U0126-EtOH

Name: U0126-EtOH
Brand: Adooq Bioscience
SKU: A10957
Rating: 100 (4 reviews)

Catalog No.: A10957

MEK inhibitor

Product Citations (4)

U0126-EtOH Chemical Structure

CAS NO. 1173097-76-1

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

Availability: In stock

Package	Price	Qty
25 mg	$60.00
50 mg	$80.00
100 mg	$110.00
250 mg	$180.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq U0126-EtOH

Hanna Galganska, .et al. Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors, Cell Mol Life Sci, 2021, Dec;78(24):8229-8242 PMID: 34741187
Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Choe YJ, .et al. Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53., Int J Oncol., 2014, 44(3):761-8. PMID: 24366007

Biological Activity

U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.

Targets

Target	Value
MEK2	IC50: 0.06μM
MEK1	IC50: 0.07μM
PKC	IC50: >10μM
CDK2	IC50: >10μM
CDK4	IC50: >10μM
MKK6/p38MAPK	IC50: 20μM
MKK3/p38MAPK	IC50: 38μM
ERK1/2	IC50: >50μM
JNK	IC50: >100μM
MKK4	IC50: >100μM
Abl	IC50: >100μM

Solubility *

In vitro (25°C)	DMSO	Warmed: 77 mg/mL (180.51 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+40%PEG300+5%Tween 80+50%H2O	4.03 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.44 mL	117.21 mL	234.41 mL
0.5 mM	4.69 mL	23.44 mL	46.88 mL
1 mM	2.34 mL	11.72 mL	23.44 mL
5 mM	0.47 mL	2.34 mL	4.69 mL

*The above data is based on the productmolecular weight 426.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10957
Actions	Inhibitor
CAS No.	1173097-76-1
Formula	C18H16N6S2.C2H6O
M. Wt	426.6
Purity	>98%
SMILES	CCO.C1=CC=C(C(=C1)N)S/C(=C(/C(=C(/SC2=CC=CC=C2N)\N)/C#N)\C#N)/N
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.