Click Chemistry

ARS-1323-Alkyne is a novel KRASG12C occupancy probe.

JQ1-TCO (JQ1-trans-cyclooctene) is a derivative of JQ1, a BET inhibitor, modified for click chemistry applications. It serves as a molecular probe for in vitro and in vivo studies.

CPTH2-Alkyne is a selective inhibitor of N-acetyltransferase 10 (NAT10), which plays a crucial role in cellular processes. This compound exhibits distinctive localization, accumulating in nucleoli and associating with the nuclear periphery and cytoplasm. CPTH2-Alkyne is utilized in research focused on nuclear architecture and has potential applications in the study of laminopathies, aiding the understanding of cellular structural dynamics.

Cyanine5 alkyne is a fluorescent dye that functions as an OXPHOS inhibitor, targeting mitochondrial respiration. This compound is primarily utilized in click chemistry applications, allowing for the labeling of azide-containing proteins and analysis of post-translational modifications, including glycosylation. Additionally, Cyanine5 alkyne has demonstrated potential to inhibit the growth of cancer stem cells, making it a valuable tool in cancer research and cellular biology studies.

TcO-ABX474 is a potent inhibitor of prostate-specific membrane antigen (PSMA), exhibiting a Kd value of 6.1 nM. It effectively inhibits the growth and metastasis of prostate cancer cells, making it a valuable tool for research in prostate cancer biology. This compound is suitable for studies investigating PSMA-mediated pathways and the development of targeted therapies for prostate cancer.

H-151 Alkyne is a selective inhibitor of STING (Stimulator of Interferon Genes). This compound demonstrates potential for modulating immune responses, making it valuable in the study of autoimmune diseases such as systemic lupus erythematosus and scleroderma, as well as autoinflammatory conditions. Its ability to interfere with STING pathways allows researchers to explore therapeutic strategies targeting these diseases.

6-Alkyne-F-araNAD is an irreversible inhibitor of CD38, a critical enzyme involved in the regulation of cyclic ADP-ribose and NAD metabolism. This compound enhances the efficacy of fluorescent probes, such as SR101-F-araNMN, allowing for improved visualization of intracellular CD38 localization. It serves as a valuable tool in studies related to immune signaling and cellular response mechanisms.

BCN512 is an inhibitor of Secreted Frizzled-Related Protein 1 (SFRP1). This compound plays a significant role in attenuating tissue fibrosis and is valuable for studying the mechanisms underlying inflammatory diseases. BCN512 provides a useful tool for researchers investigating therapeutic strategies targeting fibrotic pathways.

(Rac)-Ibrutinib alkyne is a potent Bruton's tyrosine kinase (Btk) inhibitor with an IC50 of 0.72 nM. This compound effectively disrupts B-cell receptor signaling, demonstrated by an IC50 of 9 nM for inhibiting calcium flux in Ramos cells. (Rac)-Ibrutinib alkyne is suitable for investigating various Btk-related pathologies, including rheumatoid arthritis and other immune disorders.