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(E/Z)-BIBW2992 (E/Z-Afatinib)

Catalog No.: A10141
EGFR inhibitor
Adooq's (E/Z)-BIBW2992 (E/Z-Afatinib) has been cited by 5 publications
BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
(E/Z)-BIBW2992 (E/Z-Afatinib)
Grouped product items
Product Name Price Stock Qty
BIBW2992 5mg
$40.00
In stock
BIBW2992 10mg
$50.00
In stock
BIBW2992 25mg
$70.00
In stock
BIBW2992 100mg
$190.00
In stock
BIBW2992 (Afatinib) 10mM * 1mL in DMSO
$50.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's (E/Z)-BIBW2992 (E/Z-Afatinib) has been cited by 5 publications
  • Sang-Hyun Lee, .et al. , NPJ Precis Oncol, 2024, May 21;8(1):111 PMID: 38773241
  • Yi-Ru Pan, .et al. , Int J Biol Sci, 2023, May 21;19(9):2772-2786 PMID: 37324940
  • Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
  • Van Sebille YZ, .et al. , Exp Biol Med (Maywood), 2019, Jun 11:1535370219855334 PMID: 31184924
  • Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
    • Biological Activity
    Discription BIBW2992 (Afatinib) is tyrosine kinase inhibitor (TKI) that irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases.
    Targets
    Target Value
    Product Information
    Catalog Num A10141
    Formula C24H25ClFN5O3
    Molecular Weight 485.9
    CAS Number 439081-18-2
    SMILES CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
    Synonyms Tomtovok
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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    Protein Tyrosine Kinases > EGFR/HER2
    Angiogenesis > EGFR/HER2
    JAK/Stat > EGFR/HER2
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