United States
You have no items in your shopping cart.
Publications citing Adooq Products
BIBW2992 (Afatinib) Citations (1)
- Fujita KI,et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 28479358
Chemical Information
| Catalog Num | A10141 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 485.9 |
| Formula | C24H25ClFN5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 439081-18-2 |
| Synonyms | Tomtovok,Afatinib |
| SMILES code | CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4 |
| Chemical Name | N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4(dimethylamino)-2-butenamide |
Description |
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. | ||||||||||
Targets |
|
||||||||||
| Solubility (25°C) * | In vitro | DMSO | 97 mg/mL (199.61 mM) |
|---|---|---|---|
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 15 mg/mL (30.86 mM) | ||
| In vivo | 0.5% methylcellulose/0.2% Tween 80 | 30 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.58 mL | 102.9 mL | 205.8mL |
| 0.5 mM | 4.12 mL | 20.58 mL | 41.16 mL |
| 1 mM | 2.06 mL | 10.29 mL | 20.58 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.12 mL |
*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|
Cat. No. | Product Name | Solubility(mg/mL) | ||
|---|---|---|---|---|
| Water | DMSO | Ethanol | ||
| A10043 | AEE788 | <1 mg/mL | 88 mg/mL | <1 mg/mL |
| A11022 | AG-1478 (Tyrphostin AG-1478) | <1 mg/mL | 25 mg/mL | 13 mg/mL |
| A10047 | AG 490 | <1 mg/mL | 59 mg/mL | 6 mg/mL |
| A11027 | ARRY-380 | <1 mg/mL | 114 mg/mL | <1 mg/mL |
| A11158 | ARRY334543 | <1 mg/mL | 6 mg/mL | <1 mg/mL |
| A11155 | AST-1306 | <1 mg/mL | 124 mg/mL | <1 mg/mL |
| A10116 | AZD8931 | <1 mg/mL | 40 mg/mL | <1 mg/mL |
| A11334 | BIBX 1382 | 50 mg/mL | 50 mg/mL | N/A |
| A11209 | Lenalidomide (CC-5013) | <1 mg/mL | 113 mg/mL | 20 mg/mL |
| A10743 | BMS 599626 (AC480) | <1 mg/mL | 55 mg/mL | <1 mg/mL |
| A10211 | Canertinib (CI-1033) | <1 mg/mL | 2 mg/mL | 9 mg/mL |
| A10210 | Chrysophanic acid (Chrysophanol) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| A10242 | CP-724714 | <1 mg/mL | 94 mg/mL | 94 mg/mL |
| A10362 | Erlotinib hydrochloride | <1 mg/mL | 3 mg/mL | <1 mg/mL |
| A10422 | Gefitinib (Iressa) | <1 mg/mL | 89 mg/mL | 4 mg/mL |
| A10514 | Lapatinib Ditosylate | <1 mg/mL | 185 mg/mL | <1 mg/mL |
| A10612 | Mubritinib (TAK 165) | 13 mg/mL | <1 mg/mL | <1 mg/mL |
| A10638 | Neratinib (HKI-272) | 2 mg/mL | <1 mg/mL | <1 mg/mL |
| A10678 | OSI-420 | 83 mg/mL | 2 mg/mL | <1 mg/mL |
| A10702 | PD153035 (HCl salt) | <1 mg/mL | <1 mg/mL | <1 mg/mL |
| A10706 | Pelitinib (EKB-569) | <1 mg/mL | 13 mg/mL | <1 mg/mL |
| A11051 | PF299804 | <1 mg/mL | 19 mg/mL | <1 mg/mL |
| A11236 | TAK-285 | <1 mg/mL | 110 mg/mL | 54 mg/mL |
| A10053 | Tyrphostin AG 879 | 36 mg/mLtd | <1 mg/mL | 3 mg/mL |
| A10990 | WZ3146 | <1 mg/mL | 93 mg/mL | <1 mg/mL |
| A10991 | WZ4002 | 13 mg/mL | <1 mg/mL | <1 mg/mL |
| A10992 | WZ8040 | 96 mg/mL | <1 mg/mL | 3 mg/mL |
Ordering online
To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.
To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.
When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards. We will then liaise with you or your purchasing department to confirm the order.
Found your products but not ready to order?
Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.
Ordering offline
You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order. Our contact details are:
- Tel: 866-930-6790
- Fax: 323-606-8156
- Email: [email protected]
We require the following information to process your order:
- The catalog number for each product.
- Your email address or fax number.
- Your name and telephone number.
- Shipping address and billing address.
- Purchase order numbers.
Similar product(s)
Special Price Starting at:
$63.00
Pelitinib (EKB-569) is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. ...
Special Price Starting at: $63.00
Special Price Starting at:
$150.00
XL647 is an orally bioavailable small-molecule RTK inhibitor that binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, i ...
Special Price Starting at: $150.00
Special Price Starting at:
$180.00
ASP8273 is an orally available, irreversible, third-generation, mutant-selective, epidermal growth factor receptor (EGFR) inhibitor, with potential antineoplastic activity. ...
Special Price Starting at: $180.00
Special Price Starting at:
$99.00
OSI-420 (Desmethyl Erlotinib,CP-473420) is an orally active EGFR tyrosin kinase inhibitor, which inhibits receptor tyrosine kinases (TKs) by inhibition of the intercellular domain . ...
