Catalog No.
Product Name
Application
Product Information
Citations
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Autophagy Activator
Clematichinenoside AR is an autophagy activator derived from the traditional Chinese herb Clematis chinensis. This compound exhibits significant pharmacological effects, notably in the context of atherosclerosis and related diseases. Its ability to modulate autophagy makes it a valuable tool for research into cellular processes and potential therapeutic interventions. -
Autophagy Inhibitor
Autophagy-IN-5 is a potent autophagy inhibitor, exhibiting an EC50 of 0.736 μM. This compound selectively targets the autophagy pathway, playing a crucial role in cellular homeostasis and degradation processes. It is suitable for research applications investigating the modulation of autophagy in various disease contexts, including cancer and neurodegenerative disorders. -
Autophagy
SLLN-15 is a potent and selective enhancer of autophagy that primarily targets the autophagic pathway. It effectively activates cytostatic macroautophagy in triple-negative breast cancer (TNBC) cells, promoting cellular degradation and recycling processes. SLLN-15 is ideal for research focused on autophagy modulation and its implications in cancer therapy, particularly in challenging malignancies like TNBC. -
Autophagy
MRT 68601 is a potent inhibitor of TBK1, predominantly influencing autophagy processes. It effectively inhibits autophagosome formation in lung cancer cells, underscoring its therapeutic potential in cancer research. Additionally, MRT 68601 may impact host-dependent factors implicated in SARS-CoV-2 infection, offering a foundation for the development of broad-spectrum antiviral therapies linked to known FDA-approved drugs and compounds currently in clinical trials. -
Autophagy Inducer
Butylate is an autophagy inducer that plays a significant role in platelet research. It is involved in the activation of platelets, which can trigger autophagic processes mediated by the AMPK-MTOR signaling pathway and is associated with sphingolipid metabolism. This compound serves as a valuable tool for investigating the interplay between autophagy and metabolic pathways in hematological studies. -
Autophagy Inducer
NSC 109555 is an ATP-competitive inhibitor of checkpoint kinase 2 (Chk2), exhibiting an IC50 of 200 nM in a cell-free assay. This compound selectively inhibits Chk2 while displaying lesser activity against Brk, c-Met, IGFR, and LCK at higher concentrations. NSC 109555 disrupts Chk2 autophosphorylation and histone H1 phosphorylation with an IC50 of 240 nM. Its biological activity includes inducing autophagy and inhibiting growth in L1210 leukemia cells, as well as enhancing gemcitabine-induced cytotoxicity and increasing reactive oxygen species levels in various pancreatic cancer cell lines. -
Autophagy Inducer
BRD5631 is an autophagy inducer that enhances the autophagic process through an mTOR-independent pathway. It has been shown to impact various cellular disease phenotypes associated with autophagy, including protein aggregation, cell survival mechanisms, bacterial replication, and the production of inflammatory cytokines. This compound is suitable for research applications exploring the roles of autophagy in disease modulation and therapeutic development. -
Autophagy Activator
501A054 is an autophagy activator that promotes autophagy-dependent cell death through the activation of autophagy pathways. This compound is valuable for research applications focused on the regulation of autophagy, particularly in the context of cervical cancer studies. Its ability to induce autophagic processes makes it a significant tool for understanding cellular mechanisms and therapeutic strategies in cancer research. -
Autophagy Activator
Soybean peptide QRPR is an autophagy activator that enhances cellular autophagy by increasing the expression and activity of key signaling proteins, including PIK3, AKT, and mTOR. This peptide has shown potential in reducing inflammatory responses, making it valuable for research in cellular stress responses and inflammatory diseases. Its role in modulating autophagy pathways positions it as an important tool for studies aimed at understanding cellular homeostasis and therapeutic interventions. -
Autophagy Inducer
Cabergoline diphosphate is an ergot alkaloid that acts as an agonist of dopamine D2-like receptors, demonstrating high affinity for D2, D3, and 5-HT2B receptors with Ki values of 0.7, 1.5, and 1.2, respectively. It serves as an autophagy inducer, making it a valuable tool for research focused on cellular processes related to autophagy and neurobiology. This compound is instrumental in studies investigating neurodegenerative diseases and metabolic regulation, providing insights into the role of dopamine receptors in cellular homeostasis. -
