Tubulin Polymerization-IN-1 prodrug is a palladium-mediated inhibitor of tubulin polymerization, developed to target the colchicine binding site. This prodrug demonstrates significantly reduced cytotoxicity compared to its parent compound, offering a 68.3-fold reduction in toxicity while maintaining effectiveness upon activation by Pd resin. Mechanistic investigations align its anticancer activity with that of colchicine binding site inhibitors. In vivo studies have shown that treatment with Tubulin Polymerization-IN-1 prodrug results in a substantial inhibition of tumor growth (63.2%) following Pd resin activation. This compound holds potential for advancing research in anticancer therapeutics.
Tubulin Polymerization-IN-1 prodrug is a palladium-mediated inhibitor of tubulin polymerization, developed to target the colchicine binding site. This prodrug demonstrates significantly reduced cytotoxicity compared to its parent compound, offering a 68.3-fold reduction in toxicity while maintaining effectiveness upon activation by Pd resin. Mechanistic investigations align its anticancer activity with that of colchicine binding site inhibitors. In vivo studies have shown that treatment with Tubulin Polymerization-IN-1 prodrug results in a substantial inhibition of tumor growth (63.2%) following Pd resin activation. This compound holds potential for advancing research in anticancer therapeutics.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