Special Price Starting at: $99.00
Special Price Starting at:
$54.00
SU-5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, ...
Special Price Starting at: $54.00
Special Price Starting at:
$81.00
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2. ...
Special Price Starting at: $81.00
Special Price Starting at:
$150.00
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively. ...
Special Price Starting at: $150.00
Special Price Starting at:
$36.00
Erlotinib hydrochloride is a reversible tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR). ...
Special Price Starting at: $36.00
Special Price Starting at:
$63.00
Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1. ...
Special Price Starting at: $63.00
Special Price Starting at:
$72.00
BMS 599626 is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50=22, 32 and 190 nM, respectively) with potential antineoplastic activity. ...
Special Price Starting at: $72.00
Special Price Starting at:
$45.00
AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. ...
Special Price Starting at: $45.00
Special Price Starting at:
$70.00
WZ4002 is EGFR inhibitor against EGFR T790M (mutation of the gatekeeper T790 residue) which is detected in 50% of clinically resistant patients to gefitinib or erlotinib. ...
Special Price Starting at: $70.00
Special Price Starting at:
$180.00
TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB). TAK-285 has inhibitory activity against HER2 and EGFR kinases with IC50 valu ...
Special Price Starting at: $180.00
Special Price Starting at:
$120.00
PD158780 is a very potent inhibitor of EGFR with IC50 of 0.08 nM; pan-specific antagonist of ErbB receptor. ...
Special Price Starting at: $120.00
Special Price Starting at:
$50.00
PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR. ...
Special Price Starting at: $50.00
Special Price Starting at:
$45.00
CO-1686 is a novel, oral, targeted covalent (irreversible) inhibitor of the cancer-causing mutant forms of epidermal growth factor receptor (EGFR) currently being studied for the treatment of non-smal ...
Special Price Starting at: $45.00
Special Price Starting at:
$45.00
Neratinib (HKI-272) is a tyrosine kinase inhibitor. ...
Special Price Starting at: $45.00
Special Price Starting at:
$36.00
Mubritinib (TAK 165) is a potent EGFR and p34cdc2 inhibitor with IC50 of 6 nM and 0.2 µM, respectively. Mubritinib(TAK 165) also inhibits p33cdk2 and p33cdk5. ...
Special Price Starting at: $36.00
Special Price Starting at:
$120.00
CL-387785 is an irreversible inhibitor of EGFR with IC50 of 370+/-120 pM; is able to overcome resistance caused by the T790M mutation on a functional level. ...
Special Price Starting at: $120.00
Special Price Starting at:
$70.00
WZ8040 is a novel EGFR inhibitors that suppress the growth of EGFR-T790M-containing cell lines and inhibit EGFR phosphorylation. ...
Special Price Starting at: $70.00
Special Price Starting at:
$180.00
PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent ...
Special Price Starting at: $180.00
Special Price Starting at:
$81.00
PF299804 is a potent, orally available, irreversible inhibitor of tyrosine kinase human epidermal growth factor receptors (HER) 1 (EGFR), HER2, and HER4. ...
Special Price Starting at: $81.00
Special Price Starting at:
$80.00
AZD3759 is an orally available inhibitor of the epidermal growth factor receptor (EGFR). It binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. ...
Special Price Starting at: $80.00
Special Price Starting at:
$36.00
AG-1478 (Tyrphostin AG-1478) is an inhibitor of EGFR kinase with an IC50 value of 3 nM. ...
Special Price Starting at: $36.00
Special Price Starting at:
$50.00
AG-17 is an inhibitor of EGF receptor kinase with an IC50 value of 460 µM in the human epidermoid carcinoma cell line A431. ...
Special Price Starting at: $50.00
Special Price Starting at:
$60.00
AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of t ...
Special Price Starting at: $60.00
Special Price Starting at:
$157.00
CNX-2006 is a potent, mutant-selective EGFR inhibitor with excellent in vitro activity in cells with activating EGFR mutations, as well as in cells harbouring the T790M mutation. CNX-2006 is the proto ...
Special Price Starting at: $157.00
Special Price Starting at:
$36.00
Gefitinib is an EGFR inhibitor, which interrupts signaling through the epidermal growth factor receptor (EGFR) in target cells. ...
Special Price Starting at: $36.00
Special Price Starting at:
$27.00
Lapatinib is a dual tyrosine kinase inhibitor which interrupts the HER2 growth receptor pathway. ...
Special Price Starting at: $27.00
Special Price Starting at:
$54.00
CP-724714 is an orally available, small molecule, potent HER-2 tyrosine kinase inhibitor that inhibits HER2 kinase (IC50 3.8 ng/ml) . ...
Special Price Starting at: $54.00
Keywords:buy BIBW2992 (Afatinib) | BIBW2992 (Afatinib) Supplier | purchase BIBW2992 (Afatinib) | BIBW2992 (Afatinib) cost | BIBW2992 (Afatinib) manufacturer | order BIBW2992 (Afatinib) | BIBW2992 (Afatinib) distributor | buy 439081-18-2| 439081-18-2 Supplier | purchase 439081-18-2 | 439081-18-2 cost | 439081-18-2 manufacturer | order 439081-18-2 | 439081-18-2 distributor
We Using Safe Payments:
