Catalog No.
Product Name
Application
Product Information
Citations
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α-amylase Inhibitor
5-O-Coumaroylquinic acid is a potent, reversible, non-competitive inhibitor of α-amylase, exhibiting an IC50 value of 69.39 μM. This compound is valuable for research into diabetes, as it interacts with the enzyme involved in carbohydrate metabolism, potentially aiding in the development of therapeutic strategies for glycemic control. Its inhibition of α-amylase may provide insights into managing postprandial glucose levels. -
α-amylase Inhibitor
8,3′,4′-Trihydroxyflavone-7-O-β-D-glucopyranoside is a natural compound derived from Bidens bipinnata, acting as an α-amylase inhibitor. It exhibits a 22% inhibitory effect on α-amylase activity at a concentration of 0.556 mg/mL. This compound may be of interest for research in diabetes management and carbohydrate metabolism studies. -
Antioxidant
Luteolin 4'-O-β-D-glucuronopyranoside is a flavonoid glycoside with notable antioxidant properties. It is derived from the aerial parts of Cyperus rotundus and has been shown to inhibit α-amylase activity. This compound is relevant for research applications focused on oxidative stress and diabetes, highlighting its potential role in managing metabolic disorders. -
α-Amylase Inhibitor
α-Amylase-IN-5 is a potent inhibitor of α-amylase, demonstrating an IC50 value of 18.8 mM. This compound is primarily utilized in research focused on carbohydrate metabolism, obesity, and diabetes management. It serves as a valuable tool for investigating the role of α-amylase in digestive processes and can aid in the development of therapeutic strategies targeting carbohydrate absorption. -
α‑amylase Inhibitor
α-Amylase-IN-8 is a selective inhibitor of α-amylase, with an IC50 value of 58.1 μM. This compound is valuable for research focused on type 2 diabetes, where the modulation of carbohydrate metabolism is of interest. Its inhibition of α-amylase can help in the understanding of glucose absorption and the subsequent effects on blood sugar levels. -
α-Amylase Inhibitor
α-Amylase-IN-1 is a potent α-Amylase inhibitor with an IC50 value of 0.5509 μM, making it an effective tool for research in carbohydrate metabolism. Additionally, it exhibits antioxidant activity, demonstrating an IC50 value of 53.49 μM for scavenging DPPH free radicals. This compound is valuable for studies related to diabetes management and the effects of oxidative stress on cellular health. -
α-Amylase Inhibitor
3,5,6,7,8,4'-Hexamethoxyflavone is an α-Amylase inhibitor, demonstrating 28.3% inhibitory activity at a concentration of 500 μM. This compound is valuable in studying carbohydrate metabolism and has potential applications in diabetes research and obesity management. Its inhibitory properties make it suitable for investigating metabolic pathways and developing therapeutic strategies targeting α-Amylase. -
MAO Inhibitor
MAO-B-IN-46 is a selective inhibitor of human monoamine oxidase B (hMAO-B) with an IC50 of 26.8 nM, exhibiting weak inhibition of hMAO-A (IC50: 7.2054 μM). This compound also functions as an α-amylase inhibitor, presenting an IC50 of 19.46 μM. Its neuroprotective properties demonstrate the potential for investigating neurodegenerative conditions such as Parkinson's disease, while its ability to scavenge DPPH and ABTS free radicals (IC50 values of 17.86 μM and 17.71 μM, respectively) highlights its relevance in research related to oxidative stress and diabetes. MAO-B-IN-46 shows minimal toxicity to human gingival fibroblasts and SH-SY5Y cells. -
α-Amylase Inhibitor
α-Amylase-IN-9 is a potent α-Amylase inhibitor with an IC50 value of 14.64 μM. This compound is specifically designed for use in diabetes research, aiding in the exploration of glucose regulation and carbohydrate metabolism. Its inhibitory activity on α-Amylase makes it a valuable tool for studying potential therapeutic approaches to managing hyperglycemia and related metabolic disorders. -
HPA Inhibitor
HPA-IN-2 is a potent and selective inhibitor of human pancreatic α-amylase (HPA) with an IC50 value of 8.2 μM, demonstrating its efficacy in modulating carbohydrate digestion. In contrast, it shows significantly weaker inhibition of α-glucosidase with an IC50 of 450.7 μM. This compound is utilized in research focused on diabetes and metabolic disorders, particularly in understanding the regulation of carbohydrate metabolism. -
