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Clematomandshurica saponin B

Catalog No.: A64380
COX-2 Inhibitor
Clematomandshurica saponin B is a selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting significant inhibitory activity with an IC50 of 2.58 mM. This compound's ability to modulate COX-2 activity makes it valuable for studying inflammatory processes and analgesic pathways in various biological systems. It can serve as a tool for research applications focused on understanding pain mechanisms and developing anti-inflammatory therapies.
Clematomandshurica saponin B 916649-91-7 COX-2 Inhibitor
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Size Price Stock Qty
10mg
$565.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionClematomandshurica saponin B is a selective inhibitor of cyclooxygenase-2 (COX-2), exhibiting significant inhibitory activity with an IC50 of 2.58 mM. This compound's ability to modulate COX-2 activity makes it valuable for studying inflammatory processes and analgesic pathways in various biological systems. It can serve as a tool for research applications focused on understanding pain mechanisms and developing anti-inflammatory therapies.
Product Information
Catalog NumA64380
FormulaC92H142O46
Molecular Weight1984.08
CAS Number916649-91-7
SMILESOC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2[C@@H]([C@@H]([C@H]([C@@H](O2)C)O)O)O)O[C@H]1OC[C@H]([C@H]([C@@H]([C@H]3O)O)O)O[C@H]3OC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O[C@H]8[C@@H]([C@H]([C@H](CO8)O)O)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O[C@H]%10[C@@H]([C@@H]([C@@H](CO%10)O[C@@H]%11O[C@@H]([C@H]([C@@H]([C@H]%11O)O)O[C@H]%12[C@@H]([C@H]([C@@H]([C@H](O%12)CO[C@H]%13[C@@H]([C@@H]([C@H]([C@@H](O%13)C)O)O)O)O)O)OC(/C=C/C%14=CC(O)=C(C=C%14)OC)=O)CO)O)O)O)C)([H])CC%15)C)([H])[C@]%15(C)[C@@]6(CC4)C)=O
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Immunology & Inflammation > COX
Neuronal Signaling > COX