuable tool for studying neuropharmacology and potential therapeutic interventions in mood and anxiety disorders. -
Serotonin Transporter Inhibitor
(±)-Duloxetine hydrochloride is a serotonin-norepinephrine reuptake inhibitor targeting the serotonin transporter. This compound exhibits significant analgesic and antidepressant properties, making it valuable in studies related to diabetic neuropathic pain, fibromyalgia, and major depressive disorder. Researchers utilize (±)-Duloxetine hydrochloride to explore its potential therapeutic effects and underlying mechanisms in various neuropathic and mood disorders. -
Serotonin Transporter Inhibitor
(S)-Venlafaxine is a potent serotonin transporter inhibitor that also affects norepinephrine reuptake. This compound is recognized for its antidepressant properties and is utilized in research to investigate mechanisms of mood disorders and neuropharmacology. Its dual inhibitory action on 5-HT and NE transporters makes it a valuable tool for studying depression and anxiety-related pathways. -
Fenfluramine Metabolite
Norfenfluramine is a major brain-penetrant metabolite of Fenfluramine that primarily interacts with 5-HT transporters, facilitating the release of serotonin from neurons. This compound has been observed to exhibit antiepileptic effects in vivo, making it relevant for research in neuropharmacology and the study of serotonin-related disorders. Its efficacy in modulating serotonin levels could provide insights into therapeutic strategies for epilepsy and other neurological conditions. -
Serotonin Transporter
MADAM is a highly selective compound that targets the serotonin transporter (5-HTT) with a Ki value of 1.6 nM. This compound has significant potential as a PET radiotracer, allowing for the visualization of the serotonin transporter in various research applications. Its high affinity for 5-HTT makes it a valuable tool for studying serotonin-related pathways and conditions. -
Dual Serotonin and Noradrenaline Monoamine reuptake Inhibitor
SNRI-IN-1 is a dual serotonin and noradrenaline monoamine reuptake inhibitor that demonstrates significant activity in modulating neurotransmitter levels. With a P-glycoprotein Efflux Ratio of 20, this compound is useful in studying the dynamics of monoamine transport and its implications in mood disorders and cognitive function. Research applications include investigating the effects of dual inhibition on neurotransmission and potential therapeutic benefits in conditions such as depression and anxiety. -
Guaiane-type Compound
Nardoguaianone J is a guaiane-type compound isolated from the roots of Nardostachys chinensis. This compound is known to enhance serotonin transporter (SERT) activity, making it relevant in studies related to serotonin signaling and neurotransmission. Nardoguaianone J is valuable for research into mood regulation, depression, and related neurological disorders. -
Serotonin-norepinephrine Reuptake Inhibitor
Duloxetine-d3 hydrochloride is a deuterium-labeled derivative of Duloxetine hydrochloride, functioning as a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM. This compound is primarily utilized in research to study the pharmacokinetics and biological effects of Duloxetine in models of major depressive disorder and generalized anxiety disorder. Its stable isotope labeling enables precise tracking in metabolic studies and enhances the understanding of drug metabolism and action mechanisms. -
5-hydroxytryptamine Uptake Inhibitor
Serotonin azidobenzamidine is a selective inhibitor of 5-hydroxytryptamine (serotonin) uptake, functioning through competitive inhibition. It demonstrates significant biological activity with a Ki value of 130 nM, effectively inhibiting [3H]5-hydroxytryptamine uptake in rat cortical synaptosomes. This reagent is valuable in neuropharmacological research, aiding in the study of serotonin modulation and its effects on various physiological processes. -
Venlafaxine Active Metabolite
Desvenlafaxine succinate is the succinate salt form of the primary active metabolite of Venlafaxine, serving as a selective inhibitor of serotonin and norepinephrine reuptake. It exhibits IC50 values of 47.3 nM for the human serotonin transporter (hSERT) and 531.3 nM for the human norepinephrine transporter (hNET), offering significant potential in modulating neurotransmitter levels. Additionally, Desvenlafaxine succinate demonstrates modest binding affinity at the human dopamine transporter, with 62% inhibition observed at a concentration of 100 μM. This compound is valuable for research in neuropsychiatric conditions and the study of antidepressant mechanisms. -
Serotonin Transporter Control
(1R,4R)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride primarily targets the serotonin transporter, influencing serotonin reuptake mechanisms. This compound serves as a metabolite of the selective serotonin reuptake inhibitor Sertraline, facilitating investigations into its pharmacodynamics and pharmacokinetics. Its relevance in researching mood disorders and antidepressant effects makes it a valuable tool for studies focused on serotonin modulation. -
Serotonin Transporter Inhibitor
(S)-Tomoxetine hydrochloride is a selective serotonin transporter inhibitor known for its ability to modulate serotonin levels in synaptic clefts. With a reported inhibition constant (Ki) of 16.8 nM, it effectively inhibits the reuptake of norepinephrine, thereby influencing neurotransmitter dynamics. This compound is utilized in research focused on neuropharmacology, mood disorders, and the mechanisms of serotonin signaling.
