Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation.
Tubulin/NEDDylation-IN-1 (compound C11) is a potent dual inhibitor targeting tubulin and NEDDylation, exhibiting an IC50 of 2.40 μM for tubulin. This compound effectively disrupts microtubule dynamics and inhibits the NEDDylation process, a crucial post-translational modification involving the attachment of the ubiquitin-like protein NEDD8 to target proteins. By forming hydrogen bonds with key residues in tubulin and the NEDD8 activating enzyme (NAE) through its methoxy and dithiocarbamate functionalities, Tubulin/NEDDylation-IN-1 demonstrates significant anti-proliferative activity and serves as a valuable tool for research investigating cellular proliferation and microtubule regulation.
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