U0126-EtOH

Name: U0126-EtOH
SKU: A10957
Price: 25 USD
Rating: 5 (5 reviews)

Catalog No.: A10957

MEK inhibitor

Adooq's U0126-EtOH has been cited by 5 publications

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

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Grouped product items
Size	Price	Stock
5mg	$25.00	In stock
10mg	$40.00	In stock
25mg	$55.00	In stock
50mg	$70.00	In stock
100mg	$90.00	In stock
250mg	$175.00	In stock
*10mM 1mL in DMSO**	$45.00	In stock
Bulk Size	Bulk Discount

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Data Sheet

SDS

Adooq Products cited in reputable paper

Adooq's U0126-EtOH has been cited by 5 publications

Ji Wang, .et al. , Acta Pharmacol Sin, 2024, Nov 20 PMID: 39567750

Hanna Galganska, .et al. , Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187

Paul Mark Medina, .et al. , Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682

Byungki Jang, .et al. , Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055

Choe YJ, .et al. , Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Biological Activity

Discription

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

Targets

Target	Value

Product Information

Catalog Num	A10957
Formula	C18H16N6S2.C2H6O
Molecular Weight	426.6
CAS Number	1173097-76-1
SMILES	CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 77 mg/mL (180.51 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween 80+50%H2O	4.03 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.44 mL	117.21 mL	234.41 mL
0.5 mM	4.69 mL	23.44 mL	46.88 mL
1 mM	2.34 mL	11.72 mL	23.44 mL
5 mM	0.47 mL	2.34 mL	4.69 mL

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