Autophagy
Calmodulin-Dependent Protein Kinase II (290-309) is a specific antagonist of CaMK with a reported IC50 of 52 nM, effectively inhibiting calmodulin-dependent protein kinase II activity. This reagent plays a crucial role in the study of autophagy, facilitating research into cellular signaling pathways regulated by calcium and calmodulin. It is valuable for investigating the physiological and pathological processes influenced by CaMKII, providing insights into various diseases and potential therapeutic targets. -
Autophagy Inducer
Autophagonizer (DK-1-49) is a small molecule autophagy inducer that promotes the accumulation of autophagy-associated LC3-II while increasing the levels of autophagosomes and acidic vacuoles. This compound effectively inhibits cell viability and induces cell death in cancer cells as well as Bax/Bak double-knockout cells, demonstrating EC50 values of 3-4 μM. Autophagonizer serves as a valuable tool for research into autophagy-related processes and potential therapeutic interventions in cancer biology. -
Autophagy Inhibitor
ATG12-IN-1 is an autophagy inhibitor that effectively disrupts the ATG12-ATG3 protein-protein interaction, exhibiting an IC50 of 9 μM. This compound is valuable in cancer research, allowing for the exploration of autophagy dynamics and its implications in tumor biology. It provides a robust tool for investigating the role of autophagy in cancer progression and therapeutic resistance. -
Autophagy-Targeting Chimera
2G-HaloAUTAC is a second-generation autophagy-targeting chimera designed to enhance the efficacy of AUTACs by substituting the L-Cysteine linker with alternative structures. This compound demonstrates potent degradation activity against EGFP-HaloTag protein via an autophagic mechanism. It serves as a valuable tool for research focused on autophagy and targeted protein degradation, providing insights into cellular protein turnover processes. -
Autophagy Inhibitor
Autophagy-IN-4 (Compound 34) is a potent autophagy inhibitor, demonstrating an EC50 of 0.5 μM in U2OS cells and an LD50 of 27 μM. This compound effectively interferes with the autophagic process, making it a valuable tool for researchers investigating the role of autophagy in various biological contexts and disease models. Its specificity and efficacy support its application in studies aimed at understanding autophagy-related pathways and potential therapeutic interventions. -
Autophagy Inhibitor
Autophagy-IN-3 is an autophagy inhibitor that enhances metabolic stress within the tumor microenvironment. By inhibiting autophagic processes, it significantly increases the efficacy of cytostatics in combination therapies. This compound is particularly valuable in cancer research, where modulating autophagy can influence tumor growth and treatment response. -
Autophagy Inducer
CR-3294 is an autophagy inducer that specifically targets hypoxic cells by inhibiting inducible nitric oxide synthase (iNOS). It effectively inhibits the DNA binding activity of HIF-1alpha and reduces VEGF mRNA synthesis. This compound is valuable for research applications involving breast cancer and inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, by elucidating the role of autophagy in these conditions. -
Autophagy Inducer
SMER10 is a small-molecule autophagy inducer that enhances the formation of autophagosomes. This compound promotes the conversion of LC3-I to the autophagosome-associated form, LC3-II, thereby increasing the number of EGFP-LC3 positive structures in COS-7 and HeLa cells. SMER10 has been shown to facilitate the degradation of autophagic substrates such as the mutant huntingtin protein (EGFP-HDQ74) linked to Huntington's disease and A53T α-synuclein associated with Parkinson's disease, demonstrating its neuroprotective properties in relevant cellular models. -
Autophagy Inducer
Isodunnianol is a novel autophagy inducer that enhances autophagic activity by increasing the expression of pAMPK172 and pULK1555 while simultaneously reducing levels of pULK1757 and SQSTM2. This compound has demonstrated the ability to mitigate doxorubicin-induced cardiotoxicity, making it a valuable tool for research in cardioprotection and autophagy-related pathways. Its application can further advance studies related to cancer therapy and cellular stress responses. -
Autophagy Inducer
