INCB018424 (Ruxolitinib)

Catalog No.: A11041

JAK1/2 Inhibitor

INCB018424 (Ruxolitinib)

INCB018424 (Ruxolitinib) Chemical Structure

CAS NO. 941678-49-5

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $90.00

Special Price $72.00

100 mg

Regular Price: $160.00

Special Price $128.00

10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

INCB018424 is a potent and selective inhibitor of Janus-associated kinase (JAK) 1 and 2, with IC50 to be 2.7, 4.5 and 332 nM for JAK1, JAK2 and JAK3 respectively;
In vitro DMSO 61 mg/mL (199.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.64 mL 163.19 mL 326.37 mL
0.5 mM 6.53 mL 32.64 mL 65.27 mL
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL

*The above data is based on the productmolecular weight 306.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11041
Actions Inhibitor
M. Wt 306.4
Formula C17H18N6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 941678-49-5
Synonyms Ruxolitinib, INCB18424
SMILES C1CCC(C1)[[email protected]@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

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