Catalog No.
Product Name
Application
Product Information
Citations
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α-glucosidase/α-amylase Inhibitor
Sekikaic acid is a potent inhibitor of α-glucosidase and α-amylase, playing a significant role in the management of carbohydrate metabolism. Its biological activities include hypolipidemic and antioxidant effects, as well as antidiabetic properties, making it a valuable compound for research into metabolic disorders. Sekikaic acid has been shown to significantly reduce LDL cholesterol, total cholesterol, and triglyceride levels, while also promoting the regeneration of pancreatic beta cells. This compound is an essential tool for studies focused on diabetes and lipid metabolism. -
α-amylase Inhibitor
α-Amylase-IN-12 is a selective inhibitor of α-amylase, exhibiting a mixed inhibition mechanism with an IC50 value of 0.15 mM. It also demonstrates an IC50 of 9.40 mM against α-glucosidase. This compound promotes glucose uptake in yeast cells and shows notable antiglycation activity at elevated concentrations. α-Amylase-IN-12 is applicable in diabetes research, providing insights into carbohydrate metabolism and potential therapeutic strategies. -
α-Amylase Inhibitor
Onjisaponin R serves as a specific α-amylase inhibitor, pivotal in regulating carbohydrate metabolism. It demonstrates significant potential in diabetes research by modulating blood glucose levels and enhancing glycemic control. This compound is essential for studies exploring therapeutic strategies for diabetes management and related metabolic disorders. -
α-glucosidase/α-amylase Dual Inhibitor
2,7"-Phloroglucinol-6,6'-bieckol functions as a dual inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 6.94 μM and 23.35 μM, respectively. This compound has demonstrated the ability to mitigate postprandial hyperglycemia in diabetic mouse models. 2,7"-Phloroglucinol-6,6'-bieckol is valuable for research focused on diabetes and glucose metabolism. -
α-glucosidase/α-amylase enzyme Dual Inhibitor
α-Amylase/α-Glucosidase-IN-7 is a competitive dual inhibitor targeting α-glucosidase and α-amylase, demonstrating IC50 values of 18.52 µM and 20.25 µM, respectively. Additionally, this compound effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 9.25 µM and 10.06 µM. α-Amylase/α-Glucosidase-IN-7 is valuable for research applications related to diabetes and Alzheimer’s disease. -
α-Amylase Inhibitor
Quercetin 3-(6″-caffeoylsophoroside) is a potent α-amylase inhibitor with an IC50 of 73.66 μg/mL, demonstrating significant potential for antidiabetic applications. Isolated from the hydro-methanolic extract of Cardamine hirsuta Linn., this compound exerts its biological activity by reducing oxidative stress and inhibiting α-amylase. It is a valuable tool for researchers investigating the mechanisms and treatment strategies for diabetes mellitus. -
α-Amylase/α-Glucosidase Inhibitor
3,4,6-Tri-O-galloyl-D-glucose is a mixed-type inhibitor of α-amylase and α-glucosidase, with an IC50 of 334.6 μM against porcine α-amylase and 46.5 μM against yeast α-glucosidase. This compound demonstrates free radical scavenging capabilities, ferric-reducing power, and significant antioxidant activity. Its properties make it a valuable tool for research focused on diabetes and related metabolic disorders. -
Antidiabetic Agent
Antidiabetic Agent 5 is an inhibitor of α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 μM and 8.89 μM, respectively. This compound effectively reduces sugar levels in biological systems, making it a valuable tool for the study of type II diabetes. Antidiabetic Agent 5 offers potential insights into therapeutic strategies for managing glycemic control and advancing diabetes research. -
Sesquiterpene Gglycoside
Dendromoniliside D is a sesquiterpene glycoside that functions as an α-amylase inhibitor. Isolated from Dendrobium nobile, it exhibits significant potential in cancer research, particularly concerning liver, lung, and breast cancers. Its biological activity makes it a valuable compound for studies focused on metabolic regulation and cancer therapeutics. -
α-Amylase Inhibitor
α-Amylase-IN-13 is a selective inhibitor of α-amylase that operates via a mixed inhibition mechanism (IC50 = 0.71 μM). This brain-penetrant compound has demonstrated the ability to significantly lower blood glucose levels in diabetic rat models and promotes notable histopathological improvements in the kidney, liver, and pancreas. α-Amylase-IN-13 is a valuable tool for investigating diabetic complications and evaluating therapeutic strategies for diabetes management. -
Triterpenoid Saponin
