- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
- Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007
Biological Activity
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
Targets
Target | Value |
---|---|
MEK2 | IC50: 0.06μM |
MEK1 | IC50: 0.07μM |
PKC | IC50: >10μM |
CDK2 | IC50: >10μM |
CDK4 | IC50: >10μM |
MKK6/p38MAPK | IC50: 20μM |
MKK3/p38MAPK | IC50: 38μM |
ERK1/2 | IC50: >50μM |
JNK | IC50: >100μM |
MKK4 | IC50: >100μM |
Abl | IC50: >100μM |
In vitro (25°C) | DMSO | 85 mg/mL (199.26 mM) | |
Water | <1 mg/mL (<1 mM) | ||
Ethanol | <1 mg/mL (<1 mM) | ||
In vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide | 30 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 23.44 mL | 117.21 mL | 234.41 mL |
0.5 mM | 4.69 mL | 23.44 mL | 46.88 mL |
1 mM | 2.34 mL | 11.72 mL | 23.44 mL |
5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10957 |
---|---|
Actions | Inhibitor |
M. Wt | 426.6 |
Formula | C18H16N6S2.C2H6O |
Solubility | DMSO |
Purity | >98% |
Storage | at -20°C 3 years Powder |
CAS No. | 1173097-76-1 |
SMILES | CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
PD0325901
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
RO4927350
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
GDC-0623
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
TAK-733
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
RO4987655
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineopl…
GDC-0973 (Cobimetinib)
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively f…
BI-847325
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xen…
GSK1120212 (JTP-74057, Trametinib)
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
Keywords:buy U0126-EtOH | U0126-EtOH Supplier | purchase | cost | manufacturer | order | distributor | buy 1173097-76-1| 1173097-76-1 Supplier | purchase 1173097-76-1 | 1173097-76-1 cost | 1173097-76-1 manufacturer | order 1173097-76-1 | 1173097-76-1 distributor