Azidamfenicol is a chloramphenicol-like antibiotic that functions by inhibiting ribosomal peptidyltransferase with a Ki value of 22 μM. This broad-spectrum agent exhibits significant antibacterial activity, making it useful in studying bacterial protein synthesis. Additionally, Azidamfenicol serves as a click chemistry reagent due to the presence of an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, DBCO, or BCN groups. This dual functionality allows for versatile applications in chemical biology and bioconjugation strategies.
Azidamfenicol is a chloramphenicol-like antibiotic that functions by inhibiting ribosomal peptidyltransferase with a Ki value of 22 μM. This broad-spectrum agent exhibits significant antibacterial activity, making it useful in studying bacterial protein synthesis. Additionally, Azidamfenicol serves as a click chemistry reagent due to the presence of an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, DBCO, or BCN groups. This dual functionality allows for versatile applications in chemical biology and bioconjugation strategies.
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