Ladyginoside A is a triterpenoid saponin derived from the leaves of Polyscias fruticosa. It exhibits inhibitory activity against α-amylase and α-glucosidase, making it relevant for the regulation of carbohydrate metabolism. Additionally, Ladyginoside A shows potential anti-inflammatory properties and may stabilize mast cells. This compound is suitable for investigations into inflammation and metabolic disorders, including diabetes. -
α-Amylase Inhibitor
Gibbestatin B is an α-amylase inhibitor that targets the expression of α-amylase induced by gibberellin in de-embryonated rice and barley, with an IC50 ranging from 25 to 50 ppm. Its specific action on α-amylase makes it a valuable tool in studying carbohydrate metabolism and plant physiological responses to gibberellin. Notably, Gibbestatin B exhibits no antibacterial, anti-yeast, or antifungal activity at concentrations of 100 ppm, allowing for focused research on its enzymatic inhibition. -
Component Of Phospholipids
Docosapentaenoic acid (22n-3) sodium is a key component of phospholipids, influencing cell membrane integrity and function. It exhibits inhibitory activity against α-amylase and α-glucosidase with IC50 values of 17 μg/mL and 22 μg/mL, respectively, contributing to its potential applications in metabolic research. Additionally, Docosapentaenoic acid (22n-3) sodium has been shown to enhance cell viability and demonstrates mild anti-inflammatory properties, making it useful for various biological studies. -
α-Amylase Inhibitor
α-Amylase-IN-10 is a potent inhibitor of α-amylase, exhibiting an IC50 value of 5.00 µM. This compound is valuable for research focusing on type 2 diabetes mellitus, providing insights into carbohydrate metabolism and potential therapeutic strategies. Its ability to modulate α-amylase activity makes it a useful tool in studies aimed at understanding metabolic disorders and developing anti-diabetic agents. -
α-Amylase Inhibitor
α-Amylase-IN-7 is a specific inhibitor of α-Amylase, exhibiting an IC50 value of 40 μM. This compound demonstrates potential as an antidiabetic agent by regulating carbohydrate metabolism. Research applications may include the study of glycemic control and the development of therapeutic strategies for diabetes management. -
Anticoagulant/Cancer Agent
Fucoidan is a biologically active polysaccharide that functions as an anticoagulant and exhibits antitumor properties. It effectively inhibits α-amylase and α-glucosidase, contributing to its potential applications in metabolic disorder research. Additionally, Fucoidan demonstrates antioxidant and antisteatotic activities, making it a valuable tool for studying various disease processes and therapeutic interventions. -
Tyrosinase Inhibitor
Kushenol A, a non-competitive inhibitor of tyrosinase, effectively blocks the conversion of L-tyrosine to L-DOPA, with IC50 and Ki values of 1.1 μM and 0.4 μM, respectively. Isolated from the root of Sophora flavescens, Kushenol A exhibits antioxidant properties and also inhibits alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase. This compound is valuable for research focused on skin whitening and anti-aging applications due to its enzyme inhibitory effects. -
Isoamylase
Isoamylase, also known as glycogen α-1,6-glucanohydrolase, catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin, and α/β-limit dextrins. This enzymatic activity is crucial for the degradation of complex carbohydrates, making Isoamylase valuable for research in carbohydrate metabolism, enzymology, and biotechnology applications. Its ability to selectively cleave α-1,6-glycosidic bonds allows for the detailed study of glycogen structure and function in various biological contexts. -
α-amylase/α-glucosidase/Acetylcholinesterase Inhibitor
Kaempferol-3,7-di-O-β-glucoside is a flavonol that acts as an inhibitor of α-amylase, α-glucosidase, and acetylcholinesterase. This compound has demonstrated protective effects on differentiating neuronal cells, specifically SH-SY5Y, against injury induced by Amyloid β peptide. Its enzyme inhibitory properties and neuroprotective effects indicate potential applications in Alzheimer's disease research and therapeutics. -
α-Glucosidase/α-Aamylase Inhibitor
Diphlorethohydroxycarmalol is a phlorotannin that serves as an inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 0.16 mM and 0.53 mM, respectively. This compound demonstrates significant anti-diabetic activity, making it relevant for research focused on glucose metabolism and diabetes management. Its mechanism of action highlights its potential application in developing therapeutic strategies for metabolic disorders. -
Hydrolase
