Catalog No.: A10957
MEK inhibitor
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
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Product Name Price Stock Qty
U0126-EtOH 25mg
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U0126-EtOH 50mg
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U0126-EtOH 100mg
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U0126-EtOH 250mg
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U0126-EtOH 10mM * 1mL in DMSO
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's U0126-EtOH has been cited by 4 publications
  • Hanna Galganska, .et al. , Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
  • Paul Mark Medina, .et al. , Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
  • Byungki Jang, .et al. , Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
  • Choe YJ, .et al. , Int J Oncol., 2014, 44(3):761-8. PMID: 24366007
  • Biological Activity
    Discription U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
    Target Value
    Product Information
    Catalog Num A10957
    Formula C18H16N6S2.C2H6O
    Molecular Weight 426.6
    CAS Number 1173097-76-1
    SMILES CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    In vitro (25°C) DMSO Warmed: 77 mg/mL (180.51 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 5%DMSO+40%PEG300+5%Tween 80+50%H2O 4.03 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.44 mL 117.21 mL 234.41 mL
    0.5 mM 4.69 mL 23.44 mL 46.88 mL
    1 mM 2.34 mL 11.72 mL 23.44 mL
    5 mM 0.47 mL 2.34 mL 4.69 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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