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S-Ruxolitinib

JAK inhibitor

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Catalog No. A14955

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
S-Ruxolitinib 5mg A14955-5

Regular Price: $130.00

Special Price: $104.00

S-Ruxolitinib 10mg A14955-10

Regular Price: $200.00

Special Price: $160.00

S-Ruxolitinib 50mg A14955-50

Regular Price: $550.00

Special Price: $440.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.

S-Ruxolitinib

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Chemical Information

Catalog Num A14955
Actions Inhibitor
M. Wt 306.37
Formula C17H18N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 941685-37-6
Synonyms INCB018424
SMILES code C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Chemical Name (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

Biological Activity

Description
S-Ruxolitinib is the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor.
Targets
Target Value
JAK2IC50: 2.8nM
JAK1IC50: 3.3nM
TYK2IC50: 19nM
JAK3IC50: 428nM
Chk2IC50: >1μM
c-MetIC50: >10μM

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