INCB018424 (Ruxolitinib)

Name: INCB018424 (Ruxolitinib)
Brand: Adooq Bioscience
SKU: A11041
Rating: 5 (7 reviews)

Catalog No.: A11041

JAK1/2 Inhibitor

Adooq's INCB018424 (Ruxolitinib) has been cited by 7 publications

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

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INCB018424 (Ruxolitinib) 941678-49-5 JAK1/2 Inhibitor

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Grouped product items
Size	Price	Stock
5mg	$45.00	In stock
10mg	$60.00	In stock
25mg	$85.00	In stock
50mg	$110.00	In stock
100mg	$150.00	In stock
200mg	$250.00	In stock
500mg	$430.00	In stock
*10mM 1mL in DMSO**	$50.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

Other Forms of INCB018424 (Ruxolitinib)

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Adooq Products cited in reputable paper

Adooq's INCB018424 (Ruxolitinib) has been cited by 7 publications

Meenu Kesarwani, .et al. , Blood Adv, 2024, Jun 11;8(11):2765-2776 PMID: 38531054
Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154
Rasmus Siersbek, .et al. , Cancer cell, 2020, Jul 6;S1535-6108(20)30311-1 PMID: 32679107
Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277
Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Kagoya Y, .et al. , Blood., 2014, Nov 6;124(19):2996-3006 PMID: 25217696

Biological Activity

Description

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A11041
Formula	C17H18N6
Molecular Weight	306.4
CAS Number	941678-49-5
SMILES	C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Synonyms	Ruxolitinib, INCB18424
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	59 mg/mL (192.57 mM)
	Water	Insoluble
	Ethanol	59 mg/mL (192.57 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.64 mL	163.19 mL	326.37 mL
0.5 mM	6.53 mL	32.64 mL	65.27 mL
1 mM	3.26 mL	16.32 mL	32.64 mL
5 mM	0.65 mL	3.26 mL	6.53 mL

Useful Calculator

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