Tyk2-IN-22 is a selective inhibitor of tyrosine kinase 2 (Tyk2) with a notable inhibition profile, exhibiting IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM against Tyk2, JAK1, and JAK3, respectively. This compound effectively inhibits downstream phosphorylation of STAT5, making it a valuable tool for studying Tyk2-mediated signaling pathways. Tyk2-IN-22 is suitable for research applications related to autoimmune diseases, inflammatory conditions, and cancer therapies targeting JAK-STAT signaling.
Tyk2-IN-22 is a selective inhibitor of tyrosine kinase 2 (Tyk2) with a notable inhibition profile, exhibiting IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM against Tyk2, JAK1, and JAK3, respectively. This compound effectively inhibits downstream phosphorylation of STAT5, making it a valuable tool for studying Tyk2-mediated signaling pathways. Tyk2-IN-22 is suitable for research applications related to autoimmune diseases, inflammatory conditions, and cancer therapies targeting JAK-STAT signaling.
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