Oligo-α-1,6-Glucosidase from Bacillus cereus ATCC7064 is a hydrolase enzyme that specifically targets and hydrolyzes oligosaccharides containing α-1,6-glycosidic bonds. This enzyme catalyzes the exo hydrolysis of α-1,6-glucoside linkages from nonreducing ends of substrates such as panose, palatinose, α-limit dextrins, and isomaltooligosaccharides. Oligo-α-1,6-Glucosidase plays a crucial role in the degradation of starch and glycogen, complementing the activity of α-amylase in the complete hydrolysis of amylopectin. Its applications include studies of carbohydrate metabolism and enzymatic processes involved in starch breakdown. -
α-Glucosidase Inhibitor
α-Amylase-IN-2 is an oleanolic acid oxime ester derivative that acts as a potent α-glucosidase inhibitor, exhibiting an IC50 value of 1.28 µM. Additionally, it demonstrates inhibitory activity against α-amylase with an IC50 of 3.8 µM. This compound is valuable for research applications focused on metabolic disorders such as diabetes, where modulation of carbohydrate digestion is critical. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-2 is a potent dual inhibitor of α-amylase and α-glucosidase, demonstrating IC50 values of 13.02 µM and 13.09 µM, respectively. This compound is primarily utilized in research investigating diabetic complications, offering significant insights into glucose metabolism and potential therapeutic strategies for managing diabetes. Its dual mechanism of action makes it a valuable tool for studying carbohydrate digestion and its implications in hyperglycemia. -
α-glucosidase Inhibitor
MDL-25637 is an α-glucosidase inhibitor that effectively inhibits the activity of enzymes such as sucrose, maltase, isomaltase, glucose amylase, and trehalose in the intestinal tract. This compound is primarily utilized in diabetes research to investigate the regulation of carbohydrate absorption and its implications for glucose homeostasis. Its ability to modulate enzymatic activity makes it a valuable tool for studying metabolic disorders associated with diabetes. -
α-Amylase/α-Glucosidase Inhibitor
α-Amylase/α-Glucosidase-IN-1 is a potent inhibitor of both α-amylase and α-glucosidase, exhibiting IC50 values of 2.01 µM and 2.09 µM, respectively. This compound is utilized in biochemical research to investigate mechanisms of glycemic control and has potential applications in the management of hyperglycemia. The inhibitory activity of α-Amylase/α-Glucosidase-IN-1 makes it a valuable tool for studying carbohydrate metabolism and related metabolic disorders. -
α-Glucosidase Inhibitor
α-Glucosidase-IN-3 is an oleanolic acid oxime ester derivative that acts as an inhibitor of α-glucosidase, exhibiting an IC50 value of 0.35 µM. This compound also demonstrates inhibitory activity against α-amylase, making it a valuable tool for studies focused on carbohydrate metabolism. Its potential applications include investigating the mechanisms of diabetes management and exploring the therapeutic effects of glycosidase inhibition in metabolic disorders. -
Endogenous Metabolite
A-57696 is a cholecystokinin (CCK) antagonist that selectively targets cortical CCK-B receptors with an IC50 of 25 nM. It functions as a competitive antagonist, effectively reversing CCK8-induced pancreatic alpha-amylase secretion and phosphatidylinositol degradation, while also inhibiting CCK8-induced gallbladder contraction. Notably, A-57696 exhibits partial agonist activity at CCK-B/gastrin receptors on NCI-H345 cells, eliciting up to 80% of the maximal CCK8 response. This compound serves as a valuable tool in research focused on gastrointestinal physiology and the modulation of CCK-related pathways. -
Flavonol
Kaempferol 3-O-alpha-L-(2, 3-di-Z-p-coumaroyl) rhamnoside is a flavonol compound derived from Platanus occidentalis. This compound exhibits significant inhibitory activity against alpha-amylase and DPP IV, making it suitable for research applications focused on carbohydrate metabolism and diabetes-related studies. Its unique structure and biological properties position it as a valuable tool in investigating the therapeutic potential of flavonoids in metabolic disorders. -
Stable Isotope
H-Abu-OH-d2 is a deuterium-labeled form of H-Abu-OH, one of the three isomers of aminobutyric acid. This compound serves as a stable isotope used in various biochemical studies and is particularly relevant in metabolic research. It has been observed to be elevated in the plasma of patients with conditions such as Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency, making it valuable for clinical investigations. -
Maltoamylase
Maltogenic amylase is an enzyme that targets maltoamylase, facilitating the hydrolysis of starch into shorter oligosaccharides. It exhibits significant biological activity in starch degradation and is instrumental in various biotechnological applications, including the food industry and biofuel production. Innovations in enzyme engineering enhance its reaction kinetics and substrate selectivity while allowing for activity modulation under varying pH conditions, enabling precise control in dynamic environments. -
