Catalog No.: A13502

Cathepsin S inhibitor


Z-FL-COCHO Chemical Structure

CAS NO. N/A (Not Available)

Z-FL-COCHO is a novel Cathepsin S inhibitor.

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  • Fu R, .et al. Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjogren's syndrome murine model, Sci Rep, 2020, Jan 29;10(1):1455 PMID: 31996771
  • Klinngam W, .et al. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sj?gren's Syndrome, Sci Rep, 2019, Jul 2;9(1):9559 PMID: 31267034
  • Chen CY, .et al. Omega-3 polyunsaturated fatty acids reduce preterm labor by inhibiting trophoblast cathepsin S and inflammasome activation, Clin Sci (Lond), 2018, Oct 29;132(20):2221-2239 PMID: 30287519

Biological Activity

Z-FL-COCHO is a novel Cathepsin S inhibitor.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.6 mL 112.99 mL 225.99 mL
0.5 mM 4.52 mL 22.6 mL 45.2 mL
1 mM 2.26 mL 11.3 mL 22.6 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13502
Actions Inhibitor
CAS No. N/A (Not Available)
Formula C24H30N2O6
M. Wt 442.5
Solubility DMSO
Purity >98%
Synonyms Cathepsin S inhibitor
SMILES CNC(=O)O[[email protected]]1COC2=C([[email protected]@H]1NC(=O)C3=CC=C(C=C3)F)C=C(C=C2)N4CCN(CC4)C5COC5

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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