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Afatinib dimaleate

Catalog No.: A14985

EGFR inhibitor

Afatinib dimaleate

Afatinib dimaleate Chemical Structure

CAS NO. 850140-73-7

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

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Biological Activity

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.
EGFR (L858R) EGFR (wt) EGFR (L858R/T790M) HER2
0.4 nM0.5 nM10 nM14 nM
In vitro (25°C) DMSO 87 mg/mL (121.3 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+30% PEG 300+ddH2O 26 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 13.93 mL 69.63 mL 139.26 mL
0.5 mM 2.79 mL 13.93 mL 27.85 mL
1 mM 1.39 mL 6.96 mL 13.93 mL
5 mM 0.28 mL 1.39 mL 2.79 mL

*The above data is based on the productmolecular weight 718.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14985
Actions Inhibitor
CAS No. 850140-73-7
Formula C32H33ClFN5O11
M. Wt 718.08
Purity >98%
Synonyms BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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