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multi-AGC kinase inhibitor

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Catalog No. A12464

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
AT13148 5mg A12464-5
AT13148 10mg A12464-10
AT13148 25mg A12464-25
AT13148 10mM * 1mL in DMSO A12464-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.


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Chemical Information

Catalog Num A12464
Actions Inhibitor
M. Wt 313.78
Formula C17H16ClN3O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1056901-62-2
Synonyms AT 13148, AT-13148
SMILES C1=CC(=CC=C1C2=CNN=C2)[[email protected]@](CN)(C3=CC=C(C=C3)Cl)O

Biological Activity

AT13148 is a novel oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity, which shows a distinct mechanism of action from other AKT inhibitors.
Target Value
PKAIC50: 3nM
ROCK2IC50: 4nM
ROCK1IC50: 6nM
p70S6KIC50: 8nM
Akt1IC50: 38nM
Akt3IC50: 50nM
SGK3IC50: 63nM
RSK1IC50: 85nM
Akt2IC50: 402nM
Chk2IC50: 860nM
AuroraBIC50: 1860nM


Solubility (25°C)* In vitro DMSO 62 mg/mL (197.59 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.87 mL 159.35 mL 318.69mL
0.5 mM 6.37 mL 31.87 mL 63.74 mL
1 mM 3.19 mL 15.93 mL 31.87 mL
5 mM 0.64 mL 3.19 mL 6.37 mL

*The above data is based on the productmolecular weight 313.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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