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Biological Activity
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.93 mL | 94.64 mL | 189.29 mL |
| 0.5 mM | 3.79 mL | 18.93 mL | 37.86 mL |
| 1 mM | 1.89 mL | 9.46 mL | 18.93 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.79 mL |
*The above data is based on the productmolecular weight 528.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21789 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1281681-33-1 |
| Formula | C20H24Br2N4OS |
| M. Wt | 528.3 |
| Purity | >98% |
| SMILES | [H]Br.[H]Br.N1(CC/N=C2N=C(C3=CC=CC=C3)N(C4=CC=CC=C4)S/2)CCOCC1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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