Dibenz[a,h]anthracene (DBA) acts as a potent agonist of the aryl hydrocarbon receptor (AhR) and is classified as a polycyclic aromatic hydrocarbon. It is known for its significant carcinogenic properties, inducing dose-dependent increases in DNA adduct formation and mutation frequency in lacZ assays. Additionally, DBA has been shown to upregulate the St3gal5 gene. This reagent is applicable in cancer research, particularly in studies examining mechanisms of carcinogenesis and the role of AhR signaling in tumor development.
Dibenz[a,h]anthracene (DBA) acts as a potent agonist of the aryl hydrocarbon receptor (AhR) and is classified as a polycyclic aromatic hydrocarbon. It is known for its significant carcinogenic properties, inducing dose-dependent increases in DNA adduct formation and mutation frequency in lacZ assays. Additionally, DBA has been shown to upregulate the St3gal5 gene. This reagent is applicable in cancer research, particularly in studies examining mechanisms of carcinogenesis and the role of AhR signaling in tumor development.
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