Catalog No.
Product Name
Application
Product Information
Citations
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Opioid Receptor Antagonist
TIPP is a highly selective δ-opioid receptor antagonist, exhibiting a Ki value of 1.22 nM. It effectively blocks δ-opioid receptor activity, making it a valuable tool for studying opioid signaling pathways and the effects of opioid modulation in various physiological contexts. Its unique properties facilitate research into pain management, addiction, and potential therapeutic interventions targeting the opioid system. -
Opioid Receptor Agonist
Dermorphin Analog is a synthetic heptapeptide that serves as a potent μ-opioid receptor agonist. This compound demonstrates significant analgesic activity through its high affinity for opioid receptors, making it a valuable tool for studying pain mechanisms and opioid signaling pathways. Researchers may utilize Dermorphin Analog in investigations of pain management therapies and the development of novel analgesics. -
Opioid Agonist
β-Lipotropin (60-65) is an opioid peptide that functions as a potent opioid agonist. It is known to interact with the opioid receptors, influencing pain modulation and various neurobiological processes. This reagent is valuable for research applications focused on opioid signaling pathways, pain management studies, and the exploration of its physiological roles in the body. -
δ-receptor Agonist
DSLET ([D-Ser2, Leu5, Thr6]-enkephalin) is a selective agonist of the delta-opioid receptor. This enkephalin-derived peptide exhibits high specificity for δ-receptor binding, making it a valuable tool for studying opioid signaling pathways. Its distinct activity profile supports research into pain modulation, addiction, and potential therapeutic applications in neurobiology. -
MOR Agonist
MOR agonist-5 is a selective and potent mu-opioid receptor (MOR) agonist, exhibiting an EC50 of 0.25 nM. It demonstrates a significantly lower affinity for delta-opioid receptors (DOR) with an EC50 of 10 nM, and a negligible effect on kappa-opioid receptors (KOR) and nociceptin/orphanin FQ peptide receptors (NOR) at concentrations exceeding 10,000 nM. MOR agonist-5 displays substantial antinociceptive properties, making it a valuable tool for research into pain management and opioid receptor pharmacology. -
Opioid Peptide
β-Casomorphin is an opioid peptide that primarily acts as an agonist at opioid receptors. This compound exhibits biological activity associated with pain modulation, gastrointestinal function, and is relevant in studies of addiction and opioid signaling pathways. β-Casomorphin serves as a valuable tool in pharmacological research to understand the implications of opioid peptides in various physiological processes. -
Analgesics
Azo-enkephalin is an endorphin analog that acts primarily on opioid receptors, exhibiting significant analgesic activity. This compound is utilized in the development of novel opioid analgesics, providing insight into pain modulation and therapeutic options in pain management research. Azo-enkephalin serves as a valuable tool for exploring the role of endorphins in analgesia and for studying opioid receptor interactions. -
KOR Agonist
Ketazocine is a selective κ-opioid receptor (KOR) agonist, playing a crucial role in modulating pain and sedation pathways. This compound exhibits significant analgesic and sedative properties, making it a valuable tool for research in pain management and the development of new therapeutic agents targeting the KOR. Its ability to influence opioid receptor activity can contribute to understanding KOR-related physiological processes and potential treatment strategies for pain-related disorders. -
κ-Opioid Receptor Agonist
ICI-199441 is a potent and selective κ-opioid receptor agonist, primarily involved in mediating analgesic effects. This compound has demonstrated the ability to enhance cardiac resilience in models of ischemia/reperfusion, making it a valuable tool for investigating pain modulation and cardiovascular protection. Its specificity for the κ-opioid receptor supports targeted research in pain management and heart disease. -
MOR Inhibitor
MOR agonist-1 is a selective μ-opioid receptor (MOR) agonist known for its pronounced analgesic activity. This compound is valuable for research focused on pain modulation and the exploration of pain-related disorders. Its mechanism of action makes it an essential tool for studies investigating opioid pharmacology and therapeutic interventions in pain management. -
Opioid Receptor
3,4-Difluoro-N,N-didesmethyl U-47700 TFA is a synthetic opioid compound that selectively targets opioid receptors. It exhibits potent analgesic activity, making it valuable for research into pain management and opioid receptor modulation. This compound can be utilized in studies exploring receptor binding affinity, signaling pathways, and drug formulation in opioid research. -
KOR Agonist
FEKAP is a selective kappa opioid receptor (KOR) agonist with a Ki value of 0.43 nM, demonstrating effective brain penetration. The isotope-labeled form, 11C-FEKAP, is suitable for use as a radiotracer in imaging studies targeting KOR. This compound is valuable for research applications exploring pain modulation, addiction mechanisms, and neuropharmacology. -
Opioid Receptor