Enzyme
β-Amylase from Bacillus subtilis is a starch-degrading enzyme that hydrolyzes α-1,4-glycosidic linkages in polysaccharides. This enzyme is instrumental in various biochemical assays and research applications, particularly in studies involving carbohydrate metabolism and enzymatic activity. Its robust activity makes it suitable for use in food processing, fermentation, and the development of biofuels. -
Cholinergic Agonist
Aclatonium napadisylate is a cholinergic agonist that enhances amylase release and facilitates Ca2+ efflux. This compound stimulates pancreatic exocrine secretion and promotes gastrointestinal motility and peristalsis. Aclatonium napadisylate is particularly relevant for research into gastrointestinal disorders and associated therapeutic approaches. -
Pancreatic Digestive Enzymes
Pancreatin is an extract derived from porcine pancreas, enriched with key pancreatic digestive enzymes, including amylase, lipase, and protease. It facilitates the digestion of carbohydrates, fats, and proteins, making it essential for studying digestive processes and enzyme activity in various research applications. Pancreatin is commonly used in studies related to gastrointestinal disorders, enzyme replacement therapy, and metabolic research. -
Biochemical Assay Reagent
3,5-Dinitrosalicylic acid is a derivative of salicylic acid primarily used as a biochemical assay reagent. It serves as a colorimetric indicator for the quantification of reducing sugars and is essential in assays for α-amylase and other carbohydrases. This compound is widely utilized in carbohydrate chemistry and enzymatic activity studies, facilitating the analysis of reducing sugars in various samples. -
α-Amylase substrate
G3-CNP is a substrate for α-amylase, specifically designed to facilitate the monitoring of enzyme activity. Upon cleavage by α-amylase, G3-CNP generates 2-chloro-4-nitrophenol, which can be quantitatively measured at an absorbance of 405 nm. This compound serves as a valuable tool in enzymatic assays for the assessment of carbohydrate metabolism and related biochemical research applications. -
Enzyme Substrate
Gal-G2-CNP serves as a substrate specifically for the quantitative determination of novel amylase and pancreatic amylase activities. This galactopyranosylmaltoside compound provides a valuable tool for enzyme characterization and kinetic studies, enhancing the understanding of carbohydrate metabolism. Its application is crucial in the study of digestive enzymes, facilitating advancements in biochemical and clinical research. -
Test Substrate
4-Nitrophenylmaltohexaoside is a chromogenic substrate specifically designed to target α-amylase. It exhibits key biological activity by producing a measurable chromogenic product upon enzymatic cleavage, facilitating the study of α-amylase activity. This reagent is widely applicable in enzymology research and can be utilized for high-throughput screening of α-amylase inhibitors and in the assessment of starch digestion. -
Detection Substrate
2-Chloro-4-nitrophenyl-β-D-maltotrioside is a chromogenic substrate that specifically targets α-amylase activity. It is utilized in bioluminescent and fluorescent assays, providing a valuable tool for the detection and quantification of α-amylase in various biological samples. This reagent is essential for studies involving carbohydrate metabolism and enzyme activity assays. -
Enzyme
Amylase is an enzyme primarily produced by the pancreas and salivary glands that catalyzes the hydrolysis of starch into simple sugars. It is classified into α, β, and γ subtypes, each playing a critical role in carbohydrate digestion. Amylase is widely used in biochemical research, food industry applications, and studies investigating carbohydrate metabolism disorders. -
α-glucosidase/α-amylase Inhibitor
2-Hydroxyquinoline is a selective inhibitor of α-glucosidase and α-amylase, exhibiting IC50 values of 64.4 µg/mL and 130.5 µg/mL, respectively. This compound is valuable for investigating carbohydrate metabolism and can be utilized in research related to diabetes management and treatment strategies. Its inhibitory effects contribute to a deeper understanding of enzymatic roles in glucose absorption and metabolism. -
Volatile Compound
Dihydro-α-ionone is a volatile compound primarily derived from the essential oil of Persicaria hydropiper L. leaves. It exhibits notable inhibitory effects on α-glucosidase and α-amylase, making it a useful reagent in studies of carbohydrate metabolism. Its potential applications include the exploration of metabolic pathways and the development of therapeutic strategies for conditions such as diabetes.
