BI-847325

Catalog No.: A15762

MEK/Aurora Inhibitor

BI-847325

BI-847325 Chemical Structure

CAS NO. 1207293-36-4

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $105.00

Special Price $84.00

10 mg

Regular Price: $180.00

Special Price $144.00

25 mg

Regular Price: $360.00

Special Price $288.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
Targets
Aurora B (Xenopus laevis) MEK2 Aurora C (Human) Aurora A (Human) MEK1
3 nM4 nM15 nM25 nM25 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.53 mL 107.63 mL 215.26 mL
0.5 mM 4.31 mL 21.53 mL 43.05 mL
1 mM 2.15 mL 10.76 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL

*The above data is based on the productmolecular weight 464.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A15762
Actions Inhibitor
M. Wt 464.56
Formula C29H28N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1207293-36-4
Synonyms BI 847325, BI847325
SMILES CCNC(C#CC1=CC=C2C(NC(/C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC=CC=C4)=O)=C1)=O

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