Trihexyphenidyl is a selective M1 muscarinic receptor antagonist, with an IC50 of 3.7 nM for rat cerebral cortex M1 receptors. It modulates cholinergic activity, effectively countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl is utilized in research for Parkinson's disease and demonstrates efficacy in improving movement disorders, as well as inhibiting vagally-induced bradycardia and vasodilation. Its inhibition of McN-A-343-induced pressor responses highlights its potential in studying neurophysiological effects.
Trihexyphenidyl is a selective M1 muscarinic receptor antagonist, with an IC50 of 3.7 nM for rat cerebral cortex M1 receptors. It modulates cholinergic activity, effectively countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl is utilized in research for Parkinson's disease and demonstrates efficacy in improving movement disorders, as well as inhibiting vagally-induced bradycardia and vasodilation. Its inhibition of McN-A-343-induced pressor responses highlights its potential in studying neurophysiological effects.
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