AhR

AhR Agonist 6 is a potent agonist for the aryl hydrocarbon receptor (AhR), exhibiting an EC50 of 0.01 nM. This compound effectively activates AhR signaling pathways, making it valuable for investigating the receptor's role in toxicology, immune response, and cellular differentiation processes. Its high potency allows for precise modulation of AhR-related biological activities in various research applications.

3-OH-Kynurenamine is an aryl hydrocarbon receptor (AhR) activator that modulates immune responses. This compound enhances the expression of immune regulatory genes such as Ido1 and Tgfb1, demonstrating therapeutic potential in reducing skin inflammation in psoriasis mouse models, as well as alleviating kidney damage in nephrotoxic lupus mouse models. Its unique biological activity makes it valuable for research involving immune modulation and inflammatory diseases.

AhR agonist 7 is a potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 13 nM. This compound effectively activates AhR signaling pathways, making it valuable for research into toxicology, immunology, and cancer biology. AhR agonist 7 can be utilized to study the effects of AhR activation on gene expression and cellular responses.

L-Kynurenine sulfate is an aryl hydrocarbon receptor (AHR) agonist that promotes AHR-mediated signaling pathways. It has been shown to stimulate the polarization of naive T cells towards the anti-inflammatory regulatory T cell (Treg) phenotype, enhancing immune tolerance mechanisms. This compound is valuable for research focused on immunology, inflammation, and therapeutic approaches in autoimmune diseases.

AhR modulator-2 is an AHR activator with an EC50 of 0.028 μM in HepG2-Lucia cells. This compound is valuable for investigating the role of the aryl hydrocarbon receptor (AHR) in various diseases, including skin disorders and cancer. Its ability to modulate AHR activity makes it a useful tool in the study of AHR-mediated signaling pathways and associated pathologies.

Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist that functions at low picomolar concentrations. It is known to inhibit Hedgehog-induced osteoblast differentiation and Wnt3A-induced osteoblast differentiation in C3H10T1/2 cells. Additionally, Picoberin has the ability to upregulate genes responsible for encoding phase I and II metabolic enzymes, making it a valuable reagent for research into cellular differentiation and metabolic processes.

AHR Antagonist 6 is an aryl hydrocarbon receptor (AHR) antagonist that inhibits AHR signaling pathways. This compound has demonstrated key biological activity in modulating immune responses and is utilized in cancer research to investigate the role of AHR in tumor microenvironments. Researchers can employ AHR Antagonist 6 to explore therapeutic strategies targeting AHR-mediated pathways in various cancer models.

β-Naphthoflavone-CH2-Br is a ligand for the arylhydrocarbon receptor (AhR), involved in regulating various biological processes, including xenobiotic metabolism. This compound serves as a key intermediate for synthesizing the PROTAC β-NF-JQ1, facilitating targeted protein degradation research. Its role in modulating AhR activity makes it valuable for studies in toxicology, pharmacology, and cancer research.

Benzyl butyl phthalate is an aryl hydrocarbon receptor (AhR) activator that plays a significant role in cellular signaling. It has been shown to promote the migration and invasion of hemangioma (HA) cells through the upregulation of Zeb1. In breast cancer cells, Benzyl butyl phthalate activates the SPHK1/S1P/S1PR3 pathway, contributing to the formation of metastasis-initiating breast cancer stem cells (BCSCs). This compound is instrumental for research in cancer biology and cellular signaling.

AFP464 is a prodrug of Aminoflavone and an agonist of the aryl hydrocarbon receptor (AhR). It exhibits significant biological activity by downregulating α6-integrin expression, inhibiting breast tumor growth, and reducing the population of tumor-initiating cells. Additionally, AFP464 disrupts mammosphere structure, induces mucin lake cluster formation, triggers DNA damage, and demonstrates antiproliferative effects. This compound is suitable for research applications focused on breast cancer.

Dibenz[a,h]anthracene (DBA) acts as a potent agonist of the aryl hydrocarbon receptor (AhR) and is classified as a polycyclic aromatic hydrocarbon. It is known for its significant carcinogenic properties, inducing dose-dependent increases in DNA adduct formation and mutation frequency in lacZ assays. Additionally, DBA has been shown to upregulate the St3gal5 gene. This reagent is applicable in cancer research, particularly in studies examining mechanisms of carcinogenesis and the role of AhR signaling in tumor development.