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BI-847325

MEK/Aurora Inhibitor

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Catalog No. A15762

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
BI-847325 5mg A15762-5

Regular Price: €99.75

Special Price: €89.78

BI-847325 10mg A15762-10

Regular Price: €171.00

Special Price: €153.90

BI-847325 25mg A15762-25

Regular Price: €342.00

Special Price: €307.80

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

BI-847325

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Chemical Information

Catalog Num A15762
Actions Inhibitor
M. Wt 464.56
Formula C29H28N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1207293-36-4
Synonyms BI 847325, BI847325
SMILES code CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O
Chemical Name (Z)-3-(3-((4-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide

Biological Activity

Description
 BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Targets
Aurora B (Xenopus laevis) MEK2 Aurora C (Human) Aurora A (Human) MEK1
3 nM4 nM15 nM25 nM25 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.53 mL 107.63 mL 215.26mL
0.5 mM 4.31 mL 21.53 mL 43.05 mL
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL

*The above data is based on the productmolecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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