U-104489 is a potent inhibitor of HIV-1, targeting the reverse transcriptase (RT) enzyme. It demonstrates Ki values of 0.13 μM against the wild-type p66/p51 variant (G190), and 0.12 μM against the G190A variant, while exhibiting significantly reduced activity (Ki > 100 μM) against the G190E variant. This compound is valuable for research applications aimed at understanding HIV-1 resistance mechanisms and developing effective antiretroviral therapies.
U-104489 is a potent inhibitor of HIV-1, targeting the reverse transcriptase (RT) enzyme. It demonstrates Ki values of 0.13 μM against the wild-type p66/p51 variant (G190), and 0.12 μM against the G190A variant, while exhibiting significantly reduced activity (Ki > 100 μM) against the G190E variant. This compound is valuable for research applications aimed at understanding HIV-1 resistance mechanisms and developing effective antiretroviral therapies.
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