AZD1208

Catalog No.: A13203

pan-Pim kinase inhibitor

AZD1208

AZD1208 Chemical Structure

CAS NO. 1204144-28-4

AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.

Availability: In stock

Package Price Qty
5 mg
$70.00
10 mg
$100.00
25 mg
$200.00
50 mg
$350.00
10mM * 1mL in DMSO
$75.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Remy J, .et al. Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis, Biochim Biophys Acta Mol Cell Res, 2019, Feb;1866(2):175-189 PMID: 30389373
  • Andrea L. Casillas, .et al. Hypoxia-inducible PIM kinase expression promotes resistance to anti-angiogenic agents, Clin Cancer Res, 2018, Jan 1; 24(1): 169-180 PMID: 29084916
  • Jin H. Song, .et al. Mechanisms Behind Resistance to PI3K Inhibitor Treatment Induced by the PIM Kinase, Mol Cancer Ther, 2018, Dec;17(12):2710-2721 PMID: 30190422
  • Sathish K.R. Padi, .et al. Targeting the PIM protein kinases for the treatment of a T-cell acute lymphoblastic leukemia subset, Oncotarget, 2017, May 2; 8(18): 30199-30216 PMID: 28415816
  • Lim R, .et al. Inhibition of PIM1 kinase attenuates inflammation-induced pro-labour mediators in human foetal membranes in vitro, Mol Hum Reprod, 2017, Jun 1;23(6):428-440 PMID: 28333279

Biological Activity

AZD1208 is orally available, small molecule inhibitor of PIM kinases with potential antineoplastic activity.
Targets
Pim1 (Cell-free assay) Pim3 (Cell-free assay) Pim2 (Cell-free assay)
0.4 nM1.9 nM5 nM
In vitro DMSO Warmed: 70 mg/mL (184.45 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.35 mL 131.76 mL 263.52 mL
0.5 mM 5.27 mL 26.35 mL 52.7 mL
1 mM 2.64 mL 13.18 mL 26.35 mL
5 mM 0.53 mL 2.64 mL 5.27 mL

*The above data is based on the productmolecular weight 379.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13203
Actions Inhibitor
CAS No. 1204144-28-4
Formula C21H21N3O2S
M. Wt 379.48
Solubility DMSO
Purity >98%
Synonyms AZD 1208, AZD-1208
SMILES C1C[[email protected]](CN(C1)C2=C(C=CC=C2/C=C\3/C(=O)NC(=O)S3)C4=CC=CC=C4)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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