2-(Di-sec-butylamino)-1-(1-(2-fluorobenzyl)-1H-pyrrol-2-yl)ethan-1-ol functions as a selective ligand for opioid receptors. This compound exhibits significant affinity and activity, making it valuable for studies on pain management and analgesic pathways. Its structural similarities to known opioids allow for exploration of the receptor interactions and potential therapeutic applications in opioid research. -
AH 7921 Metabolite
N,N-didesmethyl AH 7921 is a metabolite of the synthetic opioid AH 7921, functioning primarily as a μ-opioid receptor agonist. This compound exhibits key biological activity related to pain modulation and is utilized in research focusing on opioid metabolism and pharmacodynamics. Its analysis can contribute to understanding the metabolism and effects of opioid substances in various biological systems. -
κ-opioid agonists
ICI-204448 free acid is a potent κ-opioid agonist that demonstrates limited central nervous system penetration. It effectively displaces the binding of the kappa-opioid ligand ^3H-bremazocine from guinea pig cerebellum membranes, making it a valuable tool for exploring κ-opioid receptor interactions. This compound is useful in research applications focused on pain modulation, neuropsychiatric disorders, and the pharmacological profiling of κ-opioid receptors. -
Opioid Receptor Modulator
Opioid Receptor Modulator 1 functions as a selective modulator of opioid receptors, primarily influencing mu and delta subtypes. This compound demonstrates significant biological activity in pain relief and modulation of reward pathways, making it a valuable tool for research into analgesics and addiction therapies. Its applications extend to studies on the pharmacological effects of opioid modulation in various neurological conditions. -
Opioid Receptor Control
Isopaynantheine is an alkaloid that primarily targets opioid receptors. It demonstrates significant antinociceptive activity, making it valuable for pain management studies. Researchers utilize Isopaynantheine to explore opioid receptor modulation and its therapeutic potential in pain-related research. -
Oxycodone Metabolite
Nor-6α-Oxycodol is a metabolite of Oxycodone, classified under opioids. This compound demonstrates biological activity relevant to pain modulation and opioid receptor interaction. It serves as an important analytical tool for research focused on opioid metabolism and pharmacokinetics, providing insights into opioid effects and potential therapeutic applications. -
Opioid Receptor agonist
DuP 747 is a selective agonist of the kappa-opioid receptor. It exhibits analgesic properties, making it a valuable compound for research focused on pain management and opioid receptor pharmacology. This reagent is useful in exploring the physiological and therapeutic roles of kappa-opioid receptors in various biological contexts. -
NOP Agonist
SCH 486757 is a selective nociceptin/orphanin FQ peptide (NOP) receptor agonist. This compound exhibits significant biological activity in modulating pain responses and has been utilized in research studies focusing on cough mechanisms. Its oral bioavailability allows for convenient administration in preclinical models for investigating the therapeutic potential of NOP receptor modulation. -
kappa-opioid receptor Agonist
22-Thiocyanatosalvinorin A is a potent and selective kappa-opioid receptor agonist, exhibiting an EC50 of 0.077 nM. This compound demonstrates significant biological activity through its interaction with the kappa-opioid receptor, facilitating applications in pain management and neuropharmacological research. Its specificity makes it a valuable tool for studying kappa-opioid receptor signaling pathways and potential therapeutic effects in various neurological conditions. -
Opioid Receptor Agonist
7-PET is a potent μ-opioid receptor agonist, demonstrating significant efficacy in activating opioid signaling pathways. This compound is primarily utilized in research focused on psychiatric disorders, aiding in the exploration of pain modulation, addiction mechanisms, and potential therapeutic interventions for mood disorders. Its selective action makes it a valuable tool for understanding the complex roles of opioid receptors in the central nervous system. -
Opioid Receptor Antagonist
Naltrindole 5′-isothiocyanate (5'-NTII) is an opioid receptor antagonist with a primary mechanism of non-selective antagonism at delta opioid receptors. This compound effectively inhibits the analgesic effects produced by DSLET, while leaving the analgesic effects mediated by DPDPE unaffected. Naltrindole 5′-isothiocyanate is valuable in research applications focused on understanding the therapeutic potential and mechanisms of opioid receptor modulation. -
Opioid Compound
Bromadoline is a utopioid that primarily targets opioid receptors, exhibiting significant antinociceptive activity in rodent models. This compound is utilized in research to explore pain management mechanisms and the development of novel analgesics. Its specific receptor interactions make it a valuable tool for studying the pharmacological effects of opioids in various biological systems. -
Opioid Receptor
Volazocine is an opioid benzomorphane derivative that selectively targets opioid receptors. This compound exhibits significant analgesic activity, making it a valuable research tool for studying pain mechanisms and opioid pharmacology. It is particularly useful in evaluating the efficacy and safety profiles of new analgesic therapies. -
