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$0.00 - Qian Chu, .et al. Patulin induces pyroptosis through the autophagic-inflammasomal pathway in liver, Food Chem Toxicol, 2021, Jan;147:111867 PMID: 33217525
- Ye Tao, .et al. Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis, Chemosphere, 2019, 2019
- Ming Sun, .et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells, J Agric Food Chem, 2018, Nov 21;66(46):12376-12384 PMID: 30392375
- Xueyan Wu, .et al. Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells, Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546
Biological Activity
CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Targets
| In vitro | DMSO | 77 mg/mL (193.72 mM) | |
| Water | 77 mg/mL (193.72 mM) | ||
| Ethanol | 6 mg/mL (15.09 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.16 mL | 125.79 mL | 251.57 mL |
| 0.5 mM | 5.03 mL | 25.16 mL | 50.31 mL |
| 1 mM | 2.52 mL | 12.58 mL | 25.16 mL |
| 5 mM | 0.5 mL | 2.52 mL | 5.03 mL |
*The above data is based on the productmolecular weight 397.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13593 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 147859-80-1 |
| Formula | C19H31N3O6 |
| M. Wt | 397.5 |
| Purity | >98% |
| Synonyms | CA-074 Me |
| SMILES | CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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