VSLRGDTRG is a synthetic peptide derived from cadherin 17 (CDH17) that functions as a ligand for the α2β1 integrin. This peptide promotes the conformational activation of β1 integrin via the RGD motif, leading to enhanced cell adhesion and increased phosphorylation of FAK and ERK1/2. VSLRGDTRG is applicable in cancer research, specifically in studies involving tumors expressing CDH17, including colon and pancreatic cancers, where it may aid in understanding mechanisms of tumor proliferation and metastasis.
VSLRGDTRG is a synthetic peptide derived from cadherin 17 (CDH17) that functions as a ligand for the α2β1 integrin. This peptide promotes the conformational activation of β1 integrin via the RGD motif, leading to enhanced cell adhesion and increased phosphorylation of FAK and ERK1/2. VSLRGDTRG is applicable in cancer research, specifically in studies involving tumors expressing CDH17, including colon and pancreatic cancers, where it may aid in understanding mechanisms of tumor proliferation and metastasis.
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