BIBW2992 (Afatinib)

Catalog No.: A10141

EGFR inhibitor

BIBW2992 (Afatinib) Chemical Structure

CAS NO. 439081-18-2

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$50.00
25 mg
$70.00
100 mg
$190.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
Targets
EGFR (L858R) (Cell-free assay) EGFR (wt) (Cell-free assay) EGFR (L858R/T790M) (Cell-free assay) HER2 (Cell-free assay)
0.4 nM0.5 nM10 nM14 nM
In vitro (25°C) DMSO 97 mg/mL (199.61 mM)
Water <1 mg/mL (<1 mM)
Ethanol 15 mg/mL (30.86 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.58 mL 102.9 mL 205.8 mL
0.5 mM 4.12 mL 20.58 mL 41.16 mL
1 mM 2.06 mL 10.29 mL 20.58 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10141
Actions Inhibitor
M. Wt 485.9
Formula C24H25ClFN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 439081-18-2
Synonyms Tomtovok,Afatinib
SMILES CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4

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