Catalog No.
Product Name
Application
Product Information
Citations
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Endothelin ETA Receptor Antagonist
S-1255 is a highly selective endothelin ETA receptor antagonist with a dissociation constant (Kd) of 0.39 nM. This compound effectively inhibits vasoconstriction, leading to sustained hypotensive effects in hypertensive animal models. S-1255 serves as a valuable tool in the study of hypertension and related cardiovascular disorders, providing insights into the endothelin signaling pathway and its role in vascular regulation. -
Endothelin-A Antagonist
BMS-187308 is an orally active antagonist of the endothelin-A (ETA) receptor, exhibiting a Ki of 4.7 nM for ETA and a Ki of 1.7 μM for ETB. This compound effectively inhibits the pressor response to endothelin-1 (ET-1) with an ED25 value of 1.2 µmol/kg when administered intravenously. BMS-187308 serves as a valuable tool for research focused on the physiological and pathophysiological roles of endothelin in various biological systems. -
Endothelin Receptor Agonist
Sarafotoxin S6b is a potent vasoconstrictor peptide and a non-selective agonist of endothelin receptors. This compound effectively induces contraction in isolated human coronary arteries, exhibiting Ki values of 0.27 nM, 0.55 nM, and 19.5 nM for the coronary artery, saphenous vein, and coronary artery, respectively. Sarafotoxin S6b is valuable for research applications focused on cardiovascular physiology and the roles of endothelin signaling in vascular constriction. -
Endothelin (ETA) Receptor Antagonist
CI-1020 is a selective antagonist of the endothelin (ETA) receptor, exhibiting an IC50 value of 0.3 nM. This compound effectively inhibits intimal hyperplasia in human saphenous vein organ culture. Furthermore, CI-1020 demonstrates potential in the treatment of hypoxic pulmonary hypertension by blocking ET-1-induced pressor responses following oral administration, making it a valuable tool for research in vascular biology and cardiovascular diseases. -
Endothelin A Receptor Antagonist
Fandosentan potassium is a selective antagonist of the endothelin A receptor (ETAR). It effectively reverses hypoxic pulmonary vasoconstriction in perinatal lamb models, making it a valuable tool for investigating pulmonary hypertension. Additionally, Fandosentan potassium inhibits the activities of CYP2C9 and CYP3A4 with IC50 values of 39.6 μM and 21.6 μM, respectively, supporting its application in exploring drug metabolism and interactions. -
ETB Receptor Agonist
BQ-3020 is a selective endothelin receptor (ETB receptor) agonist known for its ability to displace [125I] ET-1 binding at ETB receptors, exhibiting an IC50 of 0.2 nM. This compound induces vasoconstriction in the rabbit pulmonary artery and promotes relaxation of the pig urinary bladder neck. BQ-3020 is valuable for research in cardiovascular diseases, providing insights into endothelin signaling pathways and their physiological implications. -
ETA Receptor Antagonist
PD 155080 is a selective antagonist of the endothelin A (ETA) receptor. It effectively reduces coronary resistance in isolated rat heart models and enhances both systolic and diastolic myocardial function in ischemia/reperfusion studies. This reagent is valuable for research focused on cardiovascular diseases, including the investigation of endothelin's role in cardiac function and pathology. -
Endothelin converting enzyme inhibitor
Daglutril targets the endothelin receptor, exhibiting the ability to modulate cytokine-induced endothelin-1 production in astrocytes. Its inhibitory effects on endothelin-1 generation make it a valuable research tool for screening compounds that regulate this peptide's synthesis in glial cells. This compound is particularly relevant for studies investigating the role of endothelin-1 in neuroinflammation and related neurological disorders. -
Endothelin Receptor Antagonist
TAK 044 is an antagonist of the Endothelin Receptor, exhibiting potent inhibitory effects on endothelin-induced pathological changes in various animal models. This compound is valuable for exploring the role of endothelin in diseases such as acute myocardial infarction, acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage. Researchers can leverage TAK 044 to investigate therapeutic strategies targeting endothelin-related conditions. -
Endothelin Antagonist