Opioid Receptor
1-(5-Fluoropentyl)-1H-indazole-3-carboxylic acid is a selective modulator of opioid receptors. This compound exhibits significant affinity for cannabinoid receptor sites and shows potential in studying the therapeutic effects of cannabinoid modulation. It is primarily used in research exploring the pharmacological effects of synthetic cannabinoids and their metabolites. -
Opioid Antagonist
RX809055AX is a potent long-acting opioid antagonist that demonstrates selectivity towards mu and delta opioid receptors. This compound effectively inhibits opioid-induced signaling, making it valuable for research applications in pain management and addiction studies. Its extended duration of action offers a consistent approach to investigating opioid receptor activity and its physiological implications. -
Opioid Receptor
Piperidylthiambutene hydrochloride is an opioid receptor agonist that exhibits significant analgesic activity in various animal models. This compound is primarily utilized in research focused on pain management and the study of opioid receptor signaling pathways. Its utility in pharmacological studies makes it a valuable reagent for investigating opioid-related mechanisms and potential therapeutic applications. -
δ-Opioid Receptor Agonist
AZ 12488024 is a potent δ-opioid receptor agonist that acts as a derivative of SNC80. This compound exhibits significant biological activity related to mood regulation and is primarily utilized in research focused on major depressive disorder. Its specific mechanism of action at the δ-opioid receptor makes it a valuable tool for studying opioid-related pathways and their implications in neuropsychiatric conditions. -
κ-Opioid Receptor Agonist
R-84760 is a selective κ-opioid receptor agonist that exhibits significant antinociceptive effects. This compound is primarily utilized in pain research, offering insights into the modulation of pain pathways and potential therapeutic applications in analgesia. Its specificity for the κ-opioid receptor makes it a valuable tool for understanding opioid receptor pharmacology and the development of new pain management strategies. -
Opioid Compound
N-Phenethylnoroxymorphone is an opioid compound that acts primarily on the μ-opioid receptor, enhancing the analgesic effects of morphine. This compound has demonstrated increased morphine-induced analgesia in preclinical models, particularly in rats. Its potent efficacy makes it suitable for research applications in the study of pain mechanisms and neurological disorders. -
Propoxyphene Metabolite
(+)-Norpropoxyphene maleate is an opioid metabolite derived from Propoxyphene. This compound is primarily used in research to study the pharmacokinetics and pharmacodynamics of opioid metabolites. Its biological activity has been investigated in relation to pain management and the opioid signaling pathway, contributing to the understanding of opioid receptor interactions and potential therapeutic implications. -
NOP Agonist
AT-035 is a high-affinity and selective agonist of the nociceptin/orphanin FQ peptide (NOP) receptor. It demonstrates significant biological activity in modulating pain pathways and has potential applications in the study of nociceptive signaling and related disorders. AT-035 offers valuable insights into the therapeutic potential of NOP receptor modulation in various research settings. -
Opioid Compound
Dipyanone hydrochloride is an opioid compound that interacts with the mu-opioid receptor, leading to analgesic effects. This reagent is primarily used in research related to pain management and opioid receptor studies. Its structural similarity to other opioids makes it a valuable tool for investigating opioid mechanisms and exploring potential therapeutic applications. -
μ-Opioid Receptor Agonist
U-48520 is a μ-opioid receptor agonist, demonstrating an EC50 value of 1561 nM. This compound is primarily utilized in research applications focused on pain management and opioid signaling pathways. Its activity at the μ-opioid receptor underscores its potential for studying analgesic effects and receptor pharmacodynamics in cellular and in vivo models. -
Opioid Receptor Antagonist
JTC-801 free base is a selective antagonist of the opioid receptor-like 1 (ORL1) receptor, exhibiting a binding affinity with a Ki value of 8.2 nM. This compound effectively modulates ORL1 receptor signaling, making it a valuable tool for research into pain modulation and opioid receptor pharmacology. Its application extends toward studying the role of ORL1 in various physiological and pathological processes. -
Opioid Compound
Bromadol is a synthetic opioid that acts as a potent agonist at the mu-opioid receptor. It exhibits significant analgesic properties, making it valuable for pain research and pharmacological studies. Bromadol's unique chemical structure offers potential insights into opioid receptor mechanisms and the development of novel analgesics. -
KOPr Agonist
Salvinorin A propionate is a potent kappa-opioid receptor (KOPr) agonist, exhibiting a Ki value of 4.3 nM. This non-nitrogenous neoclerodane, derived from Salvia divinorum, demonstrates high efficacy in receptor activation. Salvinorin A propionate is utilized in investigations of opioid signaling pathways and is of particular interest in studies related to pain management and neuropharmacology. -
