CA-074 Methyl Ester

Catalog No.: A13593

Cathepsin B inhibitor

CA-074 Methyl Ester

CA-074 Methyl Ester Chemical Structure

CAS NO. 147859-80-1

CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$200.00
25 mg
$400.00
Custom Size Get quote

Free Overnight Delivery on orders over $500

Next day delivery by 10:00 a.m. Order now.

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Qian Chu, .et al. Patulin induces pyroptosis through the autophagic-inflammasomal pathway in liver, Food Chem Toxicol, 2021, Jan;147:111867 PMID: 33217525
  • Ye Tao, .et al. Autophagic-CTSB-inflammasome axis modulates hepatic stellate cells activation in arsenic-induced liver fibrosis, Chemosphere, 2019, 2019
  • Ming Sun, .et al. Patulin Induces Autophagy-Dependent Apoptosis through Lysosomal-Mitochondrial Axis and Impaired Mitophagy in HepG2 Cells, J Agric Food Chem, 2018, Nov 21;66(46):12376-12384 PMID: 30392375
  • Xueyan Wu, .et al. Mono(2-ethylhexyl) phthalate induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis in human endothelial cells, Food Chem Toxicol, 2017, Aug;106(Pt A):273-282 PMID: 28579546

Biological Activity

CA-074 methyl ester is a cell-permeable analog of CA-074 that acts as an irreversible cathepsin B inhibitor. CA-074 methyl ester is reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Targets
In vitro DMSO 77 mg/mL (193.72 mM)
Water 77 mg/mL (193.72 mM)
Ethanol 6 mg/mL (15.09 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.16 mL 125.79 mL 251.57 mL
0.5 mM 5.03 mL 25.16 mL 50.31 mL
1 mM 2.52 mL 12.58 mL 25.16 mL
5 mM 0.5 mL 2.52 mL 5.03 mL

*The above data is based on the productmolecular weight 397.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13593
Actions Inhibitor
CAS No. 147859-80-1
Formula C19H31N3O6
M. Wt 397.5
Solubility DMSO
Purity >98%
Synonyms CA-074 Me
SMILES CCCNC(=O)C1C(O1)C(=O)NC(C(C)CC)C(=O)N2CCCC2C(=O)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy CA-074 Methyl Ester | CA-074 Methyl Ester Supplier | purchase | cost | manufacturer | order | distributor | buy 147859-80-1| 147859-80-1 Supplier | purchase 147859-80-1 | 147859-80-1 cost | 147859-80-1 manufacturer | order 147859-80-1 | 147859-80-1 distributor
Rewards