PD 156252 is a highly potent endothelin antagonist, primarily targeting the ETA and ETB receptor subtypes. It exhibits enhanced binding affinity with IC50 values of 1.0 nM for rabbit ETA receptors and 40 nM for rat ETB receptors. This compound is valuable for research applications focusing on the endothelin system, cardiovascular studies, and investigations into related pathophysiological conditions. -
ETA Receptor Antagonist
BQ-610 is a selective antagonist of the endothelin A receptor (ETA), functioning as a competitive inhibitor of endothelin-1 (ET-1) binding. This inhibition leads to the attenuation of vascular smooth muscle contraction, reduction in cell mitosis, and diminished hormone secretion. BQ-610 has demonstrated efficacy in alleviating cerebral vasospasm in animal models, inhibiting bronchial epithelial and pulmonary vascular cell proliferation induced by cigarette smoke, and delaying natural luteal regression in bovine reproduction. This reagent is valuable for research focusing on vasospasm, abnormal cellular proliferation, and reproductive endocrine disorders. -
Macitentan Metabolite
ACT-373898 is the inactive carboxylic acid metabolite of Macitentan, a non-peptide dual antagonist of ETA and ETB endothelin receptors. This compound serves as a valuable reference for studies examining the pharmacokinetics and metabolic pathways of Macitentan. Its characterization is essential for understanding the therapeutic efficacy and safety profiles associated with endothelin receptor modulation in cardiovascular research. -
Endothelin Receptor Antagonist
TA-0201 is a competitive, non-peptide antagonist targeting endothelin receptors. It effectively inhibits the binding of [125I]ET-1 to cloned human ETA and ETB receptors, demonstrating Ki values of 15 pM and 41 nM, respectively. TA-0201 further reduces the pressor response induced by exogenous big ET-1, making it a valuable tool for studies aimed at understanding endothelin-mediated pathways and potential therapeutic interventions in cardiovascular research. -
Histamine Methylated Product
3-Methylhistamine dihydrochloride is a methylated derivative of histamine that serves as a significant biomarker in the study of immune responses. This compound has been shown to be upregulated in vaccinated murine models, making it useful for research applications focused on immunological studies and histamine-related pathways. Its role in the modulation of immune activity positions it as a valuable reagent in exploring allergic reactions and other histamine-mediated processes. -
PAF Analog
2-Thio-PAF is a synthetic analog of platelet-activating factor (PAF) that serves as a valuable tool for studying PAF metabolism. It effectively inhibits PAF acetylhydrolases, allowing researchers to assess enzyme activity through colorimetric assays. This compound is significant in investigating various biological processes influenced by PAF signaling, including inflammation and cellular responses. -
Biochemical Assay Reagent
Pinolenic acid ethyl ester is a derivative of pinolenic acid, a polyunsaturated fatty acid known for its lipid-regulating properties. This reagent is used in biochemical assays to study appetite regulation and lipid metabolism due to its ability to enhance satiety hormone levels such as CCK and GLP-1, contributing to appetite suppression. Research indicates that pinolenic acid can diminish arachidonic acid levels in hepatic cells, making it relevant for studies investigating cholesterol efflux and fatty acid metabolism. Its lipophilic nature allows for versatile applications in various biochemical studies targeting metabolic pathways. -
Phenethylamine
α-Ethyl 2C-D hydrochloride is a phenethylamine derivative that acts primarily on serotonin and dopamine receptors. This compound exhibits significant psychoactive properties and has been utilized in research to explore the effects of amphetamines and their analogs. It serves as a reference standard in drug discrimination studies, particularly for understanding the pharmacological profiles of MDMA. -
Lipid
C18:1 Anandamide is an endocannabinoid lipid that primarily targets cannabinoid receptors, particularly CB1 and CB2. It exhibits various biological activities, including modulation of pain, appetite, and mood. C18:1 Anandamide is widely utilized in research focused on the endocannabinoid system, neurobiology, and the therapeutic potential of cannabinoids in a range of physiological processes and disorders. -
Lipid
N-20:4 L-Serine MeEster is a lipid-derived compound that functions as a structural analog of anandamide. It exhibits significant biological activity in modulating cannabinoid receptor signaling pathways, making it a valuable reagent for studying lipid-mediated cellular processes. This compound is useful in various research applications, including investigations of endocannabinoid system dynamics and lipid signaling in neurobiology. -
