BIBW2992 (Afatinib)

Catalog No.: A10141

EGFR inhibitor

BIBW2992 (Afatinib)

BIBW2992 (Afatinib) Chemical Structure

CAS NO. 439081-18-2

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$50.00
25 mg
$70.00
100 mg
$190.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Van Sebille YZ, .et al. Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity, Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
  • Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
Targets
EGFR (L858R) (Cell-free assay) EGFR (wt) (Cell-free assay) EGFR (L858R/T790M) (Cell-free assay) HER2 (Cell-free assay)
0.4 nM0.5 nM10 nM14 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.58 mL 102.9 mL 205.8 mL
0.5 mM 4.12 mL 20.58 mL 41.16 mL
1 mM 2.06 mL 10.29 mL 20.58 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10141
Actions Inhibitor
CAS No. 439081-18-2
Formula C24H25ClFN5O3
M. Wt 485.9
Purity >98%
Synonyms Tomtovok,Afatinib
SMILES CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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