(E/Z)-BIBW2992 (E/Z-Afatinib)

Name: (E/Z)-BIBW2992 (E/Z-Afatinib)
Brand: Adooq Bioscience
SKU: A10141
Rating: 5 (6 reviews)

Catalog No.: A10141

EGFR inhibitor

Adooq's (E/Z)-BIBW2992 (E/Z-Afatinib) has been cited by 6 publications

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

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(E/Z)-BIBW2992 (E/Z-Afatinib) 439081-18-2 EGFR inhibitor

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Grouped product items
Size	Price	Stock
100mg	$20.00	In stock
200mg	$30.00	In stock
500mg	$40.00	In stock
1g	$55.00	In stock
*10mM 1mL in DMSO**	$20.00	In stock
Bulk Size	Bulk Discount

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Research use only. We do not sell to patients.

Data Sheet SDS

Other Forms of (E/Z)-BIBW2992 (E/Z-Afatinib)

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Adooq Products cited in reputable paper

Adooq's (E/Z)-BIBW2992 (E/Z-Afatinib) has been cited by 6 publications

Song Han, .et al. , Neoplasia, 2025, Jan:59:101070 PMID: 39541736
Sang-Hyun Lee, .et al. , NPJ Precis Oncol, 2024, May 21;8(1):111 PMID: 38773241
Yi-Ru Pan, .et al. , Int J Biol Sci, 2023, May 21;19(9):2772-2786 PMID: 37324940
Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
Van Sebille YZ, .et al. , Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

Description

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A10141
Formula	C24H25ClFN5O3
Molecular Weight	485.9
CAS Number	439081-18-2
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
Synonyms	Tomtovok
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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