SMER10 is a small-molecule autophagy inducer that enhances the formation of autophagosomes. This compound promotes the conversion of LC3-I to the autophagosome-associated form, LC3-II, thereby increasing the number of EGFP-LC3 positive structures in COS-7 and HeLa cells. SMER10 has been shown to facilitate the degradation of autophagic substrates such as the mutant huntingtin protein (EGFP-HDQ74) linked to Huntington's disease and A53T α-synuclein associated with Parkinson's disease, demonstrating its neuroprotective properties in relevant cellular models.
SMER10 is a small-molecule autophagy inducer that enhances the formation of autophagosomes. This compound promotes the conversion of LC3-I to the autophagosome-associated form, LC3-II, thereby increasing the number of EGFP-LC3 positive structures in COS-7 and HeLa cells. SMER10 has been shown to facilitate the degradation of autophagic substrates such as the mutant huntingtin protein (EGFP-HDQ74) linked to Huntington's disease and A53T α-synuclein associated with Parkinson's disease, demonstrating its neuroprotective properties in relevant cellular models.
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