S-Ruxolitinib

Catalog No.: A14955

JAK inhibitor

S-Ruxolitinib

S-Ruxolitinib Chemical Structure

CAS NO. 941685-37-6

S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.

Availability: In stock

Package Price Qty
5 mg
$130.00
10 mg
$200.00
50 mg
$550.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.
Targets
Target Value
JAK2IC50: 2.8nM
JAK1IC50: 3.3nM
TYK2IC50: 19nM
JAK3IC50: 428nM
Chk2IC50: >1μM
c-MetIC50: >10μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.64 mL 163.2 mL 326.4 mL
0.5 mM 6.53 mL 32.64 mL 65.28 mL
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL

*The above data is based on the productmolecular weight 306.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A14955
Actions Inhibitor
M. Wt 306.37
Formula C17H18N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 941685-37-6
Synonyms INCB018424
SMILES C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

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