Catalog No.
Product Name
Application
Product Information
Citations
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SMO Inhibitor
AZD7254 is an orally active Smoothened (SMO) inhibitor with a reported EC50 of 1.0 nM against Sonic Hedgehog (Shh) protein. This compound effectively modulates hedgehog signaling pathways, making it a valuable tool for investigating the role of SMO in various cancers and developmental disorders. Its potent inhibition of SMO activity supports research applications in targeted therapies and pathway analysis. -
Smo Antagonist
MRT-14 is a potent Smoothened (Smo) antagonist, specifically targeting the Hedgehog (Hh) signaling pathway. By inhibiting Smo, MRT-14 disrupts the signal transduction linked to Hh morphogens. This compound demonstrates potential for research applications in various cancers associated with dysregulated Hh signaling. -
Smo Agonist
(Rac)-SAG is a potent agonist of the Smoothened (Smo) receptor, exhibiting an EC50 of 3 nM and a Kd of 59 nM. This compound activates the Hedgehog signaling pathway, making it an invaluable tool in studies focused on Smo-mediated processes. Additionally, (Rac)-SAG can counteract the inhibition of Smo by Cyclopamine, facilitating research into signaling and developmental biology. -
SMO Inhibitor
SMO-IN-1 is an orally active Smoothened (SMO) inhibitor that demonstrates an EC50 of 89 nM for sonic hedgehog (Shh) protein. This compound is effective in disrupting the hedgehog signaling pathway, making it a valuable tool in cancer research and developmental biology studies. It may be particularly relevant for investigating tumors associated with aberrant hedgehog signaling. -
Smoothened Antagonist
SMO-IN-4 is a potent oral antagonist of the Smoothened (SMO) protein, displaying an IC50 of 24 nM. This compound demonstrates significant antitumor activity and is utilized in research focused on hedgehog signaling pathways and cancer therapy. SMO-IN-4 serves as a valuable tool for investigating SMO-related mechanisms in various malignancies. -
Smo Antagonist
PF-5274857 hydrochloride is a potent, selective antagonist of Smoothened (Smo) with an IC50 of 5.8 nM and a Ki of 4.6 nM. Its oral bioavailability and ability to penetrate the blood-brain barrier enhance its utility in research on tumors, particularly brain tumors and brain metastases associated with an activated Hedgehog (Hh) signaling pathway. This compound is valuable for studies aimed at understanding Smo-mediated tumorigenesis and developing targeted therapeutics. -
Smo Activator
7-keto-25-Hydroxycholesterol is an oxysterol that acts as an activator of Smoothened (Smo). This compound interacts specifically with the extracellular cysteine-rich domain (CRD) of Smo, facilitating its activation. Research applications include studies on hedgehog signaling pathways and the exploration of Smo’s role in developmental biology and cancer. -
Smo Inhibitor
Saridegib hydrochloride is a selective inhibitor of Smoothened (Smo), a critical component of the Hedgehog (Hh) signaling pathway. By targeting Smo, this compound effectively disrupts Hh-mediated signaling, which is implicated in various developmental processes and diseases, including cancer. It is utilized in research to explore the role of the Hh pathway in tumorigenesis and as a potential therapeutic approach in Smo-dependent malignancies. -
ARα2c Inhibitor
BAY-2925976 is an α2C adrenergic receptor (ARα2C) inhibitor that selectively blocks receptor activity. This compound is primarily utilized in research related to obstructive sleep apnea (OSA), providing insights into its underlying mechanisms and potential therapeutic approaches. BAY-2925976 aids in elucidating the role of ARα2C in respiratory regulation and sleep disorders. -
β-AR Antagonist
Lubabegron fumarate is a selectiveβ-adrenergic receptor (β-AR) modulator, exhibiting antagonistic properties at both β1 and β2 receptor subtypes while acting as an agonist at the β3 subtype in bovine species. This compound effectively reduces ammonia (NH3) gas emissions from livestock and their waste, making it a valuable tool for improving environmental sustainability in agricultural practices. Lubabegron fumarate is primarily used in research applications focused on animal health and emissions management. -
PGF2α Analog
Fenprostalene is a potent analog of prostaglandin F2α (PGF2α) that primarily targets the prostaglandin pathway. This compound is effective in veterinary medicine for inducing corpus luteum regression and lowering blood progesterone levels in dogs. Its primary applications include the treatment of pyometra and the induction of abortion, making it a critical reagent in reproductive health studies and veterinary practices. -
Amino Acid Derivatives
H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative featuring an Fmoc protecting group. This compound serves as a key intermediate for the synthesis of diacylated GLP-1 derivatives, which possess antidiabetic properties. Its utility in peptide synthesis makes it an important reagent in chemical biology and drug development. -
Amino Acid Derivatives
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is a protected form of the amino acid leucine, featuring a Boc protecting group. It serves as a useful intermediate in peptide synthesis, particularly for the generation of L-prolyl-L-leucyl-glycinamide, a peptide mimetic known for its modulatory effects on dopamine receptors. This compound is valuable in research focused on neuropharmacology and peptide therapeutics. -
