Trovafloxacin is a broad-spectrum quinolone antibiotic that primarily targets DNA gyrase and topoisomerase IV, exhibiting potent activity against Gram-positive, Gram-negative, and anaerobic bacteria. In addition to its antibacterial effects, Trovafloxacin is a selective inhibitor of the pannexin 1 channel (PANX1) with an IC50 of 4 μM, effectively modulating PANX1 inward current. Furthermore, Trovafloxacin influences cellular processes by inducing dysregulated fragmentation of apoptotic cells through PANX1 inhibition. This dual activity positions Trovafloxacin as a valuable reagent for research in microbiology and cell biology.
Trovafloxacin is a broad-spectrum quinolone antibiotic that primarily targets DNA gyrase and topoisomerase IV, exhibiting potent activity against Gram-positive, Gram-negative, and anaerobic bacteria. In addition to its antibacterial effects, Trovafloxacin is a selective inhibitor of the pannexin 1 channel (PANX1) with an IC50 of 4 μM, effectively modulating PANX1 inward current. Furthermore, Trovafloxacin influences cellular processes by inducing dysregulated fragmentation of apoptotic cells through PANX1 inhibition. This dual activity positions Trovafloxacin as a valuable reagent for research in microbiology and cell biology.
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