Tyk2-IN-23 is a selective TYK2 inhibitor with an IC50 of 18 nM, demonstrating over 70-fold selectivity against JAK isoforms 1, 2, and 3. This compound effectively inhibits phosphorylated STAT3 in TYK2-dependent signaling pathways activated by interferon-alpha (IFN-α) and interleukin-10 (IL-10). Additionally, Tyk2-IN-23 significantly reduces IFN-α-induced STAT1 phosphorylation in H9 cells, making it a valuable tool for the investigation of alopecia areata and allergic rhinitis.
Tyk2-IN-23 is a selective TYK2 inhibitor with an IC50 of 18 nM, demonstrating over 70-fold selectivity against JAK isoforms 1, 2, and 3. This compound effectively inhibits phosphorylated STAT3 in TYK2-dependent signaling pathways activated by interferon-alpha (IFN-α) and interleukin-10 (IL-10). Additionally, Tyk2-IN-23 significantly reduces IFN-α-induced STAT1 phosphorylation in H9 cells, making it a valuable tool for the investigation of alopecia areata and allergic rhinitis.
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