PAF Analog
2-Thio-PAF is a synthetic analog of platelet-activating factor (PAF) that serves as a valuable tool for studying PAF metabolism. It effectively inhibits PAF acetylhydrolases, allowing researchers to assess enzyme activity through colorimetric assays. This compound is significant in investigating various biological processes influenced by PAF signaling, including inflammation and cellular responses. -
Biochemical Assay Reagent
Pinolenic acid ethyl ester is a derivative of pinolenic acid, a polyunsaturated fatty acid known for its lipid-regulating properties. This reagent is used in biochemical assays to study appetite regulation and lipid metabolism due to its ability to enhance satiety hormone levels such as CCK and GLP-1, contributing to appetite suppression. Research indicates that pinolenic acid can diminish arachidonic acid levels in hepatic cells, making it relevant for studies investigating cholesterol efflux and fatty acid metabolism. Its lipophilic nature allows for versatile applications in various biochemical studies targeting metabolic pathways. -
Phenethylamine
α-Ethyl 2C-D hydrochloride is a phenethylamine derivative that acts primarily on serotonin and dopamine receptors. This compound exhibits significant psychoactive properties and has been utilized in research to explore the effects of amphetamines and their analogs. It serves as a reference standard in drug discrimination studies, particularly for understanding the pharmacological profiles of MDMA. -
Lipid
C18:1 Anandamide is an endocannabinoid lipid that primarily targets cannabinoid receptors, particularly CB1 and CB2. It exhibits various biological activities, including modulation of pain, appetite, and mood. C18:1 Anandamide is widely utilized in research focused on the endocannabinoid system, neurobiology, and the therapeutic potential of cannabinoids in a range of physiological processes and disorders. -
Lipid
N-20:4 L-Serine MeEster is a lipid-derived compound that functions as a structural analog of anandamide. It exhibits significant biological activity in modulating cannabinoid receptor signaling pathways, making it a valuable reagent for studying lipid-mediated cellular processes. This compound is useful in various research applications, including investigations of endocannabinoid system dynamics and lipid signaling in neurobiology. -
Lipid
C17:0 Anandamide phosphate sodium is a lipid derivative of anandamide, primarily targeting cannabinoid receptors. This compound possesses bioactive properties that may influence various physiological pathways, making it a valuable tool in studies related to endocannabinoid signaling, lipid metabolism, and neurobiology. Its applications include investigating the role of lipid mediators in inflammation, pain, and neurodegenerative diseases. -
Antianxiety Compound
Fluprazine is an anxiolytic compound that primarily targets neurotransmitter systems to alleviate anxiety symptoms. This compound exhibits key biological activity in modulating serotonin and dopamine receptors, making it relevant in the study of various psychiatric disorders. Researchers utilize Fluprazine for investigating therapeutic approaches in anxiety and related mood disorders. -
Lipid
C20:4 Anandamide (AEA) is a bioactive lipid that acts as an endocannabinoid, primarily targeting cannabinoid receptors in the central nervous system. This compound is known for its involvement in pain modulation, appetite regulation, and neuroprotection. C20:4 AEA is commonly utilized in research to investigate the physiological effects of endocannabinoids and their potential therapeutic applications in various neurological and inflammatory conditions. -
Biochemical Assay Reagent
CGS 21680 sodium is an adenosine A2A receptor agonist that selectively activates the A2A receptor, influencing various signaling pathways. This compound exhibits biological activities such as modulation of neurotransmission and anti-inflammatory effects, making it useful in research involving neurological and cardiovascular studies. It is commonly employed in biochemical assays to explore the roles of adenosine receptors in cellular processes and their potential therapeutic applications. -
Biochemical Assay Reagent
Oleoylsulfamide is a selective inhibitor of cannabinoid receptor 1 (CB1). This compound can be utilized as a biochemical assay reagent to investigate the role of CB1 in various physiological processes. It is particularly valuable in studies related to metabolic disorders, pain modulation, and neuroprotection. -
Lipid
C17:1 Anandamide is a synthetic derivative of anandamide, a significant endocannabinoid that interacts primarily with cannabinoid receptors. This compound demonstrates key biological activities, including modulation of pain perception, appetite, and mood regulation. C17:1 Anandamide is useful for studying the endocannabinoid system and its implications in various therapeutic areas, such as neurobiology and pain management. Its unique lipid structure enables investigations into lipid signaling pathways and their role in cellular processes. -
Lipid
NBD AA is a fluorescent analog of anandamide that selectively targets cannabinoid receptors. This compound plays a critical role in lipid signaling pathways and is utilized in studies examining endocannabinoid system functions. Its fluorescent properties make NBD AA an effective tool for visualizing lipid distribution and activity in live cell imaging and various biochemical assays. -
