BIBW2992 (Afatinib)

Name: BIBW2992 (Afatinib)
Brand: Adooq Bioscience
SKU: A10141
Rating: 100 (2 reviews)

Catalog No.: A10141

EGFR inhibitor

Product Citations (2)

BIBW2992 (Afatinib) Chemical Structure

CAS NO. 439081-18-2

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

Availability: In stock

Package	Price	Qty
5 mg	$40.00
10 mg	$50.00
25 mg	$70.00
100 mg	$190.00
10mM * 1mL in DMSO	$50.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq BIBW2992 (Afatinib)

Van Sebille YZ, .et al. Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity, Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

Biological Activity

BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.

Targets

EGFR (L858R) (Cell-free assay)	EGFR (wt) (Cell-free assay)	EGFR (L858R/T790M) (Cell-free assay)	HER2 (Cell-free assay)
0.4 nM	0.5 nM	10 nM	14 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.58 mL	102.9 mL	205.8 mL
0.5 mM	4.12 mL	20.58 mL	41.16 mL
1 mM	2.06 mL	10.29 mL	20.58 mL
5 mM	0.41 mL	2.06 mL	4.12 mL

*The above data is based on the productmolecular weight 485.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10141
Actions	Inhibitor
CAS No.	439081-18-2
Formula	C24H25ClFN5O3
M. Wt	485.9
Solubility	DMSO
Purity	>98%
Synonyms	Tomtovok,Afatinib
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.