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Tri-GalNAc-DBCO

Catalog No.: A81373
Protein degrader
Tri-GalNAc-DBCO is a synthetic ligand featuring three GalNAc units linked to DBCO, designed for use in protein degradation applications. It selectively targets the asialoglycoprotein receptor (ASGPR), facilitating the delivery of conjugated proteins or small molecules to lysosomes via receptor-mediated endocytosis. This targeted approach allows for the effective degradation of substrates, making Tri-GalNAc-DBCO a valuable tool in research focusing on lysosomal-targeted therapeutics and protein modulation strategies.
Tri-GalNAc-DBCO 2999748-27-3 Protein degrader
Grouped product items
Size Price Stock Qty
1mg
$225.00
In stock
5mg
$640.00
In stock
10mg
$1,050.00
In stock
25mg
$2,015.00
In stock
50mg
$3,155.00
In stock
100mg
$4,960.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionTri-GalNAc-DBCO is a synthetic ligand featuring three GalNAc units linked to DBCO, designed for use in protein degradation applications. It selectively targets the asialoglycoprotein receptor (ASGPR), facilitating the delivery of conjugated proteins or small molecules to lysosomes via receptor-mediated endocytosis. This targeted approach allows for the effective degradation of substrates, making Tri-GalNAc-DBCO a valuable tool in research focusing on lysosomal-targeted therapeutics and protein modulation strategies.
Product Information
Catalog NumA81373
FormulaC82H127N11O29
Molecular Weight1730.94
CAS Number2999748-27-3
SMILESO=C(NCCCNC(CCCCO[C@H](O[C@@H]1CO)[C@@H]([C@H]([C@H]1O)O)NC(C)=O)=O)CCOCC(COCCC(NCCCNC(CCCCO[C@H](O[C@@H]2CO)[C@@H]([C@H]([C@H]2O)O)NC(C)=O)=O)=O)(NC(CCCCC(N3CC4=CC=CC=C4C#CC5=CC=CC=C53)=O)=O)COCCC(NCCCNC(CCCCO[C@H](O[C@@H]6CO)[C@@H]([C@H]([C@H]6O)O)NC(C)=O)=O)=O
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