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Publications citing Adooq Products
U0126-EtOH Citations (2)
- Byungki Jang,et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 29077055
- Choe YJ,et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. 24366007
Chemical Information
| Catalog Num | A10957 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 426.6 |
| Formula | C18H16N6S2.C2H6O |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1173097-76-1 |
| Synonyms | N/A |
| SMILES code | CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
| Chemical Name | (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile; ethanol |
Description |
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively. | ||||||||||||||||||||||||
Targets |
|
||||||||||||||||||||||||
| Solubility (25°C) * | In vitro | DMSO | 85 mg/mL (199.26 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | <1 mg/mL (<1 mM) | ||
| In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.44 mL | 117.21 mL | 234.41mL |
| 0.5 mM | 4.69 mL | 23.44 mL | 46.88 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.44 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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