Amsacrine (gluconate) is an inhibitor of topoisomerase II, primarily functioning as an autophagy inducer. This compound exhibits significant antineoplastic activity by intercalating into the DNA of tumor cells, disrupting their replication and promoting cell death. Amsacrine (gluconate) is commonly utilized in cancer research to explore mechanisms of tumor growth inhibition and the roles of autophagy in cancer treatment. -
Autophagy Inducer
Chromomycin A2 is an autophagy inducer known for its cytotoxic properties. This compound exhibits significant anti-tumor activity, making it a valuable tool in cancer research. Its ability to modulate autophagy pathways allows for investigation into cancer cell survival and proliferation, facilitating studies focused on therapeutic interventions. -
Autophagy Activator
AR493 is an autophagy activator that targets AMPK (adenosine monophosphate-activated protein kinase). It modulates pathways involved in cellular energy sensing, leading to increased levels of autophagy. This compound is valuable for research into aging-associated disorders, including diabetes and neurodegenerative diseases, as well as for studies on autophagy regulation. -
Autophagy Inhibitor
Autophagy-IN-C1 is a potent autophagy inhibitor that effectively inhibits the autophagic process in hepatocellular carcinoma (HCC) cells. In addition to its role in blocking autophagy, this compound also induces apoptosis, making it a valuable tool for investigating cell death mechanisms and therapeutic strategies in cancer research. Its dual activity provides insights into the interplay between autophagy and apoptosis in tumor biology. -
Autophagy Inhibitor
Autophagy-IN-7 is an autophagy inhibitor that targets the autophagic process in cells. It is primarily utilized in cancer research to investigate the effects of autophagy modulation on tumor progression and treatment response. This compound serves as a valuable tool for elucidating the role of autophagy in various cellular mechanisms and cancer biology. -
Autophagy
(1R)-cis-Bifenthrin is a synthetic pyrethroid that targets autophagy pathways, particularly affecting motor coordination. Research indicates that (1R)-cis-Bifenthrin exposure leads to decreased motor function in ParKin-/- mice, evidenced by prolonged pole climbing times and reduced wheel running activity. The compound significantly decreases the number of tyrosine hydroxylase-positive cells and alters protein expression levels. Notably, (1R)-cis-Bifenthrin promotes the expression of mitophagy-related proteins, including LC3B and p62, while demonstrating enhanced binding affinity for transferrin and transferrin receptor 2. These interactions underscore its role in mitophagy and ferroptosis-related signaling pathways. -
Autophagy Inducer
8-Nitro-cGMP is an electrophilic second messenger involved in redox signaling that acts through the formation of protein-S-cGMP adducts via the s-guanylation process. This compound serves as an inducer of autophagy, demonstrating significant biological activity in promoting RANKL-induced osteoclast differentiation from macrophages. Additionally, 8-Nitro-cGMP exhibits vasodilatory effects and has been shown to improve vascular endothelial dysfunction in diabetic mouse models, making it a valuable tool for research in cellular signaling and metabolic disorders. -
Autophagy
SW063058 is an autophagy inducer that selectively disrupts the interaction between Beclin 1 and Bcl-2, while preserving the binding of Bcl-2 to pro-apoptotic proteins such as Bax and BIM. This selective inhibition relieves the negative regulatory effects of Bcl-2 on Beclin 1, thereby enhancing autophagic activity. SW063058 promotes autophagy in vitro without inducing cytotoxicity, apoptosis, or other forms of cell death, making it a valuable tool for studying autophagic processes in various biological contexts. -
Autophagy Inhibitor
CP 53631 is an autophagy inhibitor that demonstrates anticancer activity by disrupting the autophagic process in cancer cells. This compound can also serve as an internal standard in studies examining selective serotonin reuptake inhibitors (SSRIs) such as Sertraline, making it valuable for research in antidepressant mechanisms and effects. Its dual applications in oncology and neuropharmacology underscore its significance in advancing both fields. -
Autophagy Inhibitor/Ionic Compound
Ammonium chloride is an ionic compound known for its role as an autophagy inhibitor. By inducing intracellular alkalization, it can disrupt lysosomal function and alter enzymatic activity, leading to metabolic acidosis. This compound is widely utilized in research applications focused on autophagy modulation and lysosomal pathway studies. -
