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$0.00 - Hilda Samimi, .et al. Transcript-level regulation of MALAT1-mediated cell cycle and apoptosis genes using dual MEK/Aurora kinase inhibitor -BI-847325- on anaplastic thyroid carcinoma, DARU J Pharm Sci, 2019, 1-7
Biological Activity
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Targets
| Aurora B (Xenopus laevis) | MEK2 | Aurora C (Human) | Aurora A (Human) | MEK1 |
| 3 nM | 4 nM | 15 nM | 25 nM | 25 nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.53 mL | 107.63 mL | 215.26 mL |
| 0.5 mM | 4.31 mL | 21.53 mL | 43.05 mL |
| 1 mM | 2.15 mL | 10.76 mL | 21.53 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.31 mL |
*The above data is based on the productmolecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15762 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 464.56 |
| Formula | C29H28N4O2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1207293-36-4 |
| Synonyms | BI 847325, BI847325 |
| SMILES | CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O |
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