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Akt inhibitor

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Catalog No. A11034

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
A-674563 5mg A11034-5

Regular Price: $140.00

Special Price: $126.00

A-674563 10mg A11034-10

Regular Price: $220.00

Special Price: $198.00

A-674563 25mg A11034-25

Regular Price: $400.00

Special Price: $360.00

A-674563 50mg A11034-50

Regular Price: $650.00

Special Price: $585.00

A-674563 10mM * 1mL in DMSO A11034-10mM-D

Regular Price: $159.00

Special Price: $143.10

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.


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Publications citing Adooq Products
A-674563 Citations (3)
  • Kobayashi T, .et al. A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1468-1475 PMID: 29196261
  • Lin Xu, .et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells, Biochem Biophys Res Commun, 2016, Apr 15;472(4):662-8 PMID: 26920060
  • Zou Y, .et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent, Biochem Biophys Res Commun, 2016, Aug 12;477(1):1-8 PMID: 26970307

Chemical Information

Catalog Num A11034
Actions Inhibitor
M. Wt 358.4
Formula C22H22N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 552325-73-2
Synonyms A674563
SMILES CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[[email protected]](CC4=CC=CC=C4)N

Biological Activity

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
Target Value
Akt1ki: 11nM
PKAki: 16nM
CDK2ki: 46nM
GSK-3βki: 110nM
ERK2ki: 260nM
PKCδki: 360nM
RSK2ki: 580nM
MAPK-AP2ki: 1.1μM
PKCγki: 1.2μM
FLT1ki: >2.2μM
Chk1ki: 2.6μM
KDRki: >3.7μM
CK2ki: 5.4μM
c-Kitki: >5.8μM
Srcki: 13μM
PDK-1ki: >20μM


Solubility (25°C) * In vitro DMSO 72 mg/mL (200.87 mM)
Water 72 mg/mL (200.87 mM)
Ethanol 18 mg/mL (50.21 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.9 mL 139.51 mL 279.02mL
0.5 mM 5.58 mL 27.9 mL 55.8 mL
1 mM 2.79 mL 13.95 mL 27.9 mL
5 mM 0.56 mL 2.79 mL 5.58 mL

*The above data is based on the productmolecular weight 358.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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