COX-1/2-IN-4

Catalog No.: A64433
COX Inhibitor
COX-1/2-IN-4 is a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 0.239 μM and 0.191 μM, respectively. This compound demonstrates moderate anticancer activity against COLO205 and B16F1 cancer cell lines, with IC50 values of 30.79 μM and 74.15 μM. It serves as a valuable tool for research into the roles of COX enzymes in inflammation and cancer.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionCOX-1/2-IN-4 is a dual inhibitor of cyclooxygenase enzymes COX-1 and COX-2, exhibiting IC50 values of 0.239 μM and 0.191 μM, respectively. This compound demonstrates moderate anticancer activity against COLO205 and B16F1 cancer cell lines, with IC50 values of 30.79 μM and 74.15 μM. It serves as a valuable tool for research into the roles of COX enzymes in inflammation and cancer.
Product Information
Catalog NumA64433
FormulaC22H24N2O2S
Molecular Weight380.50
CAS Number2967296-91-7
SMILESCC(C)(C)C(C=C1)=CC=C1NC(C(S2)=C(N=C2C3=CC=CC(OC)=C3)C)=O
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