α-glucosidase/α-amylase Inhibitor
Sekikaic acid is a potent inhibitor of α-glucosidase and α-amylase, playing a significant role in the management of carbohydrate metabolism. Its biological activities include hypolipidemic and antioxidant effects, as well as antidiabetic properties, making it a valuable compound for research into metabolic disorders. Sekikaic acid has been shown to significantly reduce LDL cholesterol, total cholesterol, and triglyceride levels, while also promoting the regeneration of pancreatic beta cells. This compound is an essential tool for studies focused on diabetes and lipid metabolism. -
α-amylase Inhibitor
α-Amylase-IN-12 is a selective inhibitor of α-amylase, exhibiting a mixed inhibition mechanism with an IC50 value of 0.15 mM. It also demonstrates an IC50 of 9.40 mM against α-glucosidase. This compound promotes glucose uptake in yeast cells and shows notable antiglycation activity at elevated concentrations. α-Amylase-IN-12 is applicable in diabetes research, providing insights into carbohydrate metabolism and potential therapeutic strategies. -
α-Amylase Inhibitor
Onjisaponin R serves as a specific α-amylase inhibitor, pivotal in regulating carbohydrate metabolism. It demonstrates significant potential in diabetes research by modulating blood glucose levels and enhancing glycemic control. This compound is essential for studies exploring therapeutic strategies for diabetes management and related metabolic disorders. -
α-glucosidase/α-amylase Dual Inhibitor
2,7"-Phloroglucinol-6,6'-bieckol functions as a dual inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 6.94 μM and 23.35 μM, respectively. This compound has demonstrated the ability to mitigate postprandial hyperglycemia in diabetic mouse models. 2,7"-Phloroglucinol-6,6'-bieckol is valuable for research focused on diabetes and glucose metabolism. -
α-glucosidase/α-amylase enzyme Dual Inhibitor
α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease. -
α-Amylase Inhibitor
Quercetin 3-(6″-caffeoylsophoroside) is a potent α-amylase inhibitor with an IC50 of 73.66 μg/mL, demonstrating significant potential for antidiabetic applications. Isolated from the hydro-methanolic extract of Cardamine hirsuta Linn., this compound exerts its biological activity by reducing oxidative stress and inhibiting α-amylase. It is a valuable tool for researchers investigating the mechanisms and treatment strategies for diabetes mellitus. -
α-Amylase/α-Glucosidase Inhibitor
3,4,6-Tri-O-galloyl-D-glucose is a mixed-type inhibitor of α-amylase and α-glucosidase, with an IC50 of 334.6 μM against porcine α-amylase and 46.5 μM against yeast α-glucosidase. This compound demonstrates free radical scavenging capabilities, ferric-reducing power, and significant antioxidant activity. Its properties make it a valuable tool for research focused on diabetes and related metabolic disorders. -
Antidiabetic Agent
Antidiabetic Agent 5 is an inhibitor of α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 μM and 8.89 μM, respectively. This compound effectively reduces sugar levels in biological systems, making it a valuable tool for the study of type II diabetes. Antidiabetic Agent 5 offers potential insights into therapeutic strategies for managing glycemic control and advancing diabetes research. -
Sesquiterpene Gglycoside
Dendromoniliside D is a sesquiterpene glycoside that functions as an α-amylase inhibitor. Isolated from Dendrobium nobile, it exhibits significant potential in cancer research, particularly concerning liver, lung, and breast cancers. Its biological activity makes it a valuable compound for studies focused on metabolic regulation and cancer therapeutics. -
α-Amylase Inhibitor
α-Amylase-IN-13 is a selective inhibitor of α-amylase that operates via a mixed inhibition mechanism (IC50 = 0.71 μM). This brain-penetrant compound has demonstrated the ability to significantly lower blood glucose levels in diabetic rat models and promotes notable histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 is a valuable tool for investigating diabetic complications and evaluating therapeutic strategies for diabetes management. -