Lipid
C17:0 Anandamide phosphate sodium is a lipid derivative of anandamide, primarily targeting cannabinoid receptors. This compound possesses bioactive properties that may influence various physiological pathways, making it a valuable tool in studies related to endocannabinoid signaling, lipid metabolism, and neurobiology. Its applications include investigating the role of lipid mediators in inflammation, pain, and neurodegenerative diseases. -
Antianxiety Compound
Fluprazine is an anxiolytic compound that primarily targets neurotransmitter systems to alleviate anxiety symptoms. This compound exhibits key biological activity in modulating serotonin and dopamine receptors, making it relevant in the study of various psychiatric disorders. Researchers utilize Fluprazine for investigating therapeutic approaches in anxiety and related mood disorders. -
Lipid
C20:4 Anandamide (AEA) is a bioactive lipid that acts as an endocannabinoid, primarily targeting cannabinoid receptors in the central nervous system. This compound is known for its involvement in pain modulation, appetite regulation, and neuroprotection. C20:4 AEA is commonly utilized in research to investigate the physiological effects of endocannabinoids and their potential therapeutic applications in various neurological and inflammatory conditions. -
Biochemical Assay Reagent
CGS 21680 sodium is an adenosine A2A receptor agonist that selectively activates the A2A receptor, influencing various signaling pathways. This compound exhibits biological activities such as modulation of neurotransmission and anti-inflammatory effects, making it useful in research involving neurological and cardiovascular studies. It is commonly employed in biochemical assays to explore the roles of adenosine receptors in cellular processes and their potential therapeutic applications. -
Biochemical Assay Reagent
Oleoylsulfamide is a selective inhibitor of cannabinoid receptor 1 (CB1). This compound can be utilized as a biochemical assay reagent to investigate the role of CB1 in various physiological processes. It is particularly valuable in studies related to metabolic disorders, pain modulation, and neuroprotection. -
Lipid
C17:1 Anandamide is a synthetic derivative of anandamide, a significant endocannabinoid that interacts primarily with cannabinoid receptors. This compound demonstrates key biological activities, including modulation of pain perception, appetite, and mood regulation. C17:1 Anandamide is useful for studying the endocannabinoid system and its implications in various therapeutic areas, such as neurobiology and pain management. Its unique lipid structure enables investigations into lipid signaling pathways and their role in cellular processes. -
Lipid
NBD AA is a fluorescent analog of anandamide that selectively targets cannabinoid receptors. This compound plays a critical role in lipid signaling pathways and is utilized in studies examining endocannabinoid system functions. Its fluorescent properties make NBD AA an effective tool for visualizing lipid distribution and activity in live cell imaging and various biochemical assays. -
Lipid
N-Arachidonoyl-L-Serine sodium is a lipid compound that acts as an analog of anandamide, a well-known endocannabinoid. This reagent exhibits important biological activities, including the modulation of pain sensation, inflammation, and neuroprotection. It is utilized in research exploring cannabinoid receptor pathways and their therapeutic potential in various neurological and inflammatory disorders. -
Lipid
C18:2 Anandamide phosphate sodium is a phospholipid derivative of anandamide, acting primarily on cannabinoid receptors. This compound exhibits bioactive properties that influence lipid signaling pathways and modulate neuronal communication. It is applicable in research exploring endocannabinoid system dynamics, neuroprotection, and potential therapeutic avenues for neurological disorders. -
Lipid
N-Oleoyl-L-serine sodium is an analog of anandamide that primarily targets lipid signaling pathways. This compound exhibits notable biological activity as a cannabinoid receptor modulator, influencing physiological processes such as pain perception and inflammation. It is frequently used in research applications focused on neurobiology and lipid metabolism. -
Platelet Aggregation Inhibitor
