Total item
Cart Subtotal
$0.00 - Van Sebille YZ, .et al. Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity, Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
- Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Biological Activity
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
Targets
| EGFR (L858R) (Cell-free assay) | EGFR (wt) (Cell-free assay) | EGFR (L858R/T790M) (Cell-free assay) | HER2 (Cell-free assay) | |
| 0.4 nM | 0.5 nM | 10 nM | 14 nM |
| In vitro (25°C) | DMSO | 97 mg/mL (199.61 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 15 mg/mL (30.86 mM) | ||
| In vivo | 0.5% methylcellulose/0.2% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.58 mL | 102.9 mL | 205.8 mL |
| 0.5 mM | 4.12 mL | 20.58 mL | 41.16 mL |
| 1 mM | 2.06 mL | 10.29 mL | 20.58 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10141 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 485.9 |
| Formula | C24H25ClFN5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 439081-18-2 |
| Synonyms | Tomtovok,Afatinib |
| SMILES | CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4 |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
You may also be interested in the following product(s)
Pelitinib (EKB-569)
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.
XL647 (Tesevatinib)
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major ro…
ASP8273 (Naquotinib)
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with po…
OSI-420
OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by…
SU-5402
SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor…
AEE788
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, …
WHI-P180
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
Erlotinib HCl
Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).
Keywords:buy BIBW2992 (Afatinib) | BIBW2992 (Afatinib) Supplier | purchase | cost | manufacturer | order | distributor | buy 439081-18-2| 439081-18-2 Supplier | purchase 439081-18-2 | 439081-18-2 cost | 439081-18-2 manufacturer | order 439081-18-2 | 439081-18-2 distributor
Adooq Quality Guarantee
We promise all products perform as described.