U0126-EtOH

Catalog No.: A10957

MEK inhibitor

U0126-EtOH Chemical Structure

CAS NO. 1173097-76-1

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

Availability: In stock

Package Price Qty
25 mg

Regular Price: $60.00

Special Price $48.00

50 mg

Regular Price: $80.00

Special Price $64.00

100 mg

Regular Price: $110.00

Special Price $88.00

250 mg

Regular Price: $180.00

Special Price $144.00

10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
Targets
Target Value
MEK2IC50: 0.06μM
MEK1IC50: 0.07μM
PKCIC50: >10μM
CDK2IC50: >10μM
CDK4IC50: >10μM
MKK6/p38MAPKIC50: 20μM
MKK3/p38MAPKIC50: 38μM
ERK1/2IC50: >50μM
JNKIC50: >100μM
MKK4IC50: >100μM
AblIC50: >100μM
In vitro (25°C) DMSO 85 mg/mL (199.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.44 mL 117.21 mL 234.41 mL
0.5 mM 4.69 mL 23.44 mL 46.88 mL
1 mM 2.34 mL 11.72 mL 23.44 mL
5 mM 0.47 mL 2.34 mL 4.69 mL

*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10957
Actions Inhibitor
M. Wt 426.6
Formula C18H16N6S2.C2H6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1173097-76-1
SMILES CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N

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