Triterpenoid Saponin
Ladyginoside A is a triterpenoid saponin derived from the leaves of Polyscias fruticosa. It exhibits inhibitory activity against α-amylase and α-glucosidase, making it relevant for the regulation of carbohydrate metabolism. Additionally, Ladyginoside A shows potential anti-inflammatory properties and may stabilize mast cells. This compound is suitable for investigations into inflammation and metabolic disorders, including diabetes. -
α-Amylase Inhibitor
Gibbestatin B is an α-amylase inhibitor that targets the expression of α-amylase induced by gibberellin in de-embryonated rice and barley, with an IC50 ranging from 25 to 50 ppm. Its specific action on α-amylase makes it a valuable tool in studying carbohydrate metabolism and plant physiological responses to gibberellin. Notably, Gibbestatin B exhibits no antibacterial, anti-yeast, or antifungal activity at concentrations of 100 ppm, allowing for focused research on its enzymatic inhibition. -
Component Of Phospholipids
Docosapentaenoic acid (22n-3) sodium is a key component of phospholipids, influencing cell membrane integrity and function. It exhibits inhibitory activity against α-amylase and α-glucosidase with IC50 values of 17 μg/mL and 22 μg/mL, respectively, contributing to its potential applications in metabolic research. Additionally, Docosapentaenoic acid (22n-3) sodium has been shown to enhance cell viability and demonstrates mild anti-inflammatory properties, making it useful for various biological studies. -
α-Amylase Inhibitor
α-Amylase-IN-10 is a potent inhibitor of α-amylase, exhibiting an IC50 value of 5.00 µM. This compound is valuable for research focusing on type 2 diabetes mellitus, providing insights into carbohydrate metabolism and potential therapeutic strategies. Its ability to modulate α-amylase activity makes it a useful tool in studies aimed at understanding metabolic disorders and developing anti-diabetic agents. -
α-Amylase Inhibitor
α-Amylase-IN-7 is a specific inhibitor of α-Amylase, exhibiting an IC50 value of 40 μM. This compound demonstrates potential as an antidiabetic agent by regulating carbohydrate metabolism. Research applications may include the study of glycemic control and the development of therapeutic strategies for diabetes management. -
Enzyme
β-Amylase from Bacillus subtilis is a starch-degrading enzyme that hydrolyzes α-1,4-glycosidic linkages in polysaccharides. This enzyme is instrumental in various biochemical assays and research applications, particularly in studies involving carbohydrate metabolism and enzymatic activity. Its robust activity makes it suitable for use in food processing, fermentation, and the development of biofuels. -
Cholinergic Agonist
Aclatonium napadisylate is a cholinergic agonist that enhances amylase release and facilitates Ca2+ efflux. This compound stimulates pancreatic exocrine secretion and promotes gastrointestinal motility and peristalsis. Aclatonium napadisylate is particularly relevant for research into gastrointestinal disorders and associated therapeutic approaches. -
Enzyme Substrate
Gal-G2-CNP serves as a substrate specifically for the quantitative determination of novel amylase and pancreatic amylase activities. This galactopyranosylmaltoside compound provides a valuable tool for enzyme characterization and kinetic studies, enhancing the understanding of carbohydrate metabolism. Its application is crucial in the study of digestive enzymes, facilitating advancements in biochemical and clinical research. -
Test Substrate
4-Nitrophenylmaltohexaoside is a chromogenic substrate specifically designed to target α-amylase. It exhibits key biological activity by producing a measurable chromogenic product upon enzymatic cleavage, facilitating the study of α-amylase activity. This reagent is widely applicable in enzymology research and can be utilized for high-throughput screening of α-amylase inhibitors and in the assessment of starch digestion. -
Pancreatic Digestive Enzymes
Pancreatin is an extract derived from porcine pancreas, enriched with key pancreatic digestive enzymes, including amylase, lipase, and protease. It facilitates the digestion of carbohydrates, fats, and proteins, making it essential for studying digestive processes and enzyme activity in various research applications. Pancreatin is commonly used in studies related to gastrointestinal disorders, enzyme replacement therapy, and metabolic research. -