Cloricromen is a potent platelet aggregation inhibitor that functions by targeting the mechanisms involved in thrombus formation. Demonstrating efficacy in inhibiting platelet aggregation in both human subjects and experimental models, Cloricromen is a valuable reagent for research in cardiovascular disease and thrombotic disorders. Its application in studying platelet function and related pathologies makes it an essential tool for investigations in vascular biology. -
Neuroleptic Agent
Fenaperone hydrochloride is a neuroleptic agent that primarily targets dopamine receptors in the central nervous system. It exhibits antipsychotic properties, making it relevant for research in neurological disorders and psychiatric conditions. Its mechanism includes modulation of neurotransmitter activity, contributing to its potential therapeutic effects in various mental health applications. -
Biochemical Assay Reagent
1,3-Dipropyl-7-methylxanthine is a selective antagonist of adenosine receptors, primarily targeting the A1 subtype. It exhibits potent inhibitory effects on adenosine-mediated signaling pathways, making it valuable in biochemical assays for studying adenosine receptor functions. This compound is commonly utilized in research examining cellular processes influenced by adenosine, such as neurotransmission, inflammation, and metabolic regulation. -
Biochemical Assay Reagent
5'-Ethylcarboxamido-2',3'-isopropylidene adenosine is a selective agonist targeting A2B adenosine receptors. This compound enhances A2B receptor activity, making it valuable for investigating the physiological roles of adenosine signaling in various biological processes. It serves as a pertinent tool in biochemical assays and research applications aimed at understanding adenosine's effects and its potential as a therapeutic target in drug development. -
Biochemical Reagent
Nestifylline is a biochemical reagent that functions primarily as an antagonist of adenosine receptors. It exhibits significant activity in modulating airway constriction, making it a valuable tool for studying respiratory diseases, particularly bronchospasm. Researchers can utilize Nestifylline to explore mechanisms underlying airway responsiveness and potential therapies for respiratory disorders. -
PGF2α Analog
Fenprostalene is a potent analog of prostaglandin F2α (PGF2α) that primarily targets the prostaglandin pathway. This compound is effective in veterinary medicine for inducing corpus luteum regression and lowering blood progesterone levels in dogs. Its primary applications include the treatment of pyometra and the induction of abortion, making it a critical reagent in reproductive health studies and veterinary practices. -
Amino Acid Derivatives
H-Lys(Fmoc)-OH hydrochloride is an amino acid derivative featuring an Fmoc protecting group. This compound serves as a key intermediate for the synthesis of diacylated GLP-1 derivatives, which possess antidiabetic properties. Its utility in peptide synthesis makes it an important reagent in chemical biology and drug development. -
Amino Acid Derivatives
Boc-Leu-OH hydrate (N-Boc-L-leucine monohydrate) is a protected form of the amino acid leucine, featuring a Boc protecting group. It serves as a useful intermediate in peptide synthesis, particularly for the generation of L-prolyl-L-leucyl-glycinamide, a peptide mimetic known for its modulatory effects on dopamine receptors. This compound is valuable in research focused on neuropharmacology and peptide therapeutics. -
Drug Intermediate
Fmoc-Lys(tBuO-Ara-Glu(AEEA-AEEA)-OtBu)-OH is a key drug intermediate in the synthesis of Tirzepatide, which functions as a dual agonist of the glucose-dependent insulinotropic peptide (GIP) and the glucagon-like peptide-1 receptor (GLP-1R). This compound is essential for research and development in diabetes therapeutics, as Tirzepatide enhances insulin secretion and improves glycemic control. Its structural features facilitate the exploration of peptide-based treatments for metabolic disorders. -
Piperazine
1-Benzyl-3-methylpiperazine is a piperazine derivative that primarily functions as a monoamine receptor ligand. It exhibits significant activity at various serotonin and dopamine receptors, making it a valuable compound for research in neuropharmacology. This reagent is often utilized in studies exploring the effects of psychoactive substances and the mechanisms underlying mood regulation. -
Piperazine
MDBP hydrochloride is a piperazine derivative that acts as a central nervous system modulator. It demonstrates significant biological activity by influencing serotonin and dopamine receptors, making it a valuable tool for neuroscience research. This compound is useful for investigating psychiatric disorders and exploring the pharmacological effects of piperazine analogs. -
