Signaling Pathway
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| Discription | A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively. | ||
|---|---|---|---|
| Targets |
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| Catalog Num | A11034 |
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| Formula | C22H22N4O |
| Molecular Weight | 358.4 |
| CAS Number | 552325-73-2 |
| SMILES | CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CC=CC=C4)N |
| Synonyms | A674563 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 71 mg/mL (198.08 mM) | |
| Water | 71 mg/mL (198.08 mM) | ||
| Ethanol | 18 mg/mL (50.21 mM) | ||
| In vivo | Saline | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.9 mL | 139.51 mL | 279.02 mL |
| 0.5 mM | 5.58 mL | 27.9 mL | 55.8 mL |
| 1 mM | 2.79 mL | 13.95 mL | 27.9 mL |
| 5 mM | 0.56 mL | 2.79 mL | 5.58 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
