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Biological Activity
Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
Targets
| EGFR (L858R) | EGFR (wt) | EGFR (L858R/T790M) | HER2 | |
| 0.4 nM | 0.5 nM | 10 nM | 14 nM |
| In vitro (25°C) | DMSO | 87 mg/mL (121.3 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+30% PEG 300+ddH2O | 26 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.93 mL | 69.63 mL | 139.26 mL |
| 0.5 mM | 2.79 mL | 13.93 mL | 27.85 mL |
| 1 mM | 1.39 mL | 6.96 mL | 13.93 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.79 mL |
*The above data is based on the productmolecular weight 718.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14985 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 850140-73-7 |
| Formula | C32H33ClFN5O11 |
| M. Wt | 718.08 |
| Purity | >98% |
| Synonyms | BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib |
| SMILES | CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
United StatesAdooq Bioscience
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