Pemetrexed disodium heptahydrate is an innovative antifolate that serves as an autophagy inducer. It effectively inhibits key enzymes including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with Ki values of 1.3, 7.2, and 65 nM, respectively. This compound is valuable in research applications targeting metabolic pathways and autophagic processes in cancer and other diseases.
Pemetrexed disodium heptahydrate is an innovative antifolate that serves as an autophagy inducer. It effectively inhibits key enzymes including thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), with Ki values of 1.3, 7.2, and 65 nM, respectively. This compound is valuable in research applications targeting metabolic pathways and autophagic processes in cancer and other diseases.
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