COX

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  1. COX inhibitor

    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
  2. COX-2 inhibitor

    Asaraldehyde is a selective COX-2 inhibitor.
  3. COX-2 inhibitor

    Celecoxib is a sulfa non-steroidal anti-inflammatory drug (NSAID) and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis.

  4. COX inhibitor

    Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used as a nonsteroidal anti-inflammatory drug (NSAID) to relieve pain and reduce swelling in flammation.
  5. COX inhibitor

    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM).
  6. COX-1 inhibitor

    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
  7. COX-1 inhibitor

    Ibuprofen Lysine(Motrin) is a non-steroidal anti-inflammatory drug.
  8. COX inhibitor

    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
  9. COX inhibitor

    Naproxen sodium is a non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.
  10. COX inhibitor

    Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent.
  11. COX inhibitor

    Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor.
  12. COX inhibitor

    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).
  13. COX inhibitor

    Sulindac is a non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis, used in the treatment of acute or chronic inflammatory conditions
  14. COX-2 inhibitor

    Iguratimod(T 614) is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity. Iguratimod(T 614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.
  15. COX inhibitor

    Pranoprofen is a non-steroidal anti-inflammatory drug used in ophthalmology
  16. COX inhibitor

    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.
  17. COX inhibitor

    Acemetacin is a glycolic acid ester of indometacin. It is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects.
  18. COX-2 inhibitor

    Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM. It is one of the class of non-steroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of migraine.
  19. COX-2 inhibitor

    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.
  20. COX inhibitor

    Lornoxicam is a non-steroidal COX-1/COX-2 inhibitor. It is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties.
  21. COX/LOX inhibitor

    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.
  22. Hsp90/SRC/COX-2 Inhibitor

    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2
  23. COX-1/COX-2 inhibitor

    Aspirin is a non-selective and irreversible inhibitor of COX-1 and COX-2 with IC50s of 5 and 210 μg/mL.
  24. COX inhibitor/histamine H1 receptor agonist

    Fexofenadine HCl is an antihistamine that inhibits Cox-1, Cox-2, and is a histamine H1 receptor agonist
  25. Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
  26. COX-2 inhibitor

    Rofecoxib (Vioxx) is a COX-2 inhibitor with IC50 of 18 nM.
  27. ATB-337 is a hybrid molecule of an H2S donor and the NSAID diclofenac
  28. COX-1 inhibitor

    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1
  29. Jaceosidin is a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells.
  30. COX-1 inhibitor

    Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany.
  31. COX inhibitor

    (S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor.
  32. COX inhibitor

    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM.
  33. COX/5-LOX inhibitor

    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile
  34. COX-1 inhibitor

    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain.
  35. COX-1 and COX-2 inhibitor

    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
  36. COX-2 inhibitor?€?

    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
  37. COX-2 inhibitor

    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor
  38. COX-2 Inhibitor

    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID.
  39. COX inhibitor

    Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.
  40. COX-1 inhibitor

    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively.
  41. COX-2 inhibitor

    Valdecoxib, also known as SC-65872, is a non-steroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is a selective cyclooxygenase-2 inhibitor.
  42. COX-2 inhibitor

    Parecoxib is a potent and selective COX-2 inhibitor.
  43. COX-2 inhibitor

    Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.
  44. COX-2 inhibitor

    ATB-346 exhibits anti-inflammatory properties similar to naproxen, but with substantially reduced gastrointestinal toxicity.
  45. COX-1 Inhibitor

    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects
  46. COX inhibitor

    Xanthohumol, a prenylated chalcone from hop, inhibits COX-1 and COX-2 activity and shows chemopreventive effects.
  47. Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity.
  48. COX inhibitor

    Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity.
  49. COX inhibitor

    Amfenac Sodium monohydrate is a non-steroidal analgesic anti-inflammatory drug with acetic acid moiety. The IC50 values for COX1 and COX2 is 250 nM and 150 nM, respectively.
  50. COX inhibitor

    Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

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