(1R)-cis-Bifenthrin is a synthetic pyrethroid that targets autophagy pathways, particularly affecting motor coordination. Research indicates that (1R)-cis-Bifenthrin exposure leads to decreased motor function in ParKin-/- mice, evidenced by prolonged pole climbing times and reduced wheel running activity. The compound significantly decreases the number of tyrosine hydroxylase-positive cells and alters protein expression levels. Notably, (1R)-cis-Bifenthrin promotes the expression of mitophagy-related proteins, including LC3B and p62, while demonstrating enhanced binding affinity for transferrin and transferrin receptor 2. These interactions underscore its role in mitophagy and ferroptosis-related signaling pathways.
(1R)-cis-Bifenthrin is a synthetic pyrethroid that targets autophagy pathways, particularly affecting motor coordination. Research indicates that (1R)-cis-Bifenthrin exposure leads to decreased motor function in ParKin-/- mice, evidenced by prolonged pole climbing times and reduced wheel running activity. The compound significantly decreases the number of tyrosine hydroxylase-positive cells and alters protein expression levels. Notably, (1R)-cis-Bifenthrin promotes the expression of mitophagy-related proteins, including LC3B and p62, while demonstrating enhanced binding affinity for transferrin and transferrin receptor 2. These interactions underscore its role in mitophagy and ferroptosis-related signaling pathways.
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