Autophagy Inhibitor; p62 ZZ Domain Inhibitor
XRK3F2 is a selective inhibitor of the p62 (sequestosome-1) ZZ domain, demonstrating potent inhibition of autophagy processes. This compound effectively blocks TNFα-induced signaling in bone marrow stromal cells and promotes apoptosis in multiple myeloma cells. XRK3F2 is valuable for research applications targeting multiple myeloma bone disease and acute myeloid leukemia, providing insights into cell survival mechanisms and autophagic regulation in hematological malignancies. -
Autophagy Inducer
Eupatilin is a lipophilic flavonoid extracted from Artemisia argyi Lévl. et Van. that acts as an autophagy inducer and PPARα agonist. It demonstrates significant anti-apoptotic, anti-oxidative, and anti-inflammatory activities. This compound is valuable for research in cellular stress responses, inflammation, and neuroprotection studies. -
Cytokinin Nucleoside/Autophagy Inhibitor
N6-Isopentenyladenosine, a cytokinin nucleoside, acts primarily as an autophagy inhibitor. This compound, derived from the mevalonate pathway, has demonstrated notable anti-melanoma activity. Additionally, it plays a critical role in RNA modification, enhancing the efficiency and accuracy of translation in certain tRNAs and regulating plant growth and differentiation. Research applications include investigations into autophagy-related mechanisms and the development of therapeutic strategies for melanoma. -
Autophagy Inducer
Oxyresveratrol is a potent autophagy inducer with significant antioxidant properties, exhibiting an IC50 of 28.9 µM against DPPH free radicals. It serves as a noncompetitive inhibitor of tyrosinase, demonstrating an IC50 value of 1.2 µM for mushroom tyrosinase. Oxyresveratrol has been shown to exhibit antiviral activity against HSV-1, HSV-2, and varicella-zoster virus, as well as providing neuroprotective effects. This compound is valuable for research into cellular protection mechanisms and the regulation of metabolic processes. -
Autophagy Inducer
BGT226 is a dual inhibitor targeting PI3K and mTOR, demonstrating IC50 values of 4 nM, 63 nM, and 38 nM against PI3Kα, PI3Kβ, and PI3Kγ, respectively. This compound effectively induces autophagy, showcasing significant growth-inhibitory effects in human head and neck cancer cells. BGT226 is valuable for research in cancer biology and drug development focused on autophagy modulation and PI3K/mTOR signaling pathways. -
Autophagy Inhibitor
DC-LC3in-D5 functions as an autophagy inhibitor by inhibiting the lipidation of LC3B. It effectively binds to LC3B and disrupts the interaction with LBP2, exhibiting an IC50 value of 200 nM. This compound is valuable in research focused on the modulation of autophagy, contributing to investigations of anti-HCV therapies and potential cancer treatments through autophagy inhibition. -
Autophagy Inducer
Sedanolide is a natural compound recognized for its role as an autophagy inducer. This compound exhibits significant anti-inflammatory and antioxidant properties, making it valuable in various biological research applications. Its ability to modulate cellular processes associated with autophagy allows researchers to explore its potential therapeutic effects in diseases linked to autophagic dysfunction. -
Autophagy Activator
Ginkgolide K is an autophagy activator derived from Ginkgo biloba. It stimulates protective autophagy by modulating the AMPK/mTOR/ULK1 signaling pathway, thereby promoting cellular survival. Additionally, Ginkgolide K exhibits neuroprotective properties, making it a valuable tool for research in neurobiology and cellular stress responses. -
Autophagy Inducer
Pyriproxyfen acts as a juvenile hormone analog, primarily targeting larval development by inhibiting the transition to adulthood. This mechanism effectively reduces reproductive capabilities in various insect species. Pyriproxyfen is widely utilized in chemical research to study autophagy induction and its implications in pest control and developmental biology. -
Autophagy Inhibitor
ATG7-IN-1 is a selective inhibitor of the autophagy-related protein ATG7, exhibiting an IC50 of 62 nM. This compound interferes with autophagy processes by disrupting the function of ATG7, making it a valuable tool for research in autophagy regulation. It is particularly useful for studies investigating the role of autophagy in various diseases, including cancer and neurodegenerative disorders. -
Autophagy Inducer
