PF-5274857 hydrochloride is a potent, selective antagonist of Smoothened (Smo) with an IC50 of 5.8 nM and a Ki of 4.6 nM. Its oral bioavailability and ability to penetrate the blood-brain barrier enhance its utility in research on tumors, particularly brain tumors and brain metastases associated with an activated Hedgehog (Hh) signaling pathway. This compound is valuable for studies aimed at understanding Smo-mediated tumorigenesis and developing targeted therapeutics.
PF-5274857 hydrochloride is a potent, selective antagonist of Smoothened (Smo) with an IC50 of 5.8 nM and a Ki of 4.6 nM. Its oral bioavailability and ability to penetrate the blood-brain barrier enhance its utility in research on tumors, particularly brain tumors and brain metastases associated with an activated Hedgehog (Hh) signaling pathway. This compound is valuable for studies aimed at understanding Smo-mediated tumorigenesis and developing targeted therapeutics.
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