A-674563

Catalog No.: A11034

Akt inhibitor

A-674563 Chemical Structure

CAS NO. 552325-73-2

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

Availability: In stock

Package Price Qty
5 mg
$140.00
10 mg
$220.00
25 mg
$400.00
50 mg
$650.00
10mM * 1mL in DMSO
$159.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
Targets
Target Value
Akt1ki: 11nM
PKAki: 16nM
CDK2ki: 46nM
GSK-3βki: 110nM
ERK2ki: 260nM
PKCδki: 360nM
RSK2ki: 580nM
MAPK-AP2ki: 1.1μM
PKCγki: 1.2μM
FLT1ki: >2.2μM
Chk1ki: 2.6μM
KDRki: >3.7μM
CK2ki: 5.4μM
c-Kitki: >5.8μM
Srcki: 13μM
PDK-1ki: >20μM
In vitro (25°C) DMSO 72 mg/mL (200.87 mM)
Water 72 mg/mL (200.87 mM)
Ethanol 18 mg/mL (50.21 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.9 mL 139.51 mL 279.02 mL
0.5 mM 5.58 mL 27.9 mL 55.8 mL
1 mM 2.79 mL 13.95 mL 27.9 mL
5 mM 0.56 mL 2.79 mL 5.58 mL

*The above data is based on the productmolecular weight 358.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11034
Actions Inhibitor
M. Wt 358.4
Formula C22H22N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 552325-73-2
Synonyms A674563
SMILES CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[[email protected]](CC4=CC=CC=C4)N

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
You may also be interested in the following product(s)
Keywords:buy A-674563 | A-674563 Supplier | purchase A-674563 | A-674563 cost | A-674563 manufacturer | order A-674563 | A-674563 distributor | buy 552325-73-2| 552325-73-2 Supplier | purchase 552325-73-2 | 552325-73-2 cost | 552325-73-2 manufacturer | order 552325-73-2 | 552325-73-2 distributor
Rewards