INCB018424 (Ruxolitinib)

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;
Grouped product items
Product Name Price Stock Qty
INCB018424 5mg
$60.00
In stock
INCB018424 10mg
$70.00
In stock
INCB018424 25mg
$90.00
In stock
INCB018424 100mg
$160.00
In stock
INCB018424 (Ruxolitinib) 10mM * 1mL in DMSO
$60.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Adooq's INCB018424 (Ruxolitinib) has been cited by 6 publications
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
  • Rasmus Siersbek, .et al. , Cancer cell, 2020, Jul 6;S1535-6108(20)30311-1 PMID: 32679107
  • Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
  • Kagoya Y, .et al. , Blood., 2014, Nov 6;124(19):2996-3006 PMID: 25217696
  • Biological Activity
    Discription INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;
    Targets
    Target Value
    Product Information
    Catalog Num A11041
    Formula C17H18N6
    Molecular Weight 306.4
    CAS Number 941678-49-5
    SMILES C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
    Synonyms Ruxolitinib, INCB18424
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 59 mg/mL (192.57 mM)
    Water Insoluble
    Ethanol 59 mg/mL (192.57 mM)
    In vivo 2% DMSO+30% PEG 300+ddH2O 4 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 32.64 mL 163.19 mL 326.37 mL
    0.5 mM 6.53 mL 32.64 mL 65.27 mL
    1 mM 3.26 mL 16.32 mL 32.64 mL
    5 mM 0.65 mL 3.26 mL 6.53 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

    • Mass

      Concentration

      Volume

      Molecular Weight

    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

    • C1

      V1

      C2

      V2

    • Calculator Reset
    Keywords: buy INCB018424 (Ruxolitinib) | INCB018424 (Ruxolitinib) Supplier | purchase INCB018424 (Ruxolitinib) | INCB018424 (Ruxolitinib) cost | INCB018424 (Ruxolitinib) manufacturer | order INCB018424 (Ruxolitinib) | INCB018424 (Ruxolitinib) distributor | buy 941678-49-5 | 941678-49-5 Supplier | purchase 941678-49-5 | 941678-49-5 cost | 941678-49-5 manufacturer | order 941678-49-5 | 941678-49-5 distributor