Opioid Compounds
AH 7563 is an opioid compound that demonstrates significant analgesic properties. In in vivo assays, it exhibited an ED50 of 15.3 mg/kg when administered orally and 15.5 mg/kg via subcutaneous injection, as measured in the phenylquinone and hot plate tests in mice. This compound is suitable for research applications focusing on pain management and opioid receptor studies. -
Opioid Compound
N-(1-Phenethyl-4-piperidyl)-N-phenethylpropanamide hydrochloride is an opioid compound that acts primarily on the opioid receptors in the central nervous system. This compound demonstrates significant analgesic properties and is useful in studies exploring pain relief mechanisms. It is applicable in research focusing on opioid receptor modulation and the development of new therapeutic agents for pain management. -
NOP Receptor Agonist
AT-127 is a partial agonist of the nociceptin/orphanin FQ peptide (NOP) receptor, promoting NOP/G-protein interactions in a concentration-dependent manner. Its biological activity indicates potential applications in pain modulation and neuropharmacology research. This compound serves as a valuable tool for investigating the role of NOP receptors in various physiological and pathological processes. -
Opioid Compound
3,4-Ethylenedioxy U-51754 hydrochloride is an opioid compound that acts primarily on the opioid receptors in the central nervous system. It exhibits analgesic properties and is utilized in research focused on pain modulation and the development of new analgesics. This reagent is essential for studies investigating the structure-activity relationships of opioid analogs and their potential therapeutic effects. -
κ-opioid receptor Antagonist
5′-Guanidinonaltrindole is a selective antagonist of the κ-opioid receptor, inhibiting its activation. This compound plays a crucial role in research related to pain modulation, stress response, and addiction mechanisms. It is instrumental in studying the physiological effects and potential therapeutic applications of kappa opioid receptor modulation in various biological systems. -
Analgesics
Tramadol N-oxide is a derivative of tramadol that primarily targets analgesic pathways. It produces dose-dependent, long-lasting antinociception through its affinity for the μ-opioid receptor (Ki = 38.5 μM) while exhibiting weaker interactions with δ and κ receptors (Ki > 100 μM). This compound is valuable for research into analgesic effects and the mechanisms underlying pain relief. -
Opioid Compound
3,4-Difluoro-N-desmethyl U-47700 hydrochloride is an opioid compound that acts on the μ-opioid receptor, demonstrating potent analgesic properties. This reagent is primarily utilized in research focused on pain management and addiction studies, contributing to a deeper understanding of opioid receptor activities and their therapeutic implications. Its unique fluorinated structure enhances its pharmacological profile, making it a valuable tool for scientific investigations into opioid-related pathways. -
Opioid Analog
Chlorphine is a halogenated opioid analog that primarily targets opioid receptors in the central nervous system. This compound exhibits significant neuroactive properties, making it valuable for studying pain modulation and addiction mechanisms. Its unique structure allows for exploration of receptor interactions and the development of potential therapeutic agents in pain management and opioid research. -
Opioid Receptor
3,4-Difluoro U-49900 hydrochloride is a selective opioid receptor agonist, primarily targeting the mu-opioid receptor. This compound exhibits strong analgesic properties and is utilized in research to investigate opioid signaling pathways and pain management mechanisms. Its potential applications include studies on addiction, analgesia, and opioid receptor pharmacology. -
Opioid Compound
Desmethylmoramide is an opioid compound that exerts its effects primarily through interaction with opioid receptors, facilitating pain relief. This compound demonstrates notable analgesic activity in rodent models, making it a valuable tool for research into pain management and opioid pharmacology. Its structural similarity to established opioids may provide insights into opioid receptor function and the development of new analgesic therapies. -
mu-Opiate Receptor Ligand
CHIR 4531 is a trimer peptide that functions as a mu-opiate receptor ligand, exhibiting a binding affinity characterized by a Ki value of 6 nM. This compound is primarily utilized in research focused on pain management, addiction, and opioid signaling pathways. Its ability to selectively engage the mu-opiate receptor makes it a valuable tool for studying the biological effects of opiates in various experimental contexts. -
Opioid Receptor
DuP 747 hydrochloride is a selective agonist of the kappa-opioid receptor, primarily involved in analgesic activity. Studies indicate its administration can yield variable responses, with a lesser agonistic profile when given subcutaneously compared to intraperitoneal or oral routes. Notably, the 5-hydroxy-desmethoxy metabolite of DuP 747 predominantly influences behaviors associated with the saline-appropriate lever. These findings highlight the potential role of its metabolites in mediating responses similar to other kappa-opioid receptor ligands, enabling further exploration in the field of pain management and receptor pharmacology.