Biochemical Assay Reagent
3,5-Dinitrosalicylic acid is a derivative of salicylic acid primarily used as a biochemical assay reagent. It serves as a colorimetric indicator for the quantification of reducing sugars and is essential in assays for α-amylase and other carbohydrases. This compound is widely utilized in carbohydrate chemistry and enzymatic activity studies, facilitating the analysis of reducing sugars in various samples. -
α-Amylase substrate
G3-CNP is a substrate for α-amylase, specifically designed to facilitate the monitoring of enzyme activity. Upon cleavage by α-amylase, G3-CNP generates 2-chloro-4-nitrophenol, which can be quantitatively measured at an absorbance of 405 nm. This compound serves as a valuable tool in enzymatic assays for the assessment of carbohydrate metabolism and related biochemical research applications. -
CCK antagonist
Proglumide sodium salt is a non-selective cholecystokinin (CCK) antagonist. It inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. -
glucosidase I/II inhibitor
Deoxynojirimycin is a Maltase-glucoamylase (a-glucosidase I and II) inhibitor. It interferes with N-linked glycosylation. -
Fatty Acid Synthase (FASN) Inhibitor
trans-Chalcone is an effective inhibitor of fatty acid synthase (FASN) and α-amylase, offering significant potential in metabolic research. Isolated from the skin of Aronia melanocarpa, this biphenolic compound induces cell cycle arrest and apoptosis in the MCF-7 breast cancer cell line, demonstrating its utility in cancer studies. Additionally, trans-Chalcone exhibits antifungal properties, making it applicable in studies of both cancer and microbial pathogenicity. -
DPP-4 Inhibitor
Antidiabetic agent 2 is a potent DPP-4 inhibitor that effectively promotes glucose uptake. This compound also inhibits PTP-1B, α-amylase, and α-glucosidase, exhibiting IC50 values of 0.036, 0.042, 0.241, and 0.185 μM, respectively. By decreasing blood glucose levels, Antidiabetic agent 2 serves as a valuable tool for research focused on diabetes management and the modulation of glucose homeostasis. -
α-Amylase Inhibitor
α-Amylase-IN-14 is a selective inhibitor of α-amylase, demonstrating robust interactions with the enzyme (-5.55 kcal/mol). This compound serves as a dual anti-inflammatory and anti-hyperglycemic agent, exhibiting significant radical scavenging activity against DPPH and ABTS radicals. α-Amylase-IN-14 is valuable for research focused on diabetes and related metabolic disorders. -
Detection Substrate
2-Chloro-4-nitrophenyl-β-D-maltotrioside is a chromogenic substrate that specifically targets α-amylase activity. It is utilized in bioluminescent and fluorescent assays, providing a valuable tool for the detection and quantification of α-amylase in various biological samples. This reagent is essential for studies involving carbohydrate metabolism and enzyme activity assays. -
Enzyme
Amylase is an enzyme primarily produced by the pancreas and salivary glands that catalyzes the hydrolysis of starch into simple sugars. It is classified into α, β, and γ subtypes, each playing a critical role in carbohydrate digestion. Amylase is widely used in biochemical research, food industry applications, and studies investigating carbohydrate metabolism disorders. -
α-glucosidase/α-amylase Inhibitor
2-Hydroxyquinoline is a selective inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 64.4 µg/mL and 130.5 µg/mL, respectively. This compound is valuable for investigating carbohydrate metabolism and can be utilized in research related to diabetes management and treatment strategies. Its inhibitory effects contribute to a deeper understanding of enzymatic roles in glucose absorption and metabolism. -
Volatile Compound
Dihydro-α-ionone is a volatile compound primarily derived from the essential oil of Persicaria hydropiper L. leaves. It exhibits notable inhibitory effects on α-glucosidase and α-amylase, making it a useful reagent in studies of carbohydrate metabolism. Its potential applications include the exploration of metabolic pathways and the development of therapeutic strategies for conditions such as diabetes.