Lipid
N-Arachidonoyl-L-Serine sodium is a lipid compound that acts as an analog of anandamide, a well-known endocannabinoid. This reagent exhibits important biological activities, including the modulation of pain sensation, inflammation, and neuroprotection. It is utilized in research exploring cannabinoid receptor pathways and their therapeutic potential in various neurological and inflammatory disorders. -
Lipid
C18:2 Anandamide phosphate sodium is a phospholipid derivative of anandamide, acting primarily on cannabinoid receptors. This compound exhibits bioactive properties that influence lipid signaling pathways and modulate neuronal communication. It is applicable in research exploring endocannabinoid system dynamics, neuroprotection, and potential therapeutic avenues for neurological disorders. -
Lipid
N-Oleoyl-L-serine sodium is an analog of anandamide that primarily targets lipid signaling pathways. This compound exhibits notable biological activity as a cannabinoid receptor modulator, influencing physiological processes such as pain perception and inflammation. It is frequently used in research applications focused on neurobiology and lipid metabolism. -
Platelet Aggregation Inhibitor
Cloricromen is a potent platelet aggregation inhibitor that functions by targeting the mechanisms involved in thrombus formation. Demonstrating efficacy in inhibiting platelet aggregation in both human subjects and experimental models, Cloricromen is a valuable reagent for research in cardiovascular disease and thrombotic disorders. Its application in studying platelet function and related pathologies makes it an essential tool for investigations in vascular biology. -
Neuroleptic Agent
Fenaperone hydrochloride is a neuroleptic agent that primarily targets dopamine receptors in the central nervous system. It exhibits antipsychotic properties, making it relevant for research in neurological disorders and psychiatric conditions. Its mechanism includes modulation of neurotransmitter activity, contributing to its potential therapeutic effects in various mental health applications. -
Biochemical Assay Reagent
1,3-Dipropyl-7-methylxanthine is a selective antagonist of adenosine receptors, primarily targeting the A1 subtype. It exhibits potent inhibitory effects on adenosine-mediated signaling pathways, making it valuable in biochemical assays for studying adenosine receptor functions. This compound is commonly utilized in research examining cellular processes influenced by adenosine, such as neurotransmission, inflammation, and metabolic regulation. -
Biochemical Assay Reagent
5'-Ethylcarboxamido-2',3'-isopropylidene adenosine is a selective agonist targeting A2B adenosine receptors. This compound enhances A2B receptor activity, making it valuable for investigating the physiological roles of adenosine signaling in various biological processes. It serves as a pertinent tool in biochemical assays and research applications aimed at understanding adenosine's effects and its potential as a therapeutic target in drug development. -
Biochemical Reagent
Nestifylline is a biochemical reagent that functions primarily as an antagonist of adenosine receptors. It exhibits significant activity in modulating airway constriction, making it a valuable tool for studying respiratory diseases, particularly bronchospasm. Researchers can utilize Nestifylline to explore mechanisms underlying airway responsiveness and potential therapies for respiratory disorders. -
Ester Product
(9Z,11E)-Octadecadien ethanolamide is an ester product that serves as a bioactive lipid mediator. It is known to modulate endocannabinoid receptor activity and influences various physiological processes, including pain perception and inflammation. This compound is primarily utilized in research focused on lipid signaling pathways, cannabinoid receptor studies, and neurobiology. -
Biochemical Assay Reagent
NBD AEA is a fluorescent derivative of anandamide (arachidonoylethanolamide) designed for use as a biochemical assay reagent. This compound serves as a valuable tool for studying cannabinoid receptors and endocannabinoid signaling pathways. It enables the visualization and quantification of AEA interactions in various biological systems, facilitating research in pharmacology and neurobiology. -
Drug Impurity
Mirabegron impurity 6 is a recognized impurity of the pharmaceutical compound Mirabegron, which primarily acts as a β3-adrenergic receptor agonist. It serves as an important reference standard for quality control in the synthesis and analysis of Mirabegron and is crucial in ensuring the purity and efficacy of the drug. This impurity can assist in research applications involving pharmacokinetics, safety assessments, and metabolic studies of β3-adrenergic modulators. -
Drug Impurity
Tamsulosin impurity 15 is a chemical impurity associated with the pharmaceutical compound Tamsulosin, which primarily targets alpha-1 adrenergic receptors. This impurity is relevant for quality control and characterization in the development and analysis of Tamsulosin formulations. Research applications include assessing the purity and safety profiles of Tamsulosin in pharmaceutical formulations. -
Drug Impurity
