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$0.00 - Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
- Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007
Biological Activity
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
Targets
| Target | Value |
|---|---|
| MEK2 | IC50: 0.06μM |
| MEK1 | IC50: 0.07μM |
| PKC | IC50: >10μM |
| CDK2 | IC50: >10μM |
| CDK4 | IC50: >10μM |
| MKK6/p38MAPK | IC50: 20μM |
| MKK3/p38MAPK | IC50: 38μM |
| ERK1/2 | IC50: >50μM |
| JNK | IC50: >100μM |
| MKK4 | IC50: >100μM |
| Abl | IC50: >100μM |
| In vitro (25°C) | DMSO | Warmed: 77 mg/mL (180.51 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5%DMSO+40%PEG300+5%Tween 80+50%H2O | 4.03 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.44 mL | 117.21 mL | 234.41 mL |
| 0.5 mM | 4.69 mL | 23.44 mL | 46.88 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.44 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10957 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1173097-76-1 |
| Formula | C18H16N6S2.C2H6O |
| M. Wt | 426.6 |
| Purity | >98% |
| SMILES | CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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