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INCB018424 (Ruxolitinib)

INCB018424 (Ruxolitinib)

Name: INCB018424 (Ruxolitinib)
SKU: A11041

Catalog No.: A11041

JAK1/2 Inhibitor

Product Citations (3)

INCB018424 (Ruxolitinib) Chemical Structure

CAS NO. 941678-49-5

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $60.00 Special Price $48.00
10 mg	Regular Price: $70.00 Special Price $56.00
25 mg	Regular Price: $90.00 Special Price $72.00
100 mg	Regular Price: $160.00 Special Price $128.00
10mM * 1mL in DMSO	$60.00

Price Match Request

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Nature 2017
551, 247-250

Science
2017; 356(6336)

Nat Chem Biol.
1, 713–720 (2015)

Nat Commun
2016; 7: 11051.

Nat Cell Biol. 2013
15(12):1473-85.

Cell 2014 Feb 27
156(5):986-1001.

Nat Commun
2015; 6: 7139.

PNAS 2014
111(43) 15514-15519

PNAS 2014
111(23) E2404-E2413

J Neurosci. 2015
35(5): 2101–2111

Scientific Reports
5, 12298.

Cell Research
225, 707–725.

Oncogene
2014, 1–14 .

Details

Biological Activity

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

Solubility *

In vitro	DMSO	61 mg/mL (199.1 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	<1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.64 mL	163.19 mL	326.37 mL
0.5 mM	6.53 mL	32.64 mL	65.27 mL
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL

*The above data is based on the productmolecular weight 306.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Technical Details

Catalog Num	A11041
Actions	Inhibitor
M. Wt	306.4
Formula	C17H18N6
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	941678-49-5
Synonyms	Ruxolitinib, INCB18424
SMILES	C1CCC(C1)[[email protected]@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3