Pemetrexed disodium heptahydrate is an innovative antifolate that serves as an autophagy inducer. It effectively inhibits key enzymes including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with Ki values of 1.3, 7.2, and 65 nM, respectively. This compound is valuable in research applications targeting metabolic pathways and autophagic processes in cancer and other diseases. -
Autophagy Inhibitor
Autogramin-2 is a potent autophagy inhibitor that effectively blocks autophagy triggered by nutrient deprivation, demonstrating an IC50 of 0.27 μM, as well as autophagy induced by mTORC1 inhibition with Rapamycin, with an IC50 of 0.14 μM. This compound is valuable for studying the role of autophagy in cellular processes and various diseases, including cancer and neurodegeneration. Its ability to modulate autophagic pathways makes it an essential tool for researchers investigating autophagy's impact on cell survival and metabolism. -
Autophagy Inducer
XIE62-1004-A is a potent inducer of p62-LC3 interaction, specifically targeting the ZZ-domain of p62. Its binding induces p62 oligomerization, thereby activating p62-dependent autophagy processes. This compound is valuable for research applications investigating the mechanisms of autophagy and its role in cellular homeostasis and disease. -
Autophagy Inducer
AMDE-1 is a potent autophagy inducer that activates the AMPK-mTORC1-ULK1 signaling pathway. While promoting autophagy, AMDE-1 also disrupts lysosomal function, thereby inhibiting autophagy-mediated degradation. This dual mechanism makes AMDE-1 a valuable tool for investigating autophagy-related processes in cancer research. -
Autophagy Inducer
Paroxetine hydrochloride hemihydrate is a selective serotonin reuptake inhibitor that also functions as an autophagy inducer. With an IC50 of 14 μM for GRK2 inhibition, it demonstrates potential in neuroprotective research and the study of mood disorders. This compound is suitable for investigations into its effects on cellular processes such as autophagy, neurobiology, and therapeutic applications for depression. -
Autophagy Inducer
20-Deoxyingenol is a diterpene compound identified from the roots of Euphorbia kansui, known for its role as an autophagy inducer. This compound promotes autophagy and lysosomal biogenesis by facilitating the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol is valuable for research into osteoarthritis (OA) and other conditions related to autophagy modulation. -
Autophagy Inducer
Asperphenamate is an autophagy inducer derived from the fungal metabolite Aspergillus flatiipes, known for its anti-cancer properties. It demonstrates potent cytotoxic effects, with IC50 values of 92.3 μM in T47D cells, 96.5 μM in MDA-MB-231 cells, and 97.9 μM in HL-60 cells. This compound is valuable in cancer research for exploring autophagy modulation and evaluating therapeutic strategies targeting tumor cell survival. -
mTOR Inhibitor/Autophagy Inducer
mTOR inhibitor-8 is a potent inhibitor of the mechanistic target of rapamycin (mTOR), functioning through the interaction with FKBP12. This compound effectively suppresses mTOR activity and induces autophagy in A549 human lung cancer cells. It is a valuable tool for studying mTOR signaling pathways and the role of autophagy in cancer research. -
Autophagy Inducer
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide that serves as an autophagy inducer. This compound promotes cellular autophagy processes, making it a valuable tool in cancer research. Additionally, C16 PEG2000 Ceramide can be utilized as a lipid carrier for targeted delivery of therapeutic agents in various experimental applications. -
Autophagy Inducer
Autophagy Inducer 3 is an agent that promotes autophagy through the induction of lethal autophagic processes. It has been shown to effectively induce autophagic cell death in various cancer cell lines while sparing normal cells. The compound triggers the formation of characteristic autophagic vacuoles and LC3 puncta, along with the upregulation of key autophagy-related markers such as Beclin and members of the Atg protein family, making it valuable for research in cancer biology and autophagy modulation. -
Autophagy Enhancer
AUTEN-67 is an orally active autophagy enhancer that also functions as an inhibitor of MTMR14. This compound exhibits significant anti-aging and neuroprotective properties, effectively protecting neurons from stress-induced cell death. Additionally, AUTEN-67 has been shown to restore nesting behavior in mouse models of Alzheimer’s disease, making it a valuable tool for researchers studying neurodegenerative disorders and autophagy modulation.
