Afatinib

Catalog No.: A18014

EGFR inhibitor

Afatinib

Afatinib Chemical Structure

CAS NO. 850140-72-6

Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.

Availability: In stock

Package Price Qty
10 mg
$54.00
25 mg
$108.00
50 mg
$186.00
100 mg
$318.00
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Biological Activity

Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.58 mL 102.89 mL 205.79 mL
0.5 mM 4.12 mL 20.58 mL 41.16 mL
1 mM 2.06 mL 10.29 mL 20.58 mL
5 mM 0.41 mL 2.06 mL 4.12 mL

*The above data is based on the productmolecular weight 485.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18014
Actions Inhibitor
M. Wt 485.94
Formula C24H25ClFN5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 850140-72-6
Synonyms BIBW 2992, BIBW-2992, BIBW2992
SMILES O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[[email protected]@H]4COCC4)/C=C/CN(C)C

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