S-Ruxolitinib

Catalog No.: A14955

JAK inhibitor

S-Ruxolitinib

S-Ruxolitinib Chemical Structure

CAS NO. 941685-37-6

S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.

Availability: In stock

Package Price Qty
5 mg
$130.00
10 mg
$200.00
50 mg
$550.00
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Biological Activity

S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.
Targets
Target Value
JAK2IC50: 2.8nM
JAK1IC50: 3.3nM
TYK2IC50: 19nM
JAK3IC50: 428nM
Chk2IC50: >1μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 59 mg/mL (192.57 mM)
Water 5 mg/mL (16.32 mM)
Ethanol 59 mg/mL (192.57 mM)
In vivo 0.5% CMC+0.25% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.64 mL 163.2 mL 326.4 mL
0.5 mM 6.53 mL 32.64 mL 65.28 mL
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL

*The above data is based on the productmolecular weight 306.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14955
Actions Inhibitor
CAS No. 941685-37-6
Formula C17H18N6
M. Wt 306.37
Purity >98%
Synonyms INCB018424
SMILES C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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