Derivative of Clonidine
Acetylclonidine is a derivative of Clonidine that targets imidazoline and adrenergic receptors. It exhibits biological activity in reducing intraocular pressure, making it a valuable reagent for research into ocular antihypertensive agents for the treatment of glaucoma. Its unique profile may provide insights into novel therapeutic approaches in ocular health. -
Amisulpride Photodegradation Product
Amisulpride N-oxide is a photodegradation product of Amisulpride, which acts as a dopamine D2/D3 receptor antagonist. This compound may be relevant for studies investigating the stability and degradation pathways of Amisulpride under light exposure. Its characterization can aid researchers in understanding the pharmacokinetics and metabolic processes associated with dopamine receptor modulation. -
Aminoalkylindole Derivative
7'-Methoxy NABUTIE is a derivative of aminoalkylindole that primarily targets cannabinoid receptors. This compound is recognized for its potential biological activity in modulating the effects associated with alcohol consumption. Research applications include investigations into the pathways of alcohol abuse and the exploration of therapeutic strategies for addiction. -
Platelet Aggregation Inhibitor
4-Trifluoromethylsalicylic acid, also known as Desacetyl triflusal, functions as a platelet aggregation inhibitor. This compound is instrumental in research related to cardiovascular disorders, particularly in the study of thrombus formation and prevention. Its ability to modulate platelet activity makes it a valuable tool for investigating hematological processes and developing antithrombotic therapies. -
Tetrahydrocannabinol Analogues
8-Oxo-Δ9-THC is an oxygenated analog of tetrahydrocannabinol that exhibits significant interaction with cannabinoid receptors in the endocannabinoid system. This compound demonstrates notable biological activity, which may influence various cellular signaling pathways involved in pain modulation, inflammation, and neuroprotection. Its potential applications include research into therapeutic effects associated with cannabinoid compounds as well as studies investigating the pharmacological properties of cannabis-derived substances. -
Desfluorinated Nebivolol Isomer
Desfluoro nebivolol is a desfluorinated isomer of the antihypertensive agent nebivolol, primarily acting as a beta-adrenergic receptor blocker. This compound exhibits pharmacological activity related to cardiovascular regulation, making it relevant for research in hypertension and heart failure therapies. Its unique chemical structure allows for exploration of β-blockade mechanisms and potential therapeutic benefits, providing valuable insights for the development of cardiovascular treatments. -
Piperazine
2-BZP is a piperazine compound that functions as a central nervous system stimulant by targeting serotonin and dopamine receptors. Its primary biological activity includes modulation of neurotransmitter release, making it useful in research related to neuropharmacology and behavioral studies. 2-BZP serves as a valuable tool for elucidating the mechanisms of psychostimulant effects and exploring potential therapeutic applications. -
Drug Derivative
Cetamolol is a drug derivative that primarily targets beta-adrenergic receptors. It exhibits significant cardioprotective effects and is utilized in research focusing on cardiovascular pharmacology. Its ability to modulate heart rate and blood pressure makes it valuable for investigating hypertension and related cardiovascular disorders. -
Piperazine
1-(3-Chloro-4-fluorophenyl)piperazine hydrochloride is a piperazine derivative that acts as a potent and selective modulator of various neurotransmitter systems. This compound is primarily utilized in neuroscience research to investigate its effects on serotonin and dopamine receptors, contributing to the understanding of mood disorders and psychotropic drug action. Its unique chemical structure makes it valuable for studies related to pharmacology and medicinal chemistry. -
Drug Derivative
1(R)-Tetrahydrocannabidiol is a drug derivative known for its interaction with cannabinoid receptors. It exhibits potential neuroprotective activity, making it a valuable tool for investigating neurological diseases and disorders. This compound facilitates research into the therapeutic effects of cannabinoids in various neurobiological contexts.