(S)-Tamsulosin hydrochloride is a chiral impurity associated with the pharmaceutical compound tamsulosin, primarily targeting alpha-1 adrenergic receptors. This reagent may serve a critical role in the analytical characterization and quality control of tamsulosin formulations. Its presence can impact the pharmacological profile and efficacy of the drug, making it an essential component for research and development in pharmaceutical sciences. -
Drug Impurity
Acebutolol impurity 7 is a secondary compound generated during the synthesis of Acebutolol, a selective beta-1 adrenergic receptor blocker. This reagent is primarily utilized in drug development and quality control to ensure the purity and safety of pharmaceutical formulations. Its characterization and analysis are essential for compliance with regulatory standards in chemical research and formulation studies. -
Drug Impurity
Dexmedetomidine impurity 2 is a chemical impurity related to Dexmedetomidine, a selective alpha-2 adrenergic receptor agonist. This impurity is significant in assessing the purity and quality of Dexmedetomidine formulations. It is utilized primarily in analytical chemistry and pharmaceutical development, particularly for the evaluation of drug substances and ensuring compliance with regulatory standards. -
Drug Impurity
Pramipexole impurity 1 (2-N-Propyl pramipexole) is a chemical impurity associated with the drug Pramipexole, which targets dopamine receptors. This impurity is essential for quality control and validation studies in pharmaceutical research, ensuring the purity and safety of drug formulations. It serves as a reference compound in analytical chemistry and can facilitate the investigation of drug metabolism and pharmacokinetics. -
Drug Impurity
Ropinirole impurity 2 is a chemical impurity associated with the synthesis of Ropinirole, a dopamine receptor agonist. This compound can be utilized for analytical purposes in the assessment of drug purity and quality control in pharmaceutical research. Its presence is significant for the evaluation of Ropinirole formulations and may impact the overall efficacy and safety profile of the drug. -
Drug Impurity
Alfuzosin EP impurity 1 hydrochloride, also known as 2,3,4,5-Tetradehydro alfuzosin hydrochloride, is a recognized impurity of Alfuzosin hydrochloride. This compound is essential for evaluating the purity and stability of alfuzosin formulations in pharmaceutical development. Researchers may utilize this impurity in studies assessing drug quality, pharmacokinetics, and mechanism of action related to alpha-1 adrenergic receptor antagonism. -
Adrenaline Impurity
Methoxy adrenaline hydrochloride is a synthetic analog of adrenaline, serving as a known impurity in adrenaline formulations. Its presence is critical for quality control in pharmaceutical research, allowing for the assessment of purity and stability in adrenaline products. This compound can also be utilized in various biological studies to investigate adrenergic receptor interactions and signaling pathways. -
Drug Impurity
Metoprolol Impurity 13 is a chemical impurity associated with Metoprolol, a selective beta-1 adrenergic receptor antagonist. This impurity can be utilized for analytical purposes in drug development, including stability studies and quality control assessments. Researchers can employ this compound to ensure the purity and compliance of Metoprolol formulations in pharmaceutical applications. -
Drug Impurity
Ropinirole impurity 5 is a chemical impurity associated with Ropinirole, a dopamine agonist primarily targeting the D2 and D3 dopamine receptors. This impurity is important for analytical and quality control purposes in pharmaceutical research and development. Its identification and quantification are crucial for ensuring the purity and safety of Ropinirole formulations. -
Drug Impurity
Ropinirole impurity 1 is a structural impurity derived from Ropinirole, a selective dopamine agonist primarily targeting D2 dopamine receptors. This reagent is crucial for analytical and quality control applications, serving as a reference standard for assessing the purity and quality of Ropinirole formulations. Its characterization aids in the understanding of processing variability and ensures compliance with regulatory standards in pharmaceutical development. -
Drug Intermediate Control
(Rac)-7-Methoxy propranolol is a key synthetic intermediate that plays a critical role in the production of pharmaceuticals. This compound is utilized in drug formulation and development, particularly in studies related to beta-adrenergic receptor antagonism, which is important for cardiovascular research. Its chemical structure facilitates various synthetic pathways in the creation of effective therapeutics. -
Drug Impurity
Tamsulosin impurity 5 is a known impurity associated with Tamsulosin, a selective alpha-1 adrenergic receptor antagonist primarily used to treat benign prostatic hyperplasia. This specific impurity plays a crucial role in quality control and analytical studies aimed at evaluating the purity and stability of Tamsulosin formulations. It is essential for researchers focusing on the pharmacokinetics and safety profiles of the drug. -
Drug Impurity
Mirabegron impurity 12 is a known impurity associated with the pharmaceutical compound Mirabegron, which primarily acts as a β3-adrenergic receptor agonist. This impurity may be important for analytical characterization and quality control in pharmaceutical research and development. Its detection and quantification can aid in understanding the safety and efficacy profiles of Mirabegron formulations.
