Afatinib dimaleate

Name: Afatinib dimaleate
SKU: A14985
Price: 60 USD
Rating: 5 (288 reviews)

Catalog No.: A14985

EGFR inhibitor

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

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Grouped product items
Product Name	Price	Stock
Afatinib dimaleate 25mg	Special Price $60.00 Regular Price $75.00	In stock
Afatinib dimaleate 50mg	Special Price $88.00 Regular Price $110.00	In stock
Afatinib dimaleate 100mg	Special Price $120.00 Regular Price $150.00	In stock
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Data Sheet

SDS

Other Forms of Afatinib dimaleate

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Biological Activity

Discription

Afatinib is an irreversible EGFR/HER2 inhibitor with an IC50 of 14 nM for in vitro potency against HER2.

Targets

Target	Value

Product Information

Catalog Num	A14985
Formula	C32H33ClFN5O11
Molecular Weight	718.08
CAS Number	850140-73-7
SMILES	CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4.C(=CC(=O)O)C(=O)O.C(=CC(=O)O)C(=O)O
Synonyms	BIBW 2992MA2, BIBW-2992, BIBW2992, BIBW 2992, Afatinib
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	87 mg/mL (121.3 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+30% PEG 300+ddH2O	26 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.63 mL	139.26 mL
0.5 mM	2.79 mL	13